P05549: Transcription factor AP-2-alpha

General Information

Protein names	- Transcription factor AP-2-alpha - AP2-alpha - AP-2 transcription factor - Activating enhancer-binding protein 2-alpha - Activator protein 2 - AP-2
Gene names	TFAP2A
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P05549

2 N-termini

2 C-termini

3 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Transcription factor AP-2-alpha - Isoform 4 of Transcription factor AP-2-alpha - Isoform 5 of Transcription factor AP-2-alpha

Sequence View

        10         20         30         40         50         60
MLWKLTDNIK YEDCEDRHDG TSNGTARLPQ LGTVGQSPYT SAPPLSHTPN ADFQPPYFPP
        70         80         90        100        110        120
PYQPIYPQSQ DPYSHVNDPY SLNPLHAQPQ PQHPGWPGQR QSQESGLLHT HRGLPHQLSG
       130        140        150        160        170        180
LDPRRDYRRH EDLLHGPHAL SSGLGDLSIH SLPHAIEEVP HVEDPGINIP DQTVIKKGPV
       190        200        210        220        230        240
SLSKSNSNAV SAIPINKDNL FGGVVNPNEV FCSVPGRLSL LSSTSKYKVT VAEVQRRLSP
       250        260        270        280        290        300
PECLNASLLG GVLRRAKSKN GGRSLREKLD KIGLNLPAGR RKAANVTLLT SLVEGEAVHL
       310        320        330        340        350        360
ARDFGYVCET EFPAKAVAEF LNRQHSDPNE QVTRKNMLLA TKQICKEFTD LLAQDRSPLG
       370        380        390        400        410        420
NSRPNPILEP GIQSCLTHFN LISHGFGSPA VCAAVTALQN YLTEALKAMD KMYLSNNPNS
       430
HTDNNAKSSD KEEKHRK         10         20         30         40         50         60
MLWKLTDNIK YEDCEDRHDG TSNGTARLPQ LGTVGQSPYT SAPPLSHTPN ADFQPPYFPP
        70         80         90        100        110        120
PYQPIYPQSQ DPYSHVNDPY SLNPLHAQPQ PQHPGWPGQR QSQESGLLHT HRGLPHQLSG
       130        140        150        160        170        180
LDPRRDYRRH EDLLHGPHAL SSGLGDLSIH SLPHAIEEVP HVEDPGINIP DQTVIKKGPV
       190        200        210        220        230        240
SLSKSNSNAV SAIPINKDNL FGGVVNPNEV FCSVPGRLSL LSSTSKYKVT VAEVQRRLSP
       250        260        270        280        290        300
PECLNASLLG GVLRRAKSKN GGRSLREKLD KIGLNLPAGR RKAANVTLLT SLVEGEAVHL
       310        320        330        340        350        360
ARDFGYVCET EFPAKAVAEF LNRQHSDPNE QVTRKNMLLA TKQICKEFTD LLAQDRSPLG
       370        380        390        400        410        420
NSRPNPILEP GIQSCLTHFN LISHGFGSPA VCAAVTALQN YLTEALKAMD KMYLSNNPNS
       430
HTDNNAKSSD KEEKHRK         10         20         30         40         50         60
MLWKLTDNIK YEDCEDRHDG TSNGTARLPQ LGTVGQSPYT SAPPLSHTPN ADFQPPYFPP
        70         80         90        100        110        120
PYQPIYPQSQ DPYSHVNDPY SLNPLHAQPQ PQHPGWPGQR QSQESGLLHT HRGLPHQLSG
       130        140        150        160        170        180
LDPRRDYRRH EDLLHGPHAL SSGLGDLSIH SLPHAIEEVP HVEDPGINIP DQTVIKKGPV
       190        200        210        220        230        240
SLSKSNSNAV SAIPINKDNL FGGVVNPNEV FCSVPGRLSL LSSTSKYKVT VAEVQRRLSP
       250        260        270        280        290        300
PECLNASLLG GVLRRAKSKN GGRSLREKLD KIGLNLPAGR RKAANVTLLT SLVEGEAVHL
       310        320        330        340        350        360
ARDFGYVCET EFPAKAVAEF LNRQHSDPNE QVTRKNMLLA TKQICKEFTD LLAQDRSPLG
       370        380        390        400        410        420
NSRPNPILEP GIQSCLTHFN LISHGFGSPA VCAAVTALQN YLTEALKAMD KMYLSNNPNS
       430
HTDNNAKSSD KEEKHRK

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

2 N-termini - 2 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P05549-1-unknown	MLWKLT...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P05549-1-unknown	MLWKLT...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt67141
P05549-20-unknown	GTSNGT...	20	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1566
P05549-20-unknown	GTSNGT...	20	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1123
P05549-20-unknown	GTSNGT...	20	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2458
P05549-20-unknown	GTSNGT...	20	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt136830
P05549-20-unknown	GTSNGT...	20	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt195199
P05549-20-unknown	GTSNGT...	20	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt195198

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...EDRHDG	19	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1566
...EDRHDG	19	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1123
...EDRHDG	19	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2458
...EKHRK	437	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...EKHRK	437	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt62758
...EKHRK	437	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt62760

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP3_HUMAN	19	RHDG.\|.GTSN	inferred from experiment	unknown	MEROPS	Bar-Eli M	Nyormoi O et al.:Transcription factor AP-2alpha ... (C14.001)	11438643,
CASP1_HUMAN	19	RHDG.\|.GTSN	inferred from experiment	unknown	MEROPS	Bar-Eli M	Nyormoi O et al.:Transcription factor AP-2alpha ... (C14.001)	11438643,
CASP6_HUMAN	19	RHDG.\|.GTSN	inferred from experiment	unknown	MEROPS	Bar-Eli M	Nyormoi O et al.:Transcription factor AP-2alpha ... (C14.001)	11438643,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)