P01033: Metalloproteinase inhibitor 1

General Information

Protein names	- Metalloproteinase inhibitor 1 - Erythroid-potentiating activity - EPA - Fibroblast collagenase inhibitor - Collagenase inhibitor - Tissue inhibitor of metalloproteinases 1 - TIMP-1
Gene names	TIMP1
Organism	Homo sapiens
Protease Family
Protease ID	I35.001
Chromosome location
UniProt ID	P01033

7 N-termini

7 C-termini

5 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAPFEPLASG ILLLLWLIAP SRACTCVPPH PQTAFCNSDL VIRAKFVGTP EVNQTTLYQR
        70         80         90        100        110        120
YEIKMTKMYK GFQALGDAAD IRFVYTPAME SVCGYFHRSH NRSEEFLIAG KLQDGLLHIT
       130        140        150        160        170        180
TCSFVAPWNS LSLAQRRGFT KTYTVGCEEC TVFPCLSIPC KLQSGTHCLW TDQLLQGSEK
       190        200
GFQSRHLACL PREPGLCTWQ SLRSQIA

Isoforms

Sequence View

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Methodology:

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Evidence Names:

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Lab:

Protein Neighborhood

Domains & Features

7 N-termini - 7 C-termini - 5 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P01033-24-unknown	CTCVPP...	24	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P01033-36-unknown	CNSDLV...	36	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8370
P01033-47-unknown	VGTPEV...	47	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8371
P01033-65-unknown	MTKMYK...	65	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000366216
P01033-93-unknown	CGYFHR...	93	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8639
P01033-125-unknown	VAPWNS...	125	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8372
P01033-129-unknown	NSLSLA...	129	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8373

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...PQTAFC	35	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8370
...IRAKFV	46	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8371
...ADIRFV	83	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000405380
...AMESVC	92	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8639
...TTCSFV	124	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8372
...FVAPWN	128	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8373
...RSQIA	207	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CMA1_HUMAN	35	TAFC.\|.CNSD	inferred from experiment	unknown	MEROPS	Fang KC	Frank BT et al.:Mast cell tissue inhibitor of m... (S01.140)	11160345,
CMA1_HUMAN	46	AKFV.\|.VGTP	inferred from experiment	unknown	MEROPS	Fang KC	Frank BT et al.:Mast cell tissue inhibitor of m... (S01.140)	11160345,
ELNE_HUMAN	92	ESVC.\|.CGYF	inferred from experiment	unknown	MEROPS	Brew K	Nagase H et al.:Involvement of a region near va... (S01.131)	9224642,
CMA1_HUMAN	124	CSFV.\|.VAPW	inferred from experiment	unknown	MEROPS	Fang KC	Frank BT et al.:Mast cell tissue inhibitor of m... (S01.140)	11160345,
CMA1_HUMAN	128	APWN.\|.NSLS	inferred from experiment	unknown	MEROPS	Fang KC	Frank BT et al.:Mast cell tissue inhibitor of m... (S01.140)	11160345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)