P16092: Fibroblast growth factor receptor 1

General Information

Protein names	- Fibroblast growth factor receptor 1 - FGFR-1 - bFGF-R-1 - 2.7.10.1 {ECO:0000250\|UniProtKB:P11362} - Basic fibroblast growth factor receptor 1 - MFR - Proto-oncogene c-Fgr - CD331
Gene names	Fgfr1
Organism	Mus musculus
Protease Family
Protease ID	I43.001
Chromosome location
UniProt ID	P16092

3 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Fibroblast growth factor receptor 1 - Isoform 3 of Fibroblast growth factor receptor 1 - Isoform 4 of Fibroblast growth factor receptor 1 - Isoform 5 of Fibroblast growth factor receptor 1 - Isoform 6 of Fibroblast growth factor receptor 1

Sequence View

        10         20         30         40         50         60
MWGWKCLLFW AVLVTATLCT ARPAPTLPEQ AQPWGVPVEV ESLLVHPGDL LQLRCRLRDD
        70         80         90        100        110        120
VQSINWLRDG VQLVESNRTR ITGEEVEVRD SIPADSGLYA CVTSSPSGSD TTYFSVNVSD
       130        140        150        160        170        180
ALPSSEDDDD DDDSSSEEKE TDNTKPNRRP VAPYWTSPEK MEKKLHAVPA AKTVKFKCPS
       190        200        210        220        230        240
SGTPNPTLRW LKNGKEFKPD HRIGGYKVRY ATWSIIMDSV VPSDKGNYTC IVENEYGSIN
       250        260        270        280        290        300
HTYQLDVVER SPHRPILQAG LPANKTVALG SNVEFMCKVY SDPQPHIQWL KHIEVNGSKI
       310        320        330        340        350        360
GPDNLPYVQI LKTAGVNTTD KEMEVLHLRN VSFEDAGEYT CLAGNSIGLS HHSAWLTVLE
       370        380        390        400        410        420
ALEERPAVMT SPLYLEIIIY CTGAFLISCM LGSVIIYKMK SGTKKSDFHS QMAVHKLAKS
       430        440        450        460        470        480
IPLRRQVTVS ADSSASMNSG VLLVRPSRLS SSGTPMLAGV SEYELPEDPR WELPRDRLVL
       490        500        510        520        530        540
GKPLGEGCFG QVVLAEAIGL DKDKPNRVTK VAVKMLKSDA TEKDLSDLIS EMEMMKMIGK
       550        560        570        580        590        600
HKNIINLLGA CTQDGPLYVI VEYASKGNLR EYLQARRPPG LEYCYNPSHN PEEQLSSKDL
       610        620        630        640        650        660
VSCAYQVARG MEYLASKKCI HRDLAARNVL VTEDNVMKIA DFGLARDIHH IDYYKKTTNG
       670        680        690        700        710        720
RLPVKWMAPE ALFDRIYTHQ SDVWSFGVLL WEIFTLGGSP YPGVPVEELF KLLKEGHRMD
       730        740        750        760        770        780
KPSNCTNELY MMMRDCWHAV PSQRPTFKQL VEDLDRIVAL TSNQEYLDLS IPLDQYSPSF
       790        800        810        820
PDTRSSTCSS GEDSVFSHEP LPEEPCLPRH PTQLANSGLK RR         10         20         30         40         50         60
MWGWKCLLFW AVLVTATLCT ARPAPTLPEQ AQPWGVPVEV ESLLVHPGDL LQLRCRLRDD
        70         80         90        100        110        120
VQSINWLRDG VQLVESNRTR ITGEEVEVRD SIPADSGLYA CVTSSPSGSD TTYFSVNVSD
       130        140        150        160        170        180
ALPSSEDDDD DDDSSSEEKE TDNTKPNRRP VAPYWTSPEK MEKKLHAVPA AKTVKFKCPS
       190        200        210        220        230        240
SGTPNPTLRW LKNGKEFKPD HRIGGYKVRY ATWSIIMDSV VPSDKGNYTC IVENEYGSIN
       250        260        270        280        290        300
HTYQLDVVER SPHRPILQAG LPANKTVALG SNVEFMCKVY SDPQPHIQWL KHIEVNGSKI
       310        320        330        340        350        360
GPDNLPYVQI LKTAGVNTTD KEMEVLHLRN VSFEDAGEYT CLAGNSIGLS HHSAWLTVLE
       370        380        390        400        410        420
ALEERPAVMT SPLYLEIIIY CTGAFLISCM LGSVIIYKMK SGTKKSDFHS QMAVHKLAKS
       430        440        450        460        470        480
IPLRRQVTVS ADSSASMNSG VLLVRPSRLS SSGTPMLAGV SEYELPEDPR WELPRDRLVL
       490        500        510        520        530        540
GKPLGEGCFG QVVLAEAIGL DKDKPNRVTK VAVKMLKSDA TEKDLSDLIS EMEMMKMIGK
       550        560        570        580        590        600
HKNIINLLGA CTQDGPLYVI VEYASKGNLR EYLQARRPPG LEYCYNPSHN PEEQLSSKDL
       610        620        630        640        650        660
VSCAYQVARG MEYLASKKCI HRDLAARNVL VTEDNVMKIA DFGLARDIHH IDYYKKTTNG
       670        680        690        700        710        720
RLPVKWMAPE ALFDRIYTHQ SDVWSFGVLL WEIFTLGGSP YPGVPVEELF KLLKEGHRMD
       730        740        750        760        770        780
KPSNCTNELY MMMRDCWHAV PSQRPTFKQL VEDLDRIVAL TSNQEYLDLS IPLDQYSPSF
       790        800        810        820
PDTRSSTCSS GEDSVFSHEP LPEEPCLPRH PTQLANSGLK RR         10         20         30         40         50         60
MWGWKCLLFW AVLVTATLCT ARPAPTLPEQ AQPWGVPVEV ESLLVHPGDL LQLRCRLRDD
        70         80         90        100        110        120
VQSINWLRDG VQLVESNRTR ITGEEVEVRD SIPADSGLYA CVTSSPSGSD TTYFSVNVSD
       130        140        150        160        170        180
ALPSSEDDDD DDDSSSEEKE TDNTKPNRRP VAPYWTSPEK MEKKLHAVPA AKTVKFKCPS
       190        200        210        220        230        240
SGTPNPTLRW LKNGKEFKPD HRIGGYKVRY ATWSIIMDSV VPSDKGNYTC IVENEYGSIN
