P21180: Complement C2

General Information

Protein names	- Complement C2 - 3.4.21.43 - C3/C5 convertase - Complement C2b fragment - Complement C2a fragment
Gene names	C2
Organism	Mus musculus
Protease Family	S01.194
Protease ID	S01.194
Chromosome location
UniProt ID	P21180

3 N-termini

2 C-termini

0 Cleavages

1 Substrates

Sequence

        10         20         30         40         50         60
MAPLLALFYL LQLGPGLAAL FCNQNVNITG GNFTLSHGWA PGSLLIYSCP LGRYPSPAWR
        70         80         90        100        110        120
KCQSNGQWLT PRSSSHHTLR SSRMVKAVCK PVRCLAPSSF ENGIYFPRLV SYPVGSNVSF
       130        140        150        160        170        180
ECEQDFTLRG SPVRYCRPNG LWDGETAVCD NGASHCPNPG ISVGTARTGL NFDLGDKVRY
       190        200        210        220        230        240
RCSSSNMVLT GSAERECQSN GVWSGSEPIC RQPYSYDFPE DVASALDTSL TNLLGATNPT
       250        260        270        280        290        300
QNLLTKSLGR KIIIQRSGHL NLYLLLDASQ SVTEKDFDIF KKSAELMVER IFSFEVNVSV
       310        320        330        340        350        360
AIITFASQPK TIMSILSERS QDVTEVITSL DSASYKDHEN ATGTNTYEVL IRVYSMMQSQ
       370        380        390        400        410        420
MDRLGMETSA WKEIRHTIIL LTDGKSNMGD SPKKAVTRIR ELLSIEQNRD DYLDIYAIGV
       430        440        450        460        470        480
GKLDVDWKEL NELGSKKDGE RHAFILQDAK ALQQIFEHML DVSKLTDTIC GVGNMSANAS
       490        500        510        520        530        540
DQERTPWQVT FKPKSKETCQ GSLISDQWVL TAAHCFHDIQ MEDHHLWRVN VGDPTSQHGK
       550        560        570        580        590        600
EFLVEDVIIA PGFNVHAKRK QGISEFYADD IALLKLSRKV KMSTHARPIC LPCTVGANMA
       610        620        630        640        650        660
LRRSPGSTCK DHETELLSQQ KVPAHFVALN GNRLNINLRT GPEWTRCIQA VSQNKNIFPS
       670        680        690        700        710        720
LTNVSEVVTD QFLCSGMEEE DDNPCKGESG GAVFLGRRYR FFQVGLVSWG LFDPCHGSSN
       730        740        750        760
KNLRKKPPRG VLPRDFHISL FRLQPWLRQH LDGVLDFLPL

Isoforms

- Isoform Short of Complement C2

Sequence View

        10         20         30         40         50         60
MAPLLALFYL LQLGPGLAAL FCNQNVNITG GNFTLSHGWA PGSLLIYSCP LGRYPSPAWR
        70         80         90        100        110        120
KCQSNGQWLT PRSSSHHTLR SSRMVKAVCK PVRCLAPSSF ENGIYFPRLV SYPVGSNVSF
       130        140        150        160        170        180
ECEQDFTLRG SPVRYCRPNG LWDGETAVCD NGASHCPNPG ISVGTARTGL NFDLGDKVRY
       190        200        210        220        230        240
RCSSSNMVLT GSAERECQSN GVWSGSEPIC RQPYSYDFPE DVASALDTSL TNLLGATNPT
       250        260        270        280        290        300
QNLLTKSLGR KIIIQRSGHL NLYLLLDASQ SVTEKDFDIF KKSAELMVER IFSFEVNVSV
       310        320        330        340        350        360
AIITFASQPK TIMSILSERS QDVTEVITSL DSASYKDHEN ATGTNTYEVL IRVYSMMQSQ
       370        380        390        400        410        420
MDRLGMETSA WKEIRHTIIL LTDGKSNMGD SPKKAVTRIR ELLSIEQNRD DYLDIYAIGV
       430        440        450        460        470        480
GKLDVDWKEL NELGSKKDGE RHAFILQDAK ALQQIFEHML DVSKLTDTIC GVGNMSANAS
       490        500        510        520        530        540
DQERTPWQVT FKPKSKETCQ GSLISDQWVL TAAHCFHDIQ MEDHHLWRVN VGDPTSQHGK
       550        560        570        580        590        600
EFLVEDVIIA PGFNVHAKRK QGISEFYADD IALLKLSRKV KMSTHARPIC LPCTVGANMA
       610        620        630        640        650        660
LRRSPGSTCK DHETELLSQQ KVPAHFVALN GNRLNINLRT GPEWTRCIQA VSQNKNIFPS
       670        680        690        700        710        720
LTNVSEVVTD QFLCSGMEEE DDNPCKGESG GAVFLGRRYR FFQVGLVSWG LFDPCHGSSN
       730        740        750        760
KNLRKKPPRG VLPRDFHISL FRLQPWLRQH LDGVLDFLPL

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P21180-1-unknown	MAPLLA...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt71268
P21180-19-unknown	ALFCNQ...	19	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P21180-19-unknown	ALFCNQ...	19	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt112216
P21180-251-unknown	KIIIQR...	251	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P21180-251-unknown	KIIIQR...	251	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt116096

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...KSLGRK	250	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...KSLGRK	250	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt92095
...DFLPL	760	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...DFLPL	760	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt66886

TopFIND

P21180: Complement C2

General Information

3

N-termini

2

C-termini

0

Cleavages

1

Substrates

Sequence

Isoforms

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Protein Neighborhood

Domains & Features

3 N-termini - 2 C-termini - 0 Cleavages - 1 Substrates

N-termini

C-termini

Cleavages

Substrates