P02511: Alpha-crystallin B chain

General Information

Protein names	- Alpha-crystallin B chain - Alpha(B)-crystallin - Heat shock protein beta-5 - HspB5 - Renal carcinoma antigen NY-REN-27 - Rosenthal fiber component
Gene names	CRYAB
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P02511

31 N-termini

34 C-termini

30 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MDIAIHHPWI RRPFFPFHSP SRLFDQFFGE HLLESDLFPT STSLSPFYLR PPSFLRAPSW
        70         80         90        100        110        120
FDTGLSEMRL EKDRFSVNLD VKHFSPEELK VKVLGDVIEV HGKHEERQDE HGFISREFHR
       130        140        150        160        170
KYRIPADVDP LTITSSLSSD GVLTVNGPRK QVSGPERTIP ITREEKPAVT AAPKK

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

31 N-termini - 34 C-termini - 30 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Evidence name
P02511-1-Acetylation	MDIAIH...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P02511-2-unknown	DIAIHH...	2		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC25247
P02511-2-unknown	DIAIHH...	2		inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P02511-3-unknown	IAIHHP...	3		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC25248
P02511-5-unknown	IHHPWI...	5		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC25249
P02511-17-unknown	FHSPSR...	17		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC25250
P02511-23-unknown	LFDQFF...	23		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC25251
P02511-26-unknown	QFFGEH...	26		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC25252
P02511-31-unknown	HLLESD...	31		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC25253
P02511-33-unknown	LESDLF...	33		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC25254
P02511-36-unknown	DLFPTS...	36		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC25255
P02511-41-unknown	STSLSP...	41		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC25256
P02511-43-unknown	SLSPFY...	43		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC25257
P02511-48-unknown	YLRPPS...	48		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC25258
P02511-49-unknown	LRPPSF...	49		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC25259
P02511-55-unknown	LRAPSW...	55		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC25260
P02511-61-unknown	FDTGLS...	61		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC25261
P02511-68-unknown	EMRLEK...	67		inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000435046
P02511-68-unknown	EMRLEK...	67		inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000435411
P02511-68-unknown	EMRLEK...	67		inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000435960
P02511-68-unknown	EMRLEK...	67		inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000434793
P02511-68-unknown	EMRLEK...	67		inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000460304
P02511-68-unknown	EMRLEK...	67		inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000461595
P02511-68-unknown	EMRLEK...	67		inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000461173
P02511-68-unknown	EMRLEK...	67		inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000460404
P02511-68-unknown	EMRLEK...	67		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC25262
P02511-70-unknown	LEKDRF...	70		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC25263
P02511-79-unknown	LDVKHF...	79		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC25264
P02511-89-unknown	LKVKVL...	89		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC25265
P02511-100-unknown	VHGKHE...	100		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC25266
P02511-101-unknown	HGKHEE...	101		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC25267
P02511-103-unknown	KHEERQ...	103		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC25268
P02511-113-unknown	FISREF...	113		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC25269
P02511-122-unknown	YRIPAD...	122		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC25270
P02511-123-unknown	RIPADV...	123		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC25271
P02511-133-unknown	ITSSLS...	133		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC25272
P02511-137-unknown	LSSDGV...	137		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC25273
P02511-151-unknown	QVSGPE...	151		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC25274
P02511-161-unknown	ITREEK...	161		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC25275
P02511-170-unknown	TAAPKK...	170		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC25276