       250        260        270        280        290        300
HTYQLDVVER SPHRPILQAG LPANKTVALG SNVEFMCKVY SDPQPHIQWL KHIEVNGSKI
       310        320        330        340        350        360
GPDNLPYVQI LKTAGVNTTD KEMEVLHLRN VSFEDAGEYT CLAGNSIGLS HHSAWLTVLE
       370        380        390        400        410        420
ALEERPAVMT SPLYLEIIIY CTGAFLISCM LGSVIIYKMK SGTKKSDFHS QMAVHKLAKS
       430        440        450        460        470        480
IPLRRQVTVS ADSSASMNSG VLLVRPSRLS SSGTPMLAGV SEYELPEDPR WELPRDRLVL
       490        500        510        520        530        540
GKPLGEGCFG QVVLAEAIGL DKDKPNRVTK VAVKMLKSDA TEKDLSDLIS EMEMMKMIGK
       550        560        570        580        590        600
HKNIINLLGA CTQDGPLYVI VEYASKGNLR EYLQARRPPG LEYCYNPSHN PEEQLSSKDL
       610        620        630        640        650        660
VSCAYQVARG MEYLASKKCI HRDLAARNVL VTEDNVMKIA DFGLARDIHH IDYYKKTTNG
       670        680        690        700        710        720
RLPVKWMAPE ALFDRIYTHQ SDVWSFGVLL WEIFTLGGSP YPGVPVEELF KLLKEGHRMD
       730        740        750        760        770        780
KPSNCTNELY MMMRDCWHAV PSQRPTFKQL VEDLDRIVAL TSNQEYLDLS IPLDQYSPSF
       790        800        810        820
PDTRSSTCSS GEDSVFSHEP LPEEPCLPRH PTQLANSGLK RR         10         20         30         40         50         60
MWGWKCLLFW AVLVTATLCT ARPAPTLPEQ AQPWGVPVEV ESLLVHPGDL LQLRCRLRDD
        70         80         90        100        110        120
VQSINWLRDG VQLVESNRTR ITGEEVEVRD SIPADSGLYA CVTSSPSGSD TTYFSVNVSD
       130        140        150        160        170        180
ALPSSEDDDD DDDSSSEEKE TDNTKPNRRP VAPYWTSPEK MEKKLHAVPA AKTVKFKCPS
       190        200        210        220        230        240
SGTPNPTLRW LKNGKEFKPD HRIGGYKVRY ATWSIIMDSV VPSDKGNYTC IVENEYGSIN
       250        260        270        280        290        300
HTYQLDVVER SPHRPILQAG LPANKTVALG SNVEFMCKVY SDPQPHIQWL KHIEVNGSKI
       310        320        330        340        350        360
GPDNLPYVQI LKTAGVNTTD KEMEVLHLRN VSFEDAGEYT CLAGNSIGLS HHSAWLTVLE
       370        380        390        400        410        420
ALEERPAVMT SPLYLEIIIY CTGAFLISCM LGSVIIYKMK SGTKKSDFHS QMAVHKLAKS
       430        440        450        460        470        480
IPLRRQVTVS ADSSASMNSG VLLVRPSRLS SSGTPMLAGV SEYELPEDPR WELPRDRLVL
       490        500        510        520        530        540
GKPLGEGCFG QVVLAEAIGL DKDKPNRVTK VAVKMLKSDA TEKDLSDLIS EMEMMKMIGK
       550        560        570        580        590        600
HKNIINLLGA CTQDGPLYVI VEYASKGNLR EYLQARRPPG LEYCYNPSHN PEEQLSSKDL
       610        620        630        640        650        660
VSCAYQVARG MEYLASKKCI HRDLAARNVL VTEDNVMKIA DFGLARDIHH IDYYKKTTNG
       670        680        690        700        710        720
RLPVKWMAPE ALFDRIYTHQ SDVWSFGVLL WEIFTLGGSP YPGVPVEELF KLLKEGHRMD
       730        740        750        760        770        780
KPSNCTNELY MMMRDCWHAV PSQRPTFKQL VEDLDRIVAL TSNQEYLDLS IPLDQYSPSF
       790        800        810        820
PDTRSSTCSS GEDSVFSHEP LPEEPCLPRH PTQLANSGLK RR         10         20         30         40         50         60
MWGWKCLLFW AVLVTATLCT ARPAPTLPEQ AQPWGVPVEV ESLLVHPGDL LQLRCRLRDD
        70         80         90        100        110        120
VQSINWLRDG VQLVESNRTR ITGEEVEVRD SIPADSGLYA CVTSSPSGSD TTYFSVNVSD
       130        140        150        160        170        180
ALPSSEDDDD DDDSSSEEKE TDNTKPNRRP VAPYWTSPEK MEKKLHAVPA AKTVKFKCPS
       190        200        210        220        230        240
SGTPNPTLRW LKNGKEFKPD HRIGGYKVRY ATWSIIMDSV VPSDKGNYTC IVENEYGSIN
       250        260        270        280        290        300
HTYQLDVVER SPHRPILQAG LPANKTVALG SNVEFMCKVY SDPQPHIQWL KHIEVNGSKI
       310        320        330        340        350        360
GPDNLPYVQI LKTAGVNTTD KEMEVLHLRN VSFEDAGEYT CLAGNSIGLS HHSAWLTVLE
       370        380        390        400        410        420
ALEERPAVMT SPLYLEIIIY CTGAFLISCM LGSVIIYKMK SGTKKSDFHS QMAVHKLAKS
       430        440        450        460        470        480
IPLRRQVTVS ADSSASMNSG VLLVRPSRLS SSGTPMLAGV SEYELPEDPR WELPRDRLVL
       490        500        510        520        530        540
GKPLGEGCFG QVVLAEAIGL DKDKPNRVTK VAVKMLKSDA TEKDLSDLIS EMEMMKMIGK
       550        560        570        580        590        600
HKNIINLLGA CTQDGPLYVI VEYASKGNLR EYLQARRPPG LEYCYNPSHN PEEQLSSKDL
       610        620        630        640        650        660
VSCAYQVARG MEYLASKKCI HRDLAARNVL VTEDNVMKIA DFGLARDIHH IDYYKKTTNG
       670        680        690        700        710        720
RLPVKWMAPE ALFDRIYTHQ SDVWSFGVLL WEIFTLGGSP YPGVPVEELF KLLKEGHRMD
       730        740        750        760        770        780
KPSNCTNELY MMMRDCWHAV PSQRPTFKQL VEDLDRIVAL TSNQEYLDLS IPLDQYSPSF
       790        800        810        820
PDTRSSTCSS GEDSVFSHEP LPEEPCLPRH PTQLANSGLK RR

