P07093: Glia-derived nexin

General Information

Protein names	- Glia-derived nexin - GDN - Peptidase inhibitor 7 - PI-7 - Protease nexin 1 - PN-1 - Protease nexin I - Serpin E2
Gene names	SERPINE2
Organism	Homo sapiens
Protease Family
Protease ID	I04.021
Chromosome location
UniProt ID	P07093

13 N-termini

11 C-termini

10 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Glia-derived nexin - Isoform 3 of Glia-derived nexin

Sequence View

        10         20         30         40         50         60
MNWHLPLFLL ASVTLPSICS HFNPLSLEEL GSNTGIQVFN QIVKSRPHDN IVISPHGIAS
        70         80         90        100        110        120
VLGMLQLGAD GRTKKQLAMV MRYGVNGVGK ILKKINKAIV SKKNKDIVTV ANAVFVKNAS
       130        140        150        160        170        180
EIEVPFVTRN KDVFQCEVRN VNFEDPASAC DSINAWVKNE TRDMIDNLLS PDLIDGVLTR
       190        200        210        220        230        240
LVLVNAVYFK GLWKSRFQPE NTKKRTFVAA DGKSYQVPML AQLSVFRCGS TSAPNDLWYN
       250        260        270        280        290        300
FIELPYHGES ISMLIALPTE SSTPLSAIIP HISTKTIDSW MSIMVPKRVQ VILPKFTAVA
       310        320        330        340        350        360
QTDLKEPLKV LGITDMFDSS KANFAKITTG SENLHVSHIL QKAKIEVSED GTKASAATTA
       370        380        390
ILIARSSPPW FIVDRPFLFF IRHNPTGAVL FMGQINKP         10         20         30         40         50         60
MNWHLPLFLL ASVTLPSICS HFNPLSLEEL GSNTGIQVFN QIVKSRPHDN IVISPHGIAS
        70         80         90        100        110        120
VLGMLQLGAD GRTKKQLAMV MRYGVNGVGK ILKKINKAIV SKKNKDIVTV ANAVFVKNAS
       130        140        150        160        170        180
EIEVPFVTRN KDVFQCEVRN VNFEDPASAC DSINAWVKNE TRDMIDNLLS PDLIDGVLTR
       190        200        210        220        230        240
LVLVNAVYFK GLWKSRFQPE NTKKRTFVAA DGKSYQVPML AQLSVFRCGS TSAPNDLWYN
       250        260        270        280        290        300
FIELPYHGES ISMLIALPTE SSTPLSAIIP HISTKTIDSW MSIMVPKRVQ VILPKFTAVA
       310        320        330        340        350        360
QTDLKEPLKV LGITDMFDSS KANFAKITTG SENLHVSHIL QKAKIEVSED GTKASAATTA
       370        380        390
ILIARSSPPW FIVDRPFLFF IRHNPTGAVL FMGQINKP

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

13 N-termini - 11 C-termini - 10 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P07093-1-unknown	MNWHLP...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt75858
P07093-1-unknown	MNWHLP...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt100568
P07093-20-unknown	SHFNPL...	20	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P07093-20-unknown	SHFNPL...	20	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt112312
P07093-20-unknown	SHFNPL...	20	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt112311
P07093-20-	SHFNPL...	20		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P07093-58-unknown	IASVLG...	58	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC25635
P07093-58-unknown	IASVLG...	58	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt139721
P07093-58-unknown	IASVLG...	58	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt140610
P07093-59-unknown	ASVLGM...	59	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC25638
P07093-59-unknown	ASVLGM...	59	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt139799
P07093-59-unknown	ASVLGM...	59	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt140698
P07093-64-unknown	MLQLGA...	64	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC25641
P07093-64-unknown	MLQLGA...	64	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt140225
P07093-64-unknown	MLQLGA...	64	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt141022
P07093-106-unknown	DIVTVA...	106	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC25644
P07093-106-unknown	DIVTVA...	106	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt142679
P07093-106-unknown	DIVTVA...	106	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt143349
P07093-108-unknown	VTVANA...	108	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC25647
P07093-108-unknown	VTVANA...	108	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt142808
P07093-108-unknown	VTVANA...	108	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt143464
P07093-255-unknown	IALPTE...	255	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC25650
P07093-255-unknown	IALPTE...	255	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt148635
P07093-255-unknown	IALPTE...	255	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt149038
P07093-300-unknown	AQTDLK...	300	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC25653
P07093-300-unknown	AQTDLK...	300	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt149856
P07093-300-unknown	AQTDLK...	300	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt150150
P07093-313-unknown	ITDMFD...	313	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC25656
P07093-348-unknown	SEDGTK...	348	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC25659
P07093-348-unknown	SEDGTK...	348	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt150884
P07093-348-unknown	SEDGTK...	348	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt151132
P07093-368-unknown	PPWFIV...	368	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC25662
P07093-368-unknown	PPWFIV...	368	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt151343
P07093-368-unknown	PPWFIV...	368	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt151583

