P17542: T-cell acute lymphocytic leukemia protein 1

General Information

Protein names	- T-cell acute lymphocytic leukemia protein 1 - TAL-1 - Class A basic helix-loop-helix protein 17 - bHLHa17 - Stem cell protein - T-cell leukemia/lymphoma protein 5
Gene names	TAL1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P17542

10 N-termini

3 C-termini

6 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform PP39-TAL1 of T-cell acute lymphocytic leukemia protein 1 - Isoform PP22-TAL1 of T-cell acute lymphocytic leukemia protein 1

Sequence View

        10         20         30         40         50         60
MTERPPSEAA RSDPQLEGRD AAEASMAPPH LVLLNGVAKE TSRAAAAEPP VIELGARGGP
        70         80         90        100        110        120
GGGPAGGGGA ARDLKGRDAA TAEARHRVPT TELCRPPGPA PAPAPASVTA ELPGDGRMVQ
       130        140        150        160        170        180
LSPPALAAPA APGRALLYSL SQPLASLGSG FFGEPDAFPM FTTNNRVKRR PSPYEMEITD
       190        200        210        220        230        240
GPHTKVVRRI FTNSRERWRQ QNVNGAFAEL RKLIPTHPPD KKLSKNEILR LAMKYINFLA
       250        260        270        280        290        300
KLLNDQEEEG TQRAKTGKDP VVGAGGGGGG GGGGAPPDDL LQDVLSPNSS CGSSLDGAAS
       310        320        330
PDSYTEEPAP KHTARSLHPA MLPAADGAGP R         10         20         30         40         50         60
MTERPPSEAA RSDPQLEGRD AAEASMAPPH LVLLNGVAKE TSRAAAAEPP VIELGARGGP
        70         80         90        100        110        120
GGGPAGGGGA ARDLKGRDAA TAEARHRVPT TELCRPPGPA PAPAPASVTA ELPGDGRMVQ
       130        140        150        160        170        180
LSPPALAAPA APGRALLYSL SQPLASLGSG FFGEPDAFPM FTTNNRVKRR PSPYEMEITD
       190        200        210        220        230        240
GPHTKVVRRI FTNSRERWRQ QNVNGAFAEL RKLIPTHPPD KKLSKNEILR LAMKYINFLA
       250        260        270        280        290        300
KLLNDQEEEG TQRAKTGKDP VVGAGGGGGG GGGGAPPDDL LQDVLSPNSS CGSSLDGAAS
       310        320        330
PDSYTEEPAP KHTARSLHPA MLPAADGAGP R

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

10 N-termini - 3 C-termini - 6 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P17542-1-	MTERPP...	1		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P17542-1-unknown	MTERPP...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P17542-26-unknown	MAPPHL...	26	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt91492
P17542-27-unknown	APPHLV...	27		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P17542-27-unknown	APPHLV...	27	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt160350
P17542-27-	APPHLV...	27		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P17542-93-	LCRPPG...	93		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P17542-93-unknown	LCRPPG...	93	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt172553
P17542-176-unknown	MEITDG...	176	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt91493
P17542-176-unknown	MEITDG...	176	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt101653
P17542-181-unknown	GPHTKV...	181	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2825
P17542-181-unknown	GPHTKV...	181	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1671
P17542-181-unknown	GPHTKV...	181	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3057
P17542-181-unknown	GPHTKV...	181	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt144969
P17542-181-unknown	GPHTKV...	181	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt197679
P17542-297-unknown	GAASPD...	297	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2827
P17542-297-unknown	GAASPD...	297	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1673
P17542-297-unknown	GAASPD...	297	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3059
P17542-297-unknown	GAASPD...	297	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt143551
P17542-297-unknown	GAASPD...	297	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt149153

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...MEITDG	180	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2825
...MEITDG	180	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1671
...MEITDG	180	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3057
...MEITDG	180	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128246
...GSSLDG	296	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2827
...GSSLDG	296	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1673
...GSSLDG	296	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3059
...GSSLDG	296	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126791
...GSSLDG	296	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132538
...GAGPR	331	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...GAGPR	331	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt87111
...GAGPR	331	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt87110

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP7_HUMAN	180	ITDG.\|.GPHT	inferred from experiment	unknown	MEROPS	De Maria R	Zeuner A et al.:Control of erythroid cell produ... (C14.003)	12867998,
CASP3_HUMAN	180	ITDG.\|.GPHT	inferred from experiment	unknown	MEROPS	De Maria R	Zeuner A et al.:Control of erythroid cell produ... (C14.003)	12867998,
CASP8_HUMAN	180	ITDG.\|.GPHT	inferred from experiment	unknown	MEROPS	De Maria R	Zeuner A et al.:Control of erythroid cell produ... (C14.003)	12867998,
CASP7_HUMAN	296	SLDG.\|.GAAS	inferred from experiment	unknown	MEROPS	De Maria R	Zeuner A et al.:Control of erythroid cell produ... (C14.003)	12867998,
CASP3_HUMAN	296	SLDG.\|.GAAS	inferred from experiment	unknown	MEROPS	De Maria R	Zeuner A et al.:Control of erythroid cell produ... (C14.003)	12867998,
CASP8_HUMAN	296	SLDG.\|.GAAS	inferred from experiment	unknown	MEROPS	De Maria R	Zeuner A et al.:Control of erythroid cell produ... (C14.003)	12867998,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)