P04183: Thymidine kinase, cytosolic

General Information

Protein names	- Thymidine kinase, cytosolic - 2.7.1.21
Gene names	TK1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P04183

2 N-termini

4 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSCINLPTVL PGSPSKTRGQ IQVILGPMFS GKSTELMRRV RRFQIAQYKC LVIKYAKDTR
        70         80         90        100        110        120
YSSSFCTHDR NTMEALPACL LRDVAQEALG VAVIGIDEGQ FFPDIVEFCE AMANAGKTVI
       130        140        150        160        170        180
VAALDGTFQR KPFGAILNLV PLAESVVKLT AVCMECFREA AYTKRLGTEK EVEVIGGADK
       190        200        210        220        230
YHSVCRLCYF KKASGQPAGP DNKENCPVPG KPGEAVAARK LFAPQQILQC SPAN

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

2 N-termini - 4 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P04183-2-unknown	MSCINL...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P04183-2-Acetylation	SCINLP...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P04183-2-Acetylation	SCINLP...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P04183-2-Acetylation	SCINLP...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
P04183-2-Acetylation	SCINLP...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...IGGADK	179	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000468278
...QQILQC	229	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13913
...CSPAN	234		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...CSPAN	234	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...CSPAN	234		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...CSPAN	234		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAM_HUMAN	229	ILQC.\|.CSPA	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)