P19022: Cadherin-2

General Information

Protein names	- Cadherin-2 - CDw325 - Neural cadherin - N-cadherin {ECO:0000303\|PubMed:2216790} - CD325
Gene names	CDH2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P19022

5 N-termini

6 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MCRIAGALRT LLPLLAALLQ ASVEASGEIA LCKTGFPEDV YSAVLSKDVH EGQPLLNVKF
        70         80         90        100        110        120
SNCNGKRKVQ YESSEPADFK VDEDGMVYAV RSFPLSSEHA KFLIYAQDKE TQEKWQVAVK
       130        140        150        160        170        180
LSLKPTLTEE SVKESAEVEE IVFPRQFSKH SGHLQRQKRD WVIPPINLPE NSRGPFPQEL
       190        200        210        220        230        240
VRIRSDRDKN LSLRYSVTGP GADQPPTGIF IINPISGQLS VTKPLDREQI ARFHLRAHAV
       250        260        270        280        290        300
DINGNQVENP IDIVINVIDM NDNRPEFLHQ VWNGTVPEGS KPGTYVMTVT AIDADDPNAL
       310        320        330        340        350        360
NGMLRYRIVS QAPSTPSPNM FTINNETGDI ITVAAGLDRE KVQQYTLIIQ ATDMEGNPTY
       370        380        390        400        410        420
GLSNTATAVI TVTDVNDNPP EFTAMTFYGE VPENRVDIIV ANLTVTDKDQ PHTPAWNAVY
       430        440        450        460        470        480
RISGGDPTGR FAIQTDPNSN DGLVTVVKPI DFETNRMFVL TVAAENQVPL AKGIQHPPQS
       490        500        510        520        530        540
TATVSVTVID VNENPYFAPN PKIIRQEEGL HAGTMLTTFT AQDPDRYMQQ NIRYTKLSDP
       550        560        570        580        590        600
ANWLKIDPVN GQITTIAVLD RESPNVKNNI YNATFLASDN GIPPMSGTGT LQIYLLDIND
       610        620        630        640        650        660
NAPQVLPQEA ETCETPDPNS INITALDYDI DPNAGPFAFD LPLSPVTIKR NWTITRLNGD
       670        680        690        700        710        720
FAQLNLKIKF LEAGIYEVPI IITDSGNPPK SNISILRVKV CQCDSNGDCT DVDRIVGAGL
       730        740        750        760        770        780
GTGAIIAILL CIIILLILVL MFVVWMKRRD KERQAKQLLI DPEDDVRDNI LKYDEEGGGE
       790        800        810        820        830        840
EDQDYDLSQL QQPDTVEPDA IKPVGIRRMD ERPIHAEPQY PVRSAAPHPG DIGDFINEGL
       850        860        870        880        890        900
KAADNDPTAP PYDSLLVFDY EGSGSTAGSL SSLNSSSSGG EQDYDYLNDW GPRFKKLADM

YGGGDD

Isoforms

- Isoform 2 of Cadherin-2

Sequence View

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

5 N-termini - 6 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P19022-26-unknown	SGEIAL...	26	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P19022-86-unknown	MVYAVR...	86	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000412120
P19022-86-unknown	MVYAVR...	86	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000414269
P19022-160-unknown	DWVIPP...	160	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P19022-160-unknown	DWVIPP...	160	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC16316
P19022-800-	AIKPVG...	800		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P19022-824-	SAAPHP...	824		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...LQRQKR	158	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000414269
...QRQKRD	159	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC16316
...GADQPP	205	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000412120
...HAVDIN	242	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000411360
...GGGDD	906	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...GGGDD	906		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...GGGDD	906		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
KLK4_HUMAN	159	QKRD.\|.DWVI	inferred from experiment	unknown	MEROPS	Nelson PS	Matsumura M et al.:Substrates of the prostate-spec... (S01.251)	15389820,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)