P07197: Neurofilament medium polypeptide

General Information

Protein names	- Neurofilament medium polypeptide - NF-M - 160 kDa neurofilament protein - Neurofilament 3 - Neurofilament triplet M protein
Gene names	NEFM
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P07197

3 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSYTLDSLGN PSAYRRVTET RSSFSRVSGS PSSGFRSQSW SRGSPSTVSS SYKRSMLAPR
        70         80         90        100        110        120
LAYSSAMLSS AESSLDFSQS SSLLNGGSGP GGDYKLSRSN EKEQLQGLND RFAGYIEKVH
       130        140        150        160        170        180
YLEQQNKEIE AEIQALRQKQ ASHAQLGDAY DQEIRELRAT LEMVNHEKAQ VQLDSDHLEE
       190        200        210        220        230        240
DIHRLKERFE EEARLRDDTE AAIRALRKDI EEASLVKVEL DKKVQSLQDE VAFLRSNHEE
       250        260        270        280        290        300
EVADLLAQIQ ASHITVERKD YLKTDISTAL KEIRSQLESH SDQNMHQAEE WFKCRYAKLT
       310        320        330        340        350        360
EAAEQNKEAI RSAKEEIAEY RRQLQSKSIE LESVRGTKES LERQLSDIEE RHNHDLSSYQ
       370        380        390        400        410        420
DTIQQLENEL RGTKWEMARH LREYQDLLNV KMALDIEIAA YRKLLEGEET RFSTFAGSIT
       430        440        450        460        470        480
GPLYTHRPPI TISSKIQKPK VEAPKLKVQH KFVEEIIEET KVEDEKSEME EALTAITEEL
       490        500        510        520        530        540
AVSMKEEKKE AAEEKEEEPE AEEEEVAAKK SPVKATAPEV KEEEGEKEEE EGQEEEEEED
       550        560        570        580        590        600
EGAKSDQAEE GGSEKEGSSE KEEGEQEEGE TEAEAEGEEA EAKEEKKVEE KSEEVATKEE
       610        620        630        640        650        660
LVADAKVEKP EKAKSPVPKS PVEEKGKSPV PKSPVEEKGK SPVPKSPVEE KGKSPVPKSP
       670        680        690        700        710        720
VEEKGKSPVS KSPVEEKAKS PVPKSPVEEA KSKAEVGKGE QKEEEEKEVK EAPKEEKVEK
       730        740        750        760        770        780
KEEKPKDVPE KKKAESPVKE EAVAEVVTIT KSVKVHLEKE TKEEGKPLQQ EKEKEKAGGE
       790        800        810        820        830        840
GGSEEEGSDK GAKGSRKEDI AVNGEVEGKE EVEQETKEKG SGREEEKGVV TNGLDLSPAD
       850        860        870        880        890        900
EKKGGDKSEE KVVVTKTVEK ITSEGGDGAT KYITKSVTVT QKVEEHEETF EEKLVSTKKV
       910
EKVTSHAIVK EVTQSD

Isoforms

- Isoform 2 of Neurofilament medium polypeptide - Isoform 2 of Neurofilament medium polypeptide

