P08758: Annexin A5

General Information

Protein names	- Annexin A5 - Anchorin CII - Annexin V - Annexin-5 - Calphobindin I - CBP-I - Endonexin II - Lipocortin V - Placental anticoagulant protein 4 - PP4 - Placental anticoagulant protein I - PAP-I - Thromboplastin inhibitor - Vascular anticoagulant-alpha - VAC-alpha
Gene names	ANXA5
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P08758

7 N-termini

5 C-termini

4 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAQVLRGTVT DFPGFDERAD AETLRKAMKG LGTDEESILT LLTSRSNAQR QEISAAFKTL
        70         80         90        100        110        120
FGRDLLDDLK SELTGKFEKL IVALMKPSRL YDAYELKHAL KGAGTNEKVL TEIIASRTPE
       130        140        150        160        170        180
ELRAIKQVYE EEYGSSLEDD VVGDTSGYYQ RMLVVLLQAN RDPDAGIDEA QVEQDAQALF
       190        200        210        220        230        240
QAGELKWGTD EEKFITIFGT RSVSHLRKVF DKYMTISGFQ IEETIDRETS GNLEQLLLAV
       250        260        270        280        290        300
VKSIRSIPAY LAETLYYAMK GAGTDDHTLI RVMVSRSEID LFNIRKEFRK NFATSLYSMI
       310        320
KGDTSGDYKK ALLLLCGEDD

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

7 N-termini - 5 C-termini - 4 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P08758-2-unknown	MAQVLR...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P08758-2-Acetylation	AQVLRG...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P08758-124-	AIKQVY...	124			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P08758-141-unknown	VVGDTS...	141		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2476
P08758-145-unknown	TSGYYQ...	145		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2477
P08758-176-unknown	AQALFQ...	176		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2478
P08758-281-unknown	LFNIRK...	281		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2479

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...SLEDDV	140	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2476
...DVVGDT	144	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2477
...QVEQDA	175	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2478
...RSEIDL	280	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2479
...CGEDD	320	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP6_HUMAN	140	EDDV.\|.VVGD	inferred from experiment	unknown	MEROPS	Leblanc AC	Klaiman G et al.:Targets of caspase-6 activity i... (C14.005)	18487604,
CASP6_HUMAN	144	VGDT.\|.TSGY	inferred from experiment	unknown	MEROPS	Leblanc AC	Klaiman G et al.:Targets of caspase-6 activity i... (C14.005)	18487604,
CASP6_HUMAN	175	EQDA.\|.AQAL	inferred from experiment	unknown	MEROPS	Leblanc AC	Klaiman G et al.:Targets of caspase-6 activity i... (C14.005)	18487604,
CASP6_HUMAN	280	EIDL.\|.LFNI	inferred from experiment	unknown	MEROPS	Leblanc AC	Klaiman G et al.:Targets of caspase-6 activity i... (C14.005)	18487604,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)