P09917: Arachidonate 5-lipoxygenase

General Information

Protein names	- Arachidonate 5-lipoxygenase - 5-LO - 5-lipoxygenase - 1.13.11.34
Gene names	ALOX5
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P09917

2 N-termini

3 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Arachidonate 5-lipoxygenase - Isoform 3 of Arachidonate 5-lipoxygenase - Isoform 4 of Arachidonate 5-lipoxygenase - Isoform 5 of Arachidonate 5-lipoxygenase

Sequence View

        10         20         30         40         50         60
MPSYTVTVAT GSQWFAGTDD YIYLSLVGSA GCSEKHLLDK PFYNDFERGA VDSYDVTVDE
        70         80         90        100        110        120
ELGEIQLVRI EKRKYWLNDD WYLKYITLKT PHGDYIEFPC YRWITGDVEV VLRDGRAKLA
       130        140        150        160        170        180
RDDQIHILKQ HRRKELETRQ KQYRWMEWNP GFPLSIDAKC HKDLPRDIQF DSEKGVDFVL
       190        200        210        220        230        240
NYSKAMENLF INRFMHMFQS SWNDFADFEK IFVKISNTIS ERVMNHWQED LMFGYQFLNG
       250        260        270        280        290        300
CNPVLIRRCT ELPEKLPVTT EMVECSLERQ LSLEQEVQQG NIFIVDFELL DGIDANKTDP
       310        320        330        340        350        360
CTLQFLAAPI CLLYKNLANK IVPIAIQLNQ IPGDENPIFL PSDAKYDWLL AKIWVRSSDF
       370        380        390        400        410        420
HVHQTITHLL RTHLVSEVFG IAMYRQLPAV HPIFKLLVAH VRFTIAINTK AREQLICECG
       430        440        450        460        470        480
LFDKANATGG GGHVQMVQRA MKDLTYASLC FPEAIKARGM ESKEDIPYYF YRDDGLLVWE
       490        500        510        520        530        540
AIRTFTAEVV DIYYEGDQVV EEDPELQDFV NDVYVYGMRG RKSSGFPKSV KSREQLSEYL
       550        560        570        580        590        600
TVVIFTASAQ HAAVNFGQYD WCSWIPNAPP TMRAPPPTAK GVVTIEQIVD TLPDRGRSCW
       610        620        630        640        650        660
HLGAVWALSQ FQENELFLGM YPEEHFIEKP VKEAMARFRK NLEAIVSVIA ERNKKKQLPY
       670
YYLSPDRIPN SVAI         10         20         30         40         50         60
MPSYTVTVAT GSQWFAGTDD YIYLSLVGSA GCSEKHLLDK PFYNDFERGA VDSYDVTVDE
        70         80         90        100        110        120
ELGEIQLVRI EKRKYWLNDD WYLKYITLKT PHGDYIEFPC YRWITGDVEV VLRDGRAKLA
       130        140        150        160        170        180
RDDQIHILKQ HRRKELETRQ KQYRWMEWNP GFPLSIDAKC HKDLPRDIQF DSEKGVDFVL
       190        200        210        220        230        240
NYSKAMENLF INRFMHMFQS SWNDFADFEK IFVKISNTIS ERVMNHWQED LMFGYQFLNG
       250        260        270        280        290        300
CNPVLIRRCT ELPEKLPVTT EMVECSLERQ LSLEQEVQQG NIFIVDFELL DGIDANKTDP
       310        320        330        340        350        360
CTLQFLAAPI CLLYKNLANK IVPIAIQLNQ IPGDENPIFL PSDAKYDWLL AKIWVRSSDF
       370        380        390        400        410        420
HVHQTITHLL RTHLVSEVFG IAMYRQLPAV HPIFKLLVAH VRFTIAINTK AREQLICECG
       430        440        450        460        470        480
LFDKANATGG GGHVQMVQRA MKDLTYASLC FPEAIKARGM ESKEDIPYYF YRDDGLLVWE
       490        500        510        520        530        540
AIRTFTAEVV DIYYEGDQVV EEDPELQDFV NDVYVYGMRG RKSSGFPKSV KSREQLSEYL
       550        560        570        580        590        600
TVVIFTASAQ HAAVNFGQYD WCSWIPNAPP TMRAPPPTAK GVVTIEQIVD TLPDRGRSCW
       610        620        630        640        650        660
HLGAVWALSQ FQENELFLGM YPEEHFIEKP VKEAMARFRK NLEAIVSVIA ERNKKKQLPY
       670
YYLSPDRIPN SVAI         10         20         30         40         50         60
MPSYTVTVAT GSQWFAGTDD YIYLSLVGSA GCSEKHLLDK PFYNDFERGA VDSYDVTVDE
        70         80         90        100        110        120
ELGEIQLVRI EKRKYWLNDD WYLKYITLKT PHGDYIEFPC YRWITGDVEV VLRDGRAKLA
       130        140        150        160        170        180
RDDQIHILKQ HRRKELETRQ KQYRWMEWNP GFPLSIDAKC HKDLPRDIQF DSEKGVDFVL
       190        200        210        220        230        240
NYSKAMENLF INRFMHMFQS SWNDFADFEK IFVKISNTIS ERVMNHWQED LMFGYQFLNG
       250        260        270        280        290        300
CNPVLIRRCT ELPEKLPVTT EMVECSLERQ LSLEQEVQQG NIFIVDFELL DGIDANKTDP
       310        320        330        340        350        360
CTLQFLAAPI CLLYKNLANK IVPIAIQLNQ IPGDENPIFL PSDAKYDWLL AKIWVRSSDF
       370        380        390        400        410        420