Sequence View

        10         20         30         40         50         60
MSYTLDSLGN PSAYRRVTET RSSFSRVSGS PSSGFRSQSW SRGSPSTVSS SYKRSMLAPR
        70         80         90        100        110        120
LAYSSAMLSS AESSLDFSQS SSLLNGGSGP GGDYKLSRSN EKEQLQGLND RFAGYIEKVH
       130        140        150        160        170        180
YLEQQNKEIE AEIQALRQKQ ASHAQLGDAY DQEIRELRAT LEMVNHEKAQ VQLDSDHLEE
       190        200        210        220        230        240
DIHRLKERFE EEARLRDDTE AAIRALRKDI EEASLVKVEL DKKVQSLQDE VAFLRSNHEE
       250        260        270        280        290        300
EVADLLAQIQ ASHITVERKD YLKTDISTAL KEIRSQLESH SDQNMHQAEE WFKCRYAKLT
       310        320        330        340        350        360
EAAEQNKEAI RSAKEEIAEY RRQLQSKSIE LESVRGTKES LERQLSDIEE RHNHDLSSYQ
       370        380        390        400        410        420
DTIQQLENEL RGTKWEMARH LREYQDLLNV KMALDIEIAA YRKLLEGEET RFSTFAGSIT
       430        440        450        460        470        480
GPLYTHRPPI TISSKIQKPK VEAPKLKVQH KFVEEIIEET KVEDEKSEME EALTAITEEL
       490        500        510        520        530        540
AVSMKEEKKE AAEEKEEEPE AEEEEVAAKK SPVKATAPEV KEEEGEKEEE EGQEEEEEED
       550        560        570        580        590        600
EGAKSDQAEE GGSEKEGSSE KEEGEQEEGE TEAEAEGEEA EAKEEKKVEE KSEEVATKEE
       610        620        630        640        650        660
LVADAKVEKP EKAKSPVPKS PVEEKGKSPV PKSPVEEKGK SPVPKSPVEE KGKSPVPKSP
       670        680        690        700        710        720
VEEKGKSPVS KSPVEEKAKS PVPKSPVEEA KSKAEVGKGE QKEEEEKEVK EAPKEEKVEK
       730        740        750        760        770        780
KEEKPKDVPE KKKAESPVKE EAVAEVVTIT KSVKVHLEKE TKEEGKPLQQ EKEKEKAGGE
       790        800        810        820        830        840
GGSEEEGSDK GAKGSRKEDI AVNGEVEGKE EVEQETKEKG SGREEEKGVV TNGLDLSPAD
       850        860        870        880        890        900
EKKGGDKSEE KVVVTKTVEK ITSEGGDGAT KYITKSVTVT QKVEEHEETF EEKLVSTKKV
       910
EKVTSHAIVK EVTQSD         10         20         30         40         50         60
MSYTLDSLGN PSAYRRVTET RSSFSRVSGS PSSGFRSQSW SRGSPSTVSS SYKRSMLAPR
        70         80         90        100        110        120
LAYSSAMLSS AESSLDFSQS SSLLNGGSGP GGDYKLSRSN EKEQLQGLND RFAGYIEKVH
       130        140        150        160        170        180
YLEQQNKEIE AEIQALRQKQ ASHAQLGDAY DQEIRELRAT LEMVNHEKAQ VQLDSDHLEE
       190        200        210        220        230        240
DIHRLKERFE EEARLRDDTE AAIRALRKDI EEASLVKVEL DKKVQSLQDE VAFLRSNHEE
       250        260        270        280        290        300
EVADLLAQIQ ASHITVERKD YLKTDISTAL KEIRSQLESH SDQNMHQAEE WFKCRYAKLT
       310        320        330        340        350        360
EAAEQNKEAI RSAKEEIAEY RRQLQSKSIE LESVRGTKES LERQLSDIEE RHNHDLSSYQ
       370        380        390        400        410        420
DTIQQLENEL RGTKWEMARH LREYQDLLNV KMALDIEIAA YRKLLEGEET RFSTFAGSIT
       430        440        450        460        470        480
GPLYTHRPPI TISSKIQKPK VEAPKLKVQH KFVEEIIEET KVEDEKSEME EALTAITEEL
       490        500        510        520        530        540
AVSMKEEKKE AAEEKEEEPE AEEEEVAAKK SPVKATAPEV KEEEGEKEEE EGQEEEEEED
       550        560        570        580        590        600
EGAKSDQAEE GGSEKEGSSE KEEGEQEEGE TEAEAEGEEA EAKEEKKVEE KSEEVATKEE
       610        620        630        640        650        660
LVADAKVEKP EKAKSPVPKS PVEEKGKSPV PKSPVEEKGK SPVPKSPVEE KGKSPVPKSP
       670        680        690        700        710        720
VEEKGKSPVS KSPVEEKAKS PVPKSPVEEA KSKAEVGKGE QKEEEEKEVK EAPKEEKVEK
       730        740        750        760        770        780
KEEKPKDVPE KKKAESPVKE EAVAEVVTIT KSVKVHLEKE TKEEGKPLQQ EKEKEKAGGE
       790        800        810        820        830        840
GGSEEEGSDK GAKGSRKEDI AVNGEVEGKE EVEQETKEKG SGREEEKGVV TNGLDLSPAD
       850        860        870        880        890        900
EKKGGDKSEE KVVVTKTVEK ITSEGGDGAT KYITKSVTVT QKVEEHEETF EEKLVSTKKV
       910
EKVTSHAIVK EVTQSD

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Evidence name
P07197-2-unknown	MSYTLD...	1		inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)
P07197-2-unknown	MSYTLD...	1		inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P07197-2-Acetylation	SYTLDS...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P07197-2-Acetylation	SYTLDS...	2	acetylation-	inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)
P07197-269-unknown	ALKEIR...	269		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9943

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...TDISTA	268	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9943
...VTQSD	916	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...VTQSD	916	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt78404

TopFIND

P07197: Neurofilament medium polypeptide

General Information

3

N-termini

2

C-termini

1

Cleavages

0

Substrates

Sequence

Isoforms

Filter Information:

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

3 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

C-termini

Cleavages

Substrates