P06241: Tyrosine-protein kinase Fyn

General Information

Protein names	- Tyrosine-protein kinase Fyn - 2.7.10.2 - Proto-oncogene Syn - Proto-oncogene c-Fyn - Src-like kinase - SLK - p59-Fyn
Gene names	FYN
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P06241

4 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Tyrosine-protein kinase Fyn - Isoform 3 of Tyrosine-protein kinase Fyn

Sequence View

        10         20         30         40         50         60
MGCVQCKDKE ATKLTEERDG SLNQSSGYRY GTDPTPQHYP SFGVTSIPNY NNFHAAGGQG
        70         80         90        100        110        120
LTVFGGVNSS SHTGTLRTRG GTGVTLFVAL YDYEARTEDD LSFHKGEKFQ ILNSSEGDWW
       130        140        150        160        170        180
EARSLTTGET GYIPSNYVAP VDSIQAEEWY FGKLGRKDAE RQLLSFGNPR GTFLIRESET
       190        200        210        220        230        240
TKGAYSLSIR DWDDMKGDHV KHYKIRKLDN GGYYITTRAQ FETLQQLVQH YSERAAGLCC
       250        260        270        280        290        300
RLVVPCHKGM PRLTDLSVKT KDVWEIPRES LQLIKRLGNG QFGEVWMGTW NGNTKVAIKT
       310        320        330        340        350        360
LKPGTMSPES FLEEAQIMKK LKHDKLVQLY AVVSEEPIYI VTEYMNKGSL LDFLKDGEGR
       370        380        390        400        410        420
ALKLPNLVDM AAQVAAGMAY IERMNYIHRD LRSANILVGN GLICKIADFG LARLIEDNEY
       430        440        450        460        470        480
TARQGAKFPI KWTAPEAALY GRFTIKSDVW SFGILLTELV TKGRVPYPGM NNREVLEQVE
       490        500        510        520        530
RGYRMPCPQD CPISLHELMI HCWKKDPEER PTFEYLQSFL EDYFTATEPQ YQPGENL         10         20         30         40         50         60
MGCVQCKDKE ATKLTEERDG SLNQSSGYRY GTDPTPQHYP SFGVTSIPNY NNFHAAGGQG
        70         80         90        100        110        120
LTVFGGVNSS SHTGTLRTRG GTGVTLFVAL YDYEARTEDD LSFHKGEKFQ ILNSSEGDWW
       130        140        150        160        170        180
EARSLTTGET GYIPSNYVAP VDSIQAEEWY FGKLGRKDAE RQLLSFGNPR GTFLIRESET
       190        200        210        220        230        240
TKGAYSLSIR DWDDMKGDHV KHYKIRKLDN GGYYITTRAQ FETLQQLVQH YSERAAGLCC
       250        260        270        280        290        300
RLVVPCHKGM PRLTDLSVKT KDVWEIPRES LQLIKRLGNG QFGEVWMGTW NGNTKVAIKT
       310        320        330        340        350        360
LKPGTMSPES FLEEAQIMKK LKHDKLVQLY AVVSEEPIYI VTEYMNKGSL LDFLKDGEGR
       370        380        390        400        410        420
ALKLPNLVDM AAQVAAGMAY IERMNYIHRD LRSANILVGN GLICKIADFG LARLIEDNEY
       430        440        450        460        470        480
TARQGAKFPI KWTAPEAALY GRFTIKSDVW SFGILLTELV TKGRVPYPGM NNREVLEQVE
       490        500        510        520        530
RGYRMPCPQD CPISLHELMI HCWKKDPEER PTFEYLQSFL EDYFTATEPQ YQPGENL

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P06241-1-unknown	MGCVQC...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt75612
P06241-1-unknown	MGCVQC...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt75613
P06241-2-unknown	GCVQCK...	2	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P06241-2-unknown	GCVQCK...	2	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110134
P06241-2-unknown	GCVQCK...	2	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110135
P06241-20-unknown	GSLNQS...	20	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1570
P06241-20-unknown	GSLNQS...	20	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt136833
P06241-20-unknown	GSLNQS...	20	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt136834
P06241-20-	GSLNQS...	20		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...TEERDG	19	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1570
...PGENL	537	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...PGENL	537	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt71231
...PGENL	537	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt71230

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP3_HUMAN	19	ERDG.\|.GSLN	inferred from experiment	unknown	MEROPS	Auberger P	Ricci JE et al.:Cleavage and relocation of the ... (C14.003)	10435619,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)