TopFIND 4.0

P07199: Major centromere autoantigen B

General Information

Protein names
- Major centromere autoantigen B
- Centromere protein B
- CENP-B
Gene names CENPB
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID P07199

3

N-termini

2

C-termini

1

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MGPKRRQLTF REKSRIIQEV EENPDLRKGE IARRFNIPPS TLSTILKNKR AILASERKYG 
        70         80         90        100        110        120 
VASTCRKTNK LSPYDKLEGL LIAWFQQIRA AGLPVKGIIL KEKALRIAEE LGMDDFTASN 
       130        140        150        160        170        180 
GWLDRFRRRH GVVSCSGVAR ARARNAAPRT PAAPASPAAV PSEGSGGSTT GWRAREEQPP 
       190        200        210        220        230        240 
SVAEGYASQD VFSATETSLW YDFLPDQAAG LCGGDGRPRQ ATQRLSVLLC ANADGSEKLP 
       250        260        270        280        290        300 
PLVAGKSAKP RAGQAGLPCD YTANSKGGVT TQALAKYLKA LDTRMAAESR RVLLLAGRLA 
       310        320        330        340        350        360 
AQSLDTSGLR HVQLAFFPPG TVHPLERGVV QQVKGHYRQA MLLKAMAALE GQDPSGLQLG 
       370        380        390        400        410        420 
LTEALHFVAA AWQAVEPSDI AACFREAGFG GGPNATITTS LKSEGEEEEE EEEEEEEEEG 
       430        440        450        460        470        480 
EGEEEEEEGE EEEEEGGEGE ELGEEEEVEE EGDVDSDEEE EEDEESSSEG LEAEDWAQGV 
       490        500        510        520        530        540 
VEAGGSFGAY GAQEEAQCPT LHFLEGGEDS DSDSEEEDDE EEDDEDEDDD DDEEDGDEVP 
       550        560        570        580        590    
VPSFGEAMAY FAMVKRYLTS FPIDDRVQSH ILHLEHDLVH VTRKNHARQA GVRGLGHQS

Isoforms



Sequence View



Filter Information:


(REFRESH)

Directness:


Physiological Relevance:


Evidence Codes:


Methodology:


Perturbation of System:


Biological System:


Protease Assignment Confidence:


Evidence Names:


Database:


Lab:



Protein Neighborhood

Domains & Features

3 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    P07199-2-unknown MGPKRR... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    P07199-2-N,N,N-trimethylglycine GPKRRQ... 2 methylation- inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    P07199-458-unknown EEEEED... 458 inferred from cleavage unknown TopFIND Inferred from cleavage TC11093

C-termini

Cleavages

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)