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...ISPHGI	57	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC25635
...ISPHGI	57	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt122820
...ISPHGI	57	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt123744
...SPHGIA	58	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC25638
...SPHGIA	58	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt122898
...SPHGIA	58	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt123833
...ASVLGM	63	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC25641
...ASVLGM	63	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt123341
...ASVLGM	63	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt124172
...SKKNKD	105	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC25644
...SKKNKD	105	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt125879
...SKKNKD	105	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126581
...KNKDIV	107	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC25647
...KNKDIV	107	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126014
...KNKDIV	107	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126697
...SISMLI	254	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC25650
...SISMLI	254	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132009
...SISMLI	254	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132422
...KFTAVA	299	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC25653
...KFTAVA	299	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133247
...KFTAVA	299	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133543
...LKVLGI	312	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC25656
...LKVLGI	312	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133572
...LKVLGI	312	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133825
...AKIEVS	347	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC25659
...IARSSP	367	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC25662
...IARSSP	367	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134745
...IARSSP	367	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134989
...QINKP	398	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...QINKP	398	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt71476
...QINKP	398	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt71477

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MMP9_HUMAN	57	PHGI.\|.IASV	inferred from experiment	unknown	MEROPS	Kessler BM	Xu D et al.:Novel MMP-9 substrates in cance... (M10.004)	18596065,
MMP9_HUMAN	58	HGIA.\|.ASVL	inferred from experiment	unknown	MEROPS	Kessler BM	Xu D et al.:Novel MMP-9 substrates in cance... (M10.004)	18596065,
MMP9_HUMAN	63	VLGM.\|.MLQL	inferred from experiment	unknown	MEROPS	Kessler BM	Xu D et al.:Novel MMP-9 substrates in cance... (M10.004)	18596065,
MMP9_HUMAN	105	KNKD.\|.DIVT	inferred from experiment	unknown	MEROPS	Kessler BM	Xu D et al.:Novel MMP-9 substrates in cance... (M10.004)	18596065,
MMP9_HUMAN	107	KDIV.\|.VTVA	inferred from experiment	unknown	MEROPS	Kessler BM	Xu D et al.:Novel MMP-9 substrates in cance... (M10.004)	18596065,
MMP9_HUMAN	254	SMLI.\|.IALP	inferred from experiment	unknown	MEROPS	Kessler BM	Xu D et al.:Novel MMP-9 substrates in cance... (M10.004)	18596065,
MMP9_HUMAN	299	TAVA.\|.AQTD	inferred from experiment	unknown	MEROPS	Kessler BM	Xu D et al.:Novel MMP-9 substrates in cance... (M10.004)	18596065,
MMP9_HUMAN	312	VLGI.\|.ITDM	inferred from experiment	unknown	MEROPS	Kessler BM	Xu D et al.:Novel MMP-9 substrates in cance... (M10.004)	18596065,
MMP9_HUMAN	347	IEVS.\|.SEDG	inferred from experiment	unknown	MEROPS	Kessler BM	Xu D et al.:Novel MMP-9 substrates in cance... (M10.004)	18596065,
MMP9_HUMAN	367	RSSP.\|.PPWF	inferred from experiment	unknown	MEROPS	Kessler BM	Xu D et al.:Novel MMP-9 substrates in cance... (M10.004)	18596065,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)