P20794: Serine/threonine-protein kinase MAK

General Information

Protein names	- Serine/threonine-protein kinase MAK - 2.7.11.1 {ECO:0000269\|PubMed:12084720, ECO:0000269\|PubMed:21986944} - Male germ cell-associated kinase
Gene names	MAK
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P20794

2 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Serine/threonine-protein kinase MAK - Isoform 3 of Serine/threonine-protein kinase MAK

Sequence View

        10         20         30         40         50         60
MNRYTTMRQL GDGTYGSVLM GKSNESGELV AIKRMKRKFY SWDECMNLRE VKSLKKLNHA
        70         80         90        100        110        120
NVIKLKEVIR ENDHLYFIFE YMKENLYQLM KDRNKLFPES VIRNIMYQIL QGLAFIHKHG
       130        140        150        160        170        180
FFHRDMKPEN LLCMGPELVK IADFGLAREL RSQPPYTDYV STRWYRAPEV LLRSSVYSSP
       190        200        210        220        230        240
IDVWAVGSIM AELYMLRPLF PGTSEVDEIF KICQVLGTPK KSDWPEGYQL ASSMNFRFPQ
       250        260        270        280        290        300
CVPINLKTLI PNASNEAIQL MTEMLNWDPK KRPTASQALK HPYFQVGQVL GPSSNHLESK
       310        320        330        340        350        360
QSLNKQLQPL ESKPSLVEVE PKPLPDIIDQ VVGQPQPKTS QQPLQPIQPP QNLSVQQPPK
       370        380        390        400        410        420
QQSQEKPPQT LFPSIVKNMP TKPNGTLSHK SGRRRWGQTI FKSGDSWEEL EDYDFGASHS
       430        440        450        460        470        480
KKPSMGVFKE KRKKDSPFRL PEPVPSGSNH STGENKSLPA VTSLKSDSEL STAPTSKQYY
       490        500        510        520        530        540
LKQSRYLPGV NPKKVSLIAS GKEINPHTWS NQLFPKSLGP VGAELAFKRS NAGNLGSYAT
       550        560        570        580        590        600
YNQSGYIPSF LKKEVQSAGQ RIHLAPLNAT ASEYTWNTKT GRGQFSGRTY NPTAKNLNIV
       610        620
NRAQPIPSVH GRTDWVAKYG GHR         10         20         30         40         50         60
MNRYTTMRQL GDGTYGSVLM GKSNESGELV AIKRMKRKFY SWDECMNLRE VKSLKKLNHA
        70         80         90        100        110        120
NVIKLKEVIR ENDHLYFIFE YMKENLYQLM KDRNKLFPES VIRNIMYQIL QGLAFIHKHG
       130        140        150        160        170        180
FFHRDMKPEN LLCMGPELVK IADFGLAREL RSQPPYTDYV STRWYRAPEV LLRSSVYSSP
       190        200        210        220        230        240
IDVWAVGSIM AELYMLRPLF PGTSEVDEIF KICQVLGTPK KSDWPEGYQL ASSMNFRFPQ
       250        260        270        280        290        300
CVPINLKTLI PNASNEAIQL MTEMLNWDPK KRPTASQALK HPYFQVGQVL GPSSNHLESK
       310        320        330        340        350        360
QSLNKQLQPL ESKPSLVEVE PKPLPDIIDQ VVGQPQPKTS QQPLQPIQPP QNLSVQQPPK
       370        380        390        400        410        420
QQSQEKPPQT LFPSIVKNMP TKPNGTLSHK SGRRRWGQTI FKSGDSWEEL EDYDFGASHS
       430        440        450        460        470        480
KKPSMGVFKE KRKKDSPFRL PEPVPSGSNH STGENKSLPA VTSLKSDSEL STAPTSKQYY
       490        500        510        520        530        540
LKQSRYLPGV NPKKVSLIAS GKEINPHTWS NQLFPKSLGP VGAELAFKRS NAGNLGSYAT
       550        560        570        580        590        600
YNQSGYIPSF LKKEVQSAGQ RIHLAPLNAT ASEYTWNTKT GRGQFSGRTY NPTAKNLNIV
       610        620
NRAQPIPSVH GRTDWVAKYG GHR

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

2 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P20794-1-unknown	MNRYTT...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P20794-1-unknown	MNRYTT...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt80336
P20794-1-unknown	MNRYTT...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt80337
P20794-30-unknown	VAIKRM...	30	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11326
P20794-30-unknown	VAIKRM...	30	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt137523
P20794-30-unknown	VAIKRM...	30	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt137526

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...ESGELV	29	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11326
...ESGELV	29	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt120502
...ESGELV	29	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt120505
...YGGHR	623	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...YGGHR	623	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt75955
...YGGHR	623	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt75954

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	29	GELV.\|.VAIK	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)