P05120: Plasminogen activator inhibitor 2

General Information

Protein names	- Plasminogen activator inhibitor 2 - PAI-2 - Monocyte Arg-serpin - Placental plasminogen activator inhibitor - Serpin B2 - Urokinase inhibitor
Gene names	SERPINB2
Organism	Homo sapiens
Protease Family
Protease ID	I04.007
Chromosome location
UniProt ID	P05120

3 N-termini

6 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MEDLCVANTL FALNLFKHLA KASPTQNLFL SPWSISSTMA MVYMGSRGST EDQMAKVLQF
        70         80         90        100        110        120
NEVGANAVTP MTPENFTSCG FMQQIQKGSY PDAILQAQAA DKIHSSFRSL SSAINASTGN
       130        140        150        160        170        180
YLLESVNKLF GEKSASFREE YIRLCQKYYS SEPQAVDFLE CAEEARKKIN SWVKTQTKGK
       190        200        210        220        230        240
IPNLLPEGSV DGDTRMVLVN AVYFKGKWKT PFEKKLNGLY PFRVNSAQRT PVQMMYLREK
       250        260        270        280        290        300
LNIGYIEDLK AQILELPYAG DVSMFLLLPD EIADVSTGLE LLESEITYDK LNKWTSKDKM
       310        320        330        340        350        360
AEDEVEVYIP QFKLEEHYEL RSILRSMGME DAFNKGRANF SGMSERNDLF LSEVFHQAMV
       370        380        390        400        410
DVNEEGTEAA AGTGGVMTGR TGHGGPQFVA DHPFLFLIMH KITNCILFFG RFSSP

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

3 N-termini - 6 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P05120-1-unknown	MEDLCV...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P05120-85-unknown	IQKGSY...	85	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17115
P05120-97-unknown	AQAADK...	97	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17116

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...GFMQQI	84	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17115
...DAILQA	96	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17116
...SLSSAI	113	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000385397
...KLFGEK	132	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000397096
...DFLECA	161	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000402386
...RFSSP	415	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1A_HUMAN	84	MQQI.\|.IQKG	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	96	ILQA.\|.AQAA	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)