P19012: Keratin, type I cytoskeletal 15

General Information

Protein names	- Keratin, type I cytoskeletal 15 - Cytokeratin-15 - CK-15 - Keratin-15 - K15
Gene names	KRT15
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P19012

4 N-termini

5 C-termini

3 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MTTTFLQTSS STFGGGSTRG GSLLAGGGGF GGGSLSGGGG SRSISASSAR FVSSGSGGGY
        70         80         90        100        110        120
GGGMRVCGFG GGAGSVFGGG FGGGVGGGFG GGFGGGDGGL LSGNEKITMQ NLNDRLASYL
       130        140        150        160        170        180
DKVRALEEAN ADLEVKIHDW YQKQTPTSPE CDYSQYFKTI EELRDKIMAT TIDNSRVILE
       190        200        210        220        230        240
IDNARLAADD FRLKYENELA LRQGVEADIN GLRRVLDELT LARTDLEMQI EGLNEELAYL
       250        260        270        280        290        300
KKNHEEEMKE FSSQLAGQVN VEMDAAPGVD LTRVLAEMRE QYEAMAEKNR RDVEAWFFSK
       310        320        330        340        350        360
TEELNKEVAS NTEMIQTSKT EITDLRRTMQ ELEIELQSQL SMKAGLENSL AETECRYATQ
       370        380        390        400        410        420
LQQIQGLIGG LEAQLSELRC EMEAQNQEYK MLLDIKTRLE QEIATYRSLL EGQDAKMAGI
       430        440        450
AIREASSGGG GSSSNFHINV EESVDGQVVS SHKREI

Isoforms

- Isoform 2 of Keratin, type I cytoskeletal 15

Sequence View

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Protein Neighborhood

Domains & Features

4 N-termini - 5 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P19012-1-unknown	MTTTFL...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P19012-2-acetylation	TTTFLQ...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P19012-265-unknown	AAPGVD...	265		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2545
P19012-446-unknown	GQVVSS...	446		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2830
P19012-446-unknown	GQVVSS...	446		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1677

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...NVEMDA	264	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2545
...EMEAQN	385	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000409282
...GQDAKM	416	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000377550
...EESVDG	445	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2830
...EESVDG	445	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1677
...HKREI	456	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP6_HUMAN	264	EMDA.\|.AAPG	inferred from experiment	unknown	MEROPS	Otto A	Badock V et al.:Apoptosis-induced cleavage of k... (C14.003)	11319614,
CASP7_HUMAN	445	SVDG.\|.GQVV	inferred from experiment	unknown	MEROPS	Otto A	Badock V et al.:Apoptosis-induced cleavage of k... (C14.003)	11319614,
CASP3_HUMAN	445	SVDG.\|.GQVV	inferred from experiment	unknown	MEROPS	Otto A	Badock V et al.:Apoptosis-induced cleavage of k... (C14.003)	11319614,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)