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...RPFFPF	16	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC25250
...HSPSRL	22	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC25251
...SRLFDQ	25	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC25252
...QFFGEH	30	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC25253
...FGEHLL	32	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC25254
...HLLESD	35	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC25255
...DLFPTS	40	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC25256
...FPTSTS	42	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC25257
...SLSPFY	47	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC25258
...LSPFYL	48	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC25259
...RPPSFL	54	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC25260
...RAPSWF	60	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC25261
...TGLSEM	67	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC25262
...GLSEMR	68	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000435931
...GLSEMR	68	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000459282
...LSEMRL	69	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC25263
...DRFSVN	77	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000432182
...DRFSVN	77	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000460515
...RFSVNL	78	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC25264
...FSPEEL	88	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC25265
...GDVIEV	99	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC25266
...DVIEVH	100	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC25267
...IEVHGK	102	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC25268
...QDEHGF	112	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC25269
...EFHRKY	121	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC25270
...FHRKYR	122	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC25271
...PADVDP	129	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000431754
...PADVDP	129	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000460878
...VDPLTI	132	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC25272
...TITSSL	136	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC25273
...NGPRKQ	150	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC25274
...ERTIPI	160	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC25275
...EKPAVT	169	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC25276
...VTAAPK	173	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000434793
...VTAAPK	173	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000460404
...TAAPKK	174	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000436089
...TAAPKK	174	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000460690
...AAPKK	175	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...AAPKK	175		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...AAPKK	175		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MMP9_HUMAN	1	.\|.DIAI	inferred from experiment	unknown	MEROPS	Opdenakker G	Starckx S et al.:A novel rationale for inhibitio... (M10.004)	12965253,
MMP9_HUMAN	2	.\|.IAIH	inferred from experiment	unknown	MEROPS	Opdenakker G	Starckx S et al.:A novel rationale for inhibitio... (M10.004)	12965253,
MMP9_HUMAN	4	DIAI.\|.IHHP	inferred from experiment	unknown	MEROPS	Opdenakker G	Starckx S et al.:A novel rationale for inhibitio... (M10.004)	12965253,
MMP9_HUMAN	16	FFPF.\|.FHSP	inferred from experiment	unknown	MEROPS	Opdenakker G	Starckx S et al.:A novel rationale for inhibitio... (M10.004)	12965253,
MMP9_HUMAN	22	PSRL.\|.LFDQ	inferred from experiment	unknown	MEROPS	Opdenakker G	Starckx S et al.:A novel rationale for inhibitio... (M10.004)	12965253,
MMP9_HUMAN	25	LFDQ.\|.QFFG	inferred from experiment	unknown	MEROPS	Opdenakker G	Starckx S et al.:A novel rationale for inhibitio... (M10.004)	12965253,
MMP9_HUMAN	30	FGEH.\|.HLLE	inferred from experiment	unknown	MEROPS	Opdenakker G	Starckx S et al.:A novel rationale for inhibitio... (M10.004)	12965253,
MMP9_HUMAN	32	EHLL.\|.LESD	inferred from experiment	unknown	MEROPS	Opdenakker G	Starckx S et al.:A novel rationale for inhibitio... (M10.004)	12965253,
MMP9_HUMAN	35	LESD.\|.DLFP	inferred from experiment	unknown	MEROPS	Opdenakker G	Starckx S et al.:A novel rationale for inhibitio... (M10.004)	12965253,
MMP9_HUMAN	40	FPTS.\|.STSL	inferred from experiment	unknown	MEROPS	Opdenakker G	Starckx S et al.:A novel rationale for inhibitio... (M10.004)	12965253,
MMP9_HUMAN	42	TSTS.\|.SLSP	inferred from experiment	unknown	MEROPS	Opdenakker G	Starckx S et al.:A novel rationale for inhibitio... (M10.004)	12965253,
MMP9_HUMAN	47	SPFY.\|.YLRP	inferred from experiment	unknown	MEROPS	Opdenakker G	Starckx S et al.:A novel rationale for inhibitio... (M10.004)	12965253,
MMP9_HUMAN	48	PFYL.\|.LRPP	inferred from experiment	unknown	MEROPS	Opdenakker G	Starckx S et al.:A novel rationale for inhibitio... (M10.004)	12965253,
MMP9_HUMAN	54	PSFL.\|.LRAP	inferred from experiment	unknown	MEROPS	Opdenakker G	Starckx S et al.:A novel rationale for inhibitio... (M10.004)	12965253,
MMP9_HUMAN	60	PSWF.\|.FDTG	inferred from experiment	unknown	MEROPS	Opdenakker G	Starckx S et al.:A novel rationale for inhibitio... (M10.004)	12965253,
MMP9_HUMAN	67	LSEM.\|.MRLE	inferred from experiment	unknown	MEROPS	Opdenakker G	Starckx S et al.:A novel rationale for inhibitio... (M10.004)	12965253,
MMP9_HUMAN	69	EMRL.\|.LEKD	inferred from experiment	unknown	MEROPS	Opdenakker G	Starckx S et al.:A novel rationale for inhibitio... (M10.004)	12965253,
MMP9_HUMAN	78	SVNL.\|.LDVK	inferred from experiment	unknown	MEROPS	Opdenakker G	Starckx S et al.:A novel rationale for inhibitio... (M10.004)	12965253,
MMP9_HUMAN	88	PEEL.\|.LKVK	inferred from experiment	unknown	MEROPS	Opdenakker G	Starckx S et al.:A novel rationale for inhibitio... (M10.004)	12965253,
MMP9_HUMAN	99	VIEV.\|.VHGK	inferred from experiment	unknown	MEROPS	Opdenakker G	Starckx S et al.:A novel rationale for inhibitio... (M10.004)	12965253,
MMP9_HUMAN	100	IEVH.\|.HGKH	inferred from experiment	unknown	MEROPS	Opdenakker G	Starckx S et al.:A novel rationale for inhibitio... (M10.004)	12965253,
MMP9_HUMAN	102	VHGK.\|.KHEE	inferred from experiment	unknown	MEROPS	Opdenakker G	Starckx S et al.:A novel rationale for inhibitio... (M10.004)	12965253,
MMP9_HUMAN	112	EHGF.\|.FISR	inferred from experiment	unknown	MEROPS	Opdenakker G	Starckx S et al.:A novel rationale for inhibitio... (M10.004)	12965253,
MMP9_HUMAN	121	HRKY.\|.YRIP	inferred from experiment	unknown	MEROPS	Opdenakker G	Starckx S et al.:A novel rationale for inhibitio... (M10.004)	12965253,
MMP9_HUMAN	122	RKYR.\|.RIPA	inferred from experiment	unknown	MEROPS	Opdenakker G	Starckx S et al.:A novel rationale for inhibitio... (M10.004)	12965253,
MMP9_HUMAN	132	PLTI.\|.ITSS	inferred from experiment	unknown	MEROPS	Opdenakker G	Starckx S et al.:A novel rationale for inhibitio... (M10.004)	12965253,
MMP9_HUMAN	136	TSSL.\|.LSSD	inferred from experiment	unknown	MEROPS	Opdenakker G	Starckx S et al.:A novel rationale for inhibitio... (M10.004)	12965253,
MMP9_HUMAN	150	PRKQ.\|.QVSG	inferred from experiment	unknown	MEROPS	Opdenakker G	Starckx S et al.:A novel rationale for inhibitio... (M10.004)	12965253,
MMP9_HUMAN	160	TIPI.\|.ITRE	inferred from experiment	unknown	MEROPS	Opdenakker G	Starckx S et al.:A novel rationale for inhibitio... (M10.004)	12965253,
MMP9_HUMAN	169	PAVT.\|.TAAP	inferred from experiment	unknown	MEROPS	Opdenakker G	Starckx S et al.:A novel rationale for inhibitio... (M10.004)	12965253,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)