P12955: Xaa-Pro dipeptidase

General Information

Protein names	- Xaa-Pro dipeptidase - X-Pro dipeptidase - 3.4.13.9 - Imidodipeptidase - Peptidase D - Proline dipeptidase - Prolidase
Gene names	PEPD
Organism	Homo sapiens
Protease Family
Protease ID	M24.007
Chromosome location
UniProt ID	P12955

5 N-termini

1 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Xaa-Pro dipeptidase - Isoform 3 of Xaa-Pro dipeptidase

Sequence View

        10         20         30         40         50         60
MAAATGPSFW LGNETLKVPL ALFALNRQRL CERLRKNPAV QAGSIVVLQG GEETQRYCTD
        70         80         90        100        110        120
TGVLFRQESF FHWAFGVTEP GCYGVIDVDT GKSTLFVPRL PASHATWMGK IHSKEHFKEK
       130        140        150        160        170        180
YAVDDVQYVD EIASVLTSQK PSVLLTLRGV NTDSGSVCRE ASFDGISKFE VNNTILHPEI
       190        200        210        220        230        240
VECRVFKTDM ELEVLRYTNK ISSEAHREVM KAVKVGMKEY ELESLFEHYC YSRGGMRHSS
       250        260        270        280        290        300
YTCICGSGEN SAVLHYGHAG APNDRTIQNG DMCLFDMGGE YYCFASDITC SFPANGKFTA
       310        320        330        340        350        360
DQKAVYEAVL RSSRAVMGAM KPGVWWPDMH RLADRIHLEE LAHMGILSGS VDAMVQAHLG
       370        380        390        400        410        420
AVFMPHGLGH FLGIDVHDVG GYPEGVERID EPGLRSLRTA RHLQPGMVLT VEPGIYFIDH
       430        440        450        460        470        480
LLDEALADPA RASFLNREVL QRFRGFGGVR IEEDVVVTDS GIELLTCVPR TVEEIEACMA
       490
GCDKAFTPFS GPK         10         20         30         40         50         60
MAAATGPSFW LGNETLKVPL ALFALNRQRL CERLRKNPAV QAGSIVVLQG GEETQRYCTD
        70         80         90        100        110        120
TGVLFRQESF FHWAFGVTEP GCYGVIDVDT GKSTLFVPRL PASHATWMGK IHSKEHFKEK
       130        140        150        160        170        180
YAVDDVQYVD EIASVLTSQK PSVLLTLRGV NTDSGSVCRE ASFDGISKFE VNNTILHPEI
       190        200        210        220        230        240
VECRVFKTDM ELEVLRYTNK ISSEAHREVM KAVKVGMKEY ELESLFEHYC YSRGGMRHSS
       250        260        270        280        290        300
YTCICGSGEN SAVLHYGHAG APNDRTIQNG DMCLFDMGGE YYCFASDITC SFPANGKFTA
       310        320        330        340        350        360
DQKAVYEAVL RSSRAVMGAM KPGVWWPDMH RLADRIHLEE LAHMGILSGS VDAMVQAHLG
       370        380        390        400        410        420
AVFMPHGLGH FLGIDVHDVG GYPEGVERID EPGLRSLRTA RHLQPGMVLT VEPGIYFIDH
       430        440        450        460        470        480
LLDEALADPA RASFLNREVL QRFRGFGGVR IEEDVVVTDS GIELLTCVPR TVEEIEACMA
       490
GCDKAFTPFS GPK

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

5 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P12955-1-unknown	MAAATG...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt84867
P12955-1-unknown	MAAATG...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt84868
P12955-2-unknown	MAAATG...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P12955-2-Acetylation	AAATGP...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P12955-2-Acetylation	AAATGP...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
P12955-2-Acetylation	AAATGP...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt111184
P12955-2-Acetylation	AAATGP...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt111185
P12955-251-unknown	SAVLHY...	251		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt172511
P12955-251-unknown	SAVLHY...	251		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt172512
P12955-251-	SAVLHY...	251			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...FSGPK	493	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...FSGPK	493	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt80486
...FSGPK	493	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt80485
...FSGPK	493		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)