P05771: Protein kinase C beta type

General Information

Protein names	- Protein kinase C beta type - PKC-B - PKC-beta - 2.7.11.13 {ECO:0000269\|PubMed:20228790, ECO:0000269\|PubMed:25982116}
Gene names	PRKCB
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P05771

5 N-termini

5 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MADPAAGPPP SEGEESTVRF ARKGALRQKN VHEVKNHKFT ARFFKQPTFC SHCTDFIWGF
        70         80         90        100        110        120
GKQGFQCQVC CFVVHKRCHE FVTFSCPGAD KGPASDDPRS KHKFKIHTYS SPTFCDHCGS
       130        140        150        160        170        180
LLYGLIHQGM KCDTCMMNVH KRCVMNVPSL CGTDHTERRG RIYIQAHIDR DVLIVLVRDA
       190        200        210        220        230        240
KNLVPMDPNG LSDPYVKLKL IPDPKSESKQ KTKTIKCSLN PEWNETFRFQ LKESDKDRRL
       250        260        270        280        290        300
SVEIWDWDLT SRNDFMGSLS FGISELQKAS VDGWFKLLSQ EEGEYFNVPV PPEGSEANEE
       310        320        330        340        350        360
LRQKFERAKI SQGTKVPEEK TTNTVSKFDN NGNRDRMKLT DFNFLMVLGK GSFGKVMLSE
       370        380        390        400        410        420
RKGTDELYAV KILKKDVVIQ DDDVECTMVE KRVLALPGKP PFLTQLHSCF QTMDRLYFVM
       430        440        450        460        470        480
EYVNGGDLMY HIQQVGRFKE PHAVFYAAEI AIGLFFLQSK GIIYRDLKLD NVMLDSEGHI
       490        500        510        520        530        540
KIADFGMCKE NIWDGVTTKT FCGTPDYIAP EIIAYQPYGK SVDWWAFGVL LYEMLAGQAP
       550        560        570        580        590        600
FEGEDEDELF QSIMEHNVAY PKSMSKEAVA ICKGLMTKHP GKRLGCGPEG ERDIKEHAFF
       610        620        630        640        650        660
RYIDWEKLER KEIQPPYKPK ARDKRDTSNF DKEFTRQPVE LTPTDKLFIM NLDQNEFAGF
       670
SYTNPEFVIN V

Isoforms

- Isoform Beta-II of Protein kinase C beta type

Sequence View

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Protein Neighborhood

Domains & Features

5 N-termini - 5 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P05771-2-unknown	MADPAA...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P05771-1-unknown	MADPAA...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt79207
P05771-2-Acetylation	ADPAAG...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P05771-2-Acetylation	ADPAAG...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P05771-2-Acetylation	ADPAAG...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110517
P05771-186-unknown	MDPNGL...	186		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000459227
P05771-186-unknown	MDPNGL...	186		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt197939
P05771-382-unknown	DDVECT...	382		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11049
P05771-382-unknown	DDVECT...	382		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt151665

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...CTDFIW	57	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000454428
...CTDFIW	57	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt153927
...ELRQKF	304	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000459227
...VVIQDD	381	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11049
...VVIQDD	381	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135068
...HIKIAD	483	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000457980
...FVINV	671	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	381	IQDD.\|.DDVE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)