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

3 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P16092-1-unknown	MWGWKC...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt75121
P16092-1-unknown	MWGWKC...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt75122
P16092-1-unknown	MWGWKC...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt75123
P16092-1-unknown	MWGWKC...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt75124
P16092-1-unknown	MWGWKC...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt75125
P16092-22-unknown	RPAPTL...	22	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P16092-22-unknown	RPAPTL...	22	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt112934
P16092-433-unknown	SSASMN...	433	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32313
P16092-433-unknown	SSASMN...	433	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt150774
P16092-433-unknown	SSASMN...	433	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt150819
P16092-433-unknown	SSASMN...	433	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt150820
P16092-433-unknown	SSASMN...	433	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt152480
P16092-433-unknown	SSASMN...	433	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt152680

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...TVSADS	432	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32313
...TVSADS	432	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134176
...TVSADS	432	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134221
...TVSADS	432	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134222
...TVSADS	432	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135891
...TVSADS	432	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136099
...GLKRR	822	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...GLKRR	822	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt70741
...GLKRR	822	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt70739
...GLKRR	822	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt70742
...GLKRR	822	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt70743
...GLKRR	822	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt70740

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_MOUSE	432	SADS.\|.SSAS	inferred from experiment	unknown	MEROPS	Craik CS	Loeb CR et al.:Granzyme B proteolyzes receptor... (S01.136)	16798735,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)