HVHQTITHLL RTHLVSEVFG IAMYRQLPAV HPIFKLLVAH VRFTIAINTK AREQLICECG
       430        440        450        460        470        480
LFDKANATGG GGHVQMVQRA MKDLTYASLC FPEAIKARGM ESKEDIPYYF YRDDGLLVWE
       490        500        510        520        530        540
AIRTFTAEVV DIYYEGDQVV EEDPELQDFV NDVYVYGMRG RKSSGFPKSV KSREQLSEYL
       550        560        570        580        590        600
TVVIFTASAQ HAAVNFGQYD WCSWIPNAPP TMRAPPPTAK GVVTIEQIVD TLPDRGRSCW
       610        620        630        640        650        660
HLGAVWALSQ FQENELFLGM YPEEHFIEKP VKEAMARFRK NLEAIVSVIA ERNKKKQLPY
       670
YYLSPDRIPN SVAI         10         20         30         40         50         60
MPSYTVTVAT GSQWFAGTDD YIYLSLVGSA GCSEKHLLDK PFYNDFERGA VDSYDVTVDE
        70         80         90        100        110        120
ELGEIQLVRI EKRKYWLNDD WYLKYITLKT PHGDYIEFPC YRWITGDVEV VLRDGRAKLA
       130        140        150        160        170        180
RDDQIHILKQ HRRKELETRQ KQYRWMEWNP GFPLSIDAKC HKDLPRDIQF DSEKGVDFVL
       190        200        210        220        230        240
NYSKAMENLF INRFMHMFQS SWNDFADFEK IFVKISNTIS ERVMNHWQED LMFGYQFLNG
       250        260        270        280        290        300
CNPVLIRRCT ELPEKLPVTT EMVECSLERQ LSLEQEVQQG NIFIVDFELL DGIDANKTDP
       310        320        330        340        350        360
CTLQFLAAPI CLLYKNLANK IVPIAIQLNQ IPGDENPIFL PSDAKYDWLL AKIWVRSSDF
       370        380        390        400        410        420
HVHQTITHLL RTHLVSEVFG IAMYRQLPAV HPIFKLLVAH VRFTIAINTK AREQLICECG
       430        440        450        460        470        480
LFDKANATGG GGHVQMVQRA MKDLTYASLC FPEAIKARGM ESKEDIPYYF YRDDGLLVWE
       490        500        510        520        530        540
AIRTFTAEVV DIYYEGDQVV EEDPELQDFV NDVYVYGMRG RKSSGFPKSV KSREQLSEYL
       550        560        570        580        590        600
TVVIFTASAQ HAAVNFGQYD WCSWIPNAPP TMRAPPPTAK GVVTIEQIVD TLPDRGRSCW
       610        620        630        640        650        660
HLGAVWALSQ FQENELFLGM YPEEHFIEKP VKEAMARFRK NLEAIVSVIA ERNKKKQLPY
       670
YYLSPDRIPN SVAI

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

2 N-termini - 3 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P09917-1-unknown	MPSYTV...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P09917-1-unknown	MPSYTV...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt79785
P09917-1-unknown	MPSYTV...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt79786
P09917-1-unknown	MPSYTV...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt79787
P09917-1-unknown	MPSYTV...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt79788
P09917-172-unknown	SEKGVD...	172	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2480
P09917-172-unknown	SEKGVD...	172	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt145598
P09917-172-unknown	SEKGVD...	172	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt145599
P09917-172-unknown	SEKGVD...	172	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt145600
P09917-172-unknown	SEKGVD...	172	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt145602

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...DIQFDS	171	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2480
...DIQFDS	171	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128896
...DIQFDS	171	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128897
...DIQFDS	171	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128898
...DIQFDS	171	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128900
...EAIRTF	484	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt75406
...EAIRTF	484	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt92907
...EAIRTF	484	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt92908
...NSVAI	674	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...NSVAI	674	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt75403
...NSVAI	674	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt75404

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP6_HUMAN	171	QFDS.\|.SEKG	inferred from experiment	unknown	MEROPS	Steinhilber D	Werz O et al.:Caspase-mediated degradation of... (C14.005)	16135563,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)