P15498: Proto-oncogene vav

General Information

Protein names	- Proto-oncogene vav
Gene names	VAV1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P15498

4 N-termini

4 C-termini

3 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MELWRQCTHW LIQCRVLPPS HRVTWDGAQV CELAQALRDG VLLCQLLNNL LPHAINLREV
        70         80         90        100        110        120
NLRPQMSQFL CLKNIRTFLS TCCEKFGLKR SELFEAFDLF DVQDFGKVIY TLSALSWTPI
       130        140        150        160        170        180
AQNRGIMPFP TEEESVGDED IYSGLSDQID DTVEEDEDLY DCVENEEAEG DEIYEDLMRS
       190        200        210        220        230        240
EPVSMPPKMT EYDKRCCCLR EIQQTEEKYT DTLGSIQQHF LKPLQRFLKP QDIEIIFINI
       250        260        270        280        290        300
EDLLRVHTHF LKEMKEALGT PGAANLYQVF IKYKERFLVY GRYCSQVESA SKHLDRVAAA
       310        320        330        340        350        360
REDVQMKLEE CSQRANNGRF TLRDLLMVPM QRVLKYHLLL QELVKHTQEA MEKENLRLAL
       370        380        390        400        410        420
DAMRDLAQCV NEVKRDNETL RQITNFQLSI ENLDQSLAHY GRPKIDGELK ITSVERRSKM
       430        440        450        460        470        480
DRYAFLLDKA LLICKRRGDS YDLKDFVNLH SFQVRDDSSG DRDNKKWSHM FLLIEDQGAQ
       490        500        510        520        530        540
GYELFFKTRE LKKKWMEQFE MAISNIYPEN ATANGHDFQM FSFEETTSCK ACQMLLRGTF
       550        560        570        580        590        600
YQGYRCHRCR ASAHKECLGR VPPCGRHGQD FPGTMKKDKL HRRAQDKKRN ELGLPKMEVF
       610        620        630        640        650        660
QEYYGLPPPP GAIGPFLRLN PGDIVELTKA EAEQNWWEGR NTSTNEIGWF PCNRVKPYVH
       670        680        690        700        710        720
GPPQDLSVHL WYAGPMERAG AESILANRSD GTFLVRQRVK DAAEFAISIK YNVEVKHIKI
       730        740        750        760        770        780
MTAEGLYRIT EKKAFRGLTE LVEFYQQNSL KDCFKSLDTT LQFPFKEPEK RTISRPAVGS
       790        800        810        820        830        840
TKYFGTAKAR YDFCARDRSE LSLKEGDIIK ILNKKGQQGW WRGEIYGRVG WFPANYVEED

YSEYC

Isoforms

- Isoform 2 of Proto-oncogene vav

Sequence View

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Evidence Names:

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Protein Neighborhood

Domains & Features

4 N-termini - 4 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P15498-1-unknown	MELWRQ...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P15498-1-unknown	MELWRQ...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt94075
P15498-151-unknown	DTVEED...	151	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1659
P15498-151-unknown	DTVEED...	151	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt144781
P15498-162-unknown	CVENEE...	162	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1661
P15498-162-unknown	CVENEE...	162	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt145230
P15498-172-unknown	EIYEDL...	172	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11230

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...SDQIDD	150	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1659
...SDQIDD	150	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128056
...EDLYDC	161	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1661
...EDLYDC	161	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128519
...EAEGDE	171	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11230
...EAEGDE	171	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128913
...YSEYC	845	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...YSEYC	845	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt89693

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP3_HUMAN	150	QIDD.\|.DTVE	inferred from experiment	unknown	MEROPS	Schmitz ML	Hofmann TG et al.:Caspase-dependent cleavage and ... (C14.003)	10713703,
CASP3_HUMAN	161	LYDC.\|.CVEN	inferred from experiment	unknown	MEROPS	Schmitz ML	Hofmann TG et al.:Caspase-dependent cleavage and ... (C14.003)	10713703,
GRAB_HUMAN	171	EGDE.\|.EIYE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)