P10827: Thyroid hormone receptor alpha

General Information

Protein names	- Thyroid hormone receptor alpha - Nuclear receptor subfamily 1 group A member 1 - V-erbA-related protein 7 - EAR-7 - c-erbA-1 - c-erbA-alpha
Gene names	THRA
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P10827

2 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform Alpha-1 of Thyroid hormone receptor alpha - Isoform Alpha-3 of Thyroid hormone receptor alpha - Isoform Alpha-4 of Thyroid hormone receptor alpha

Sequence View

        10         20         30         40         50         60
MEQKPSKVEC GSDPEENSAR SPDGKRKRKN GQCSLKTSMS GYIPSYLDKD EQCVVCGDKA
        70         80         90        100        110        120
TGYHYRCITC EGCKGFFRRT IQKNLHPTYS CKYDSCCVID KITRNQCQLC RFKKCIAVGM
       130        140        150        160        170        180
AMDLVLDDSK RVAKRKLIEQ NRERRRKEEM IRSLQQRPEP TPEEWDLIHI ATEAHRSTNA
       190        200        210        220        230        240
QGSHWKQRRK FLPDDIGQSP IVSMPDGDKV DLEAFSEFTK IITPAITRVV DFAKKLPMFS
       250        260        270        280        290        300
ELPCEDQIIL LKGCCMEIMS LRAAVRYDPE SDTLTLSGEM AVKREQLKNG GLGVVSDAIF
       310        320        330        340        350        360
ELGKSLSAFN LDDTEVALLQ AVLLMSTDRS GLLCVDKIEK SQEAYLLAFE HYVNHRKHNI
       370        380        390        400        410        420
PHFWPKLLMK EREVQSSILY KGAAAEGRPG GSLGVHPEGQ QLLGMHVVQG PQVRQLEQQL
       430        440        450        460        470        480
GEAGSLQGPV LQHQSPKSPQ QRLLELLHRS GILHARAVCG EDDSSEADSP SSSEEEPEVC
       490
EDLAGNAASP         10         20         30         40         50         60
MEQKPSKVEC GSDPEENSAR SPDGKRKRKN GQCSLKTSMS GYIPSYLDKD EQCVVCGDKA
        70         80         90        100        110        120
TGYHYRCITC EGCKGFFRRT IQKNLHPTYS CKYDSCCVID KITRNQCQLC RFKKCIAVGM
       130        140        150        160        170        180
AMDLVLDDSK RVAKRKLIEQ NRERRRKEEM IRSLQQRPEP TPEEWDLIHI ATEAHRSTNA
       190        200        210        220        230        240
QGSHWKQRRK FLPDDIGQSP IVSMPDGDKV DLEAFSEFTK IITPAITRVV DFAKKLPMFS
       250        260        270        280        290        300
ELPCEDQIIL LKGCCMEIMS LRAAVRYDPE SDTLTLSGEM AVKREQLKNG GLGVVSDAIF
       310        320        330        340        350        360
ELGKSLSAFN LDDTEVALLQ AVLLMSTDRS GLLCVDKIEK SQEAYLLAFE HYVNHRKHNI
       370        380        390        400        410        420
PHFWPKLLMK EREVQSSILY KGAAAEGRPG GSLGVHPEGQ QLLGMHVVQG PQVRQLEQQL
       430        440        450        460        470        480
GEAGSLQGPV LQHQSPKSPQ QRLLELLHRS GILHARAVCG EDDSSEADSP SSSEEEPEVC
       490
EDLAGNAASP         10         20         30         40         50         60
MEQKPSKVEC GSDPEENSAR SPDGKRKRKN GQCSLKTSMS GYIPSYLDKD EQCVVCGDKA
        70         80         90        100        110        120
TGYHYRCITC EGCKGFFRRT IQKNLHPTYS CKYDSCCVID KITRNQCQLC RFKKCIAVGM
       130        140        150        160        170        180
AMDLVLDDSK RVAKRKLIEQ NRERRRKEEM IRSLQQRPEP TPEEWDLIHI ATEAHRSTNA
       190        200        210        220        230        240
QGSHWKQRRK FLPDDIGQSP IVSMPDGDKV DLEAFSEFTK IITPAITRVV DFAKKLPMFS
       250        260        270        280        290        300
ELPCEDQIIL LKGCCMEIMS LRAAVRYDPE SDTLTLSGEM AVKREQLKNG GLGVVSDAIF
       310        320        330        340        350        360
ELGKSLSAFN LDDTEVALLQ AVLLMSTDRS GLLCVDKIEK SQEAYLLAFE HYVNHRKHNI
       370        380        390        400        410        420
PHFWPKLLMK EREVQSSILY KGAAAEGRPG GSLGVHPEGQ QLLGMHVVQG PQVRQLEQQL
       430        440        450        460        470        480
GEAGSLQGPV LQHQSPKSPQ QRLLELLHRS GILHARAVCG EDDSSEADSP SSSEEEPEVC
       490
EDLAGNAASP

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

2 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P10827-1-unknown	MEQKPS...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P10827-1-unknown	MEQKPS...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt92078
P10827-1-unknown	MEQKPS...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt92079
P10827-1-unknown	MEQKPS...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt92080
P10827-452-unknown	ILHARA...	452	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9980
P10827-452-unknown	ILHARA...	452	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt152165
P10827-452-unknown	ILHARA...	452	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt152216

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...LHRSGI	451	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9980
...LHRSGI	451	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135575
...LHRSGI	451	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135626
...NAASP	490	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...NAASP	490	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt87698
...NAASP	490	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt87697

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAA_HUMAN	451	RSGI.\|.ILHA	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)