P01027: Complement C3

General Information

Protein names	- Complement C3 - HSE-MSF - Complement C3 beta chain - C3-beta-c - C3bc - Complement C3 alpha chain - C3a anaphylatoxin - Acylation stimulating protein - ASP - C3adesArg - Complement C3b alpha' chain - Complement C3c alpha' chain fragment 1 - Complement C3dg fragment - Complement C3g fragment - Complement C3d fragment - Complement C3f fragment - Complement C3c alpha' chain fragment 2
Gene names	C3
Organism	Mus musculus
Protease Family
Protease ID	I39.950
Chromosome location
UniProt ID	P01027

26 N-termini

8 C-termini

3 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MGPASGSQLL VLLLLLASSP LALGIPMYSI ITPNVLRLES EETIVLEAHD AQGDIPVTVT
        70         80         90        100        110        120
VQDFLKRQVL TSEKTVLTGA SGHLRSVSIK IPASKEFNSD KEGHKYVTVV ANFGETVVEK
       130        140        150        160        170        180
AVMVSFQSGY LFIQTDKTIY TPGSTVLYRI FTVDNNLLPV GKTVVILIET PDGIPVKRDI
       190        200        210        220        230        240
LSSNNQHGIL PLSWNIPELV NMGQWKIRAF YEHAPKQIFS AEFEVKEYVL PSFEVRVEPT
       250        260        270        280        290        300
ETFYYIDDPN GLEVSIIAKF LYGKNVDGTA FVIFGVQDGD KKISLAHSLT RVVIEDGVGD
       310        320        330        340        350        360
AVLTRKVLME GVRPSNADAL VGKSLYVSVT VILHSGSDMV EAERSGIPIV TSPYQIHFTK
       370        380        390        400        410        420
TPKFFKPAMP FDLMVFVTNP DGSPASKVLV VTQGSNAKAL TQDDGVAKLS INTPNSRQPL
       430        440        450        460        470        480
TITVRTKKDT LPESRQATKT MEAHPYSTMH NSNNYLHLSV SRMELKPGDN LNVNFHLRTD
       490        500        510        520        530        540
PGHEAKIRYY TYLVMNKGKL LKAGRQVREP GQDLVVLSLP ITPEFIPSFR LVAYYTLIGA
       550        560        570        580        590        600
SGQREVVADS VWVDVKDSCI GTLVVKGDPR DNHLAPGQQT TLRIEGNQGA RVGLVAVDKG
       610        620        630        640        650        660
VFVLNKKNKL TQSKIWDVVE KADIGCTPGS GKNYAGVFMD AGLAFKTSQG LQTEQRADLE
       670        680        690        700        710        720
CTKPAARRRR SVQLMERRMD KAGQYTDKGL RKCCEDGMRD IPMRYSCQRR ARLITQGENC
       730        740        750        760        770        780
IKAFIDCCNH ITKLREQHRR DHVLGLARSE LEEDIIPEED IISRSHFPQS WLWTIEELKE
       790        800        810        820        830        840
PEKNGISTKV MNIFLKDSIT TWEILAVSLS DKKGICVADP YEIRVMQDFF IDLRLPYSVV
       850        860        870        880        890        900
RNEQVEIRAV LFNYREQEEL KVRVELLHNP AFCSMATAKN RYFQTIKIPP KSSVAVPYVI
       910        920        930        940        950        960
VPLKIGQQEV EVKAAVFNHF ISDGVKKTLK VVPEGMRINK TVAIHTLDPE KLGQGGVQKV
       970        980        990       1000       1010       1020
DVPAADLSDQ VPDTDSETRI ILQGSPVVQM AEDAVDGERL KHLIVTPAGC GEQNMIGMTP
      1030       1040       1050       1060       1070       1080
TVIAVHYLDQ TEQWEKFGIE KRQEALELIK KGYTQQLAFK QPSSAYAAFN NRPPSTWLTA
      1090       1100       1110       1120       1130       1140
YVVKVFSLAA NLIAIDSHVL CGAVKWLILE KQKPDGVFQE DGPVIHQEMI GGFRNAKEAD
      1150       1160       1170       1180       1190       1200
VSLTAFVLIA LQEARDICEG QVNSLPGSIN KAGEYIEASY MNLQRPYTVA IAGYALALMN
      1210       1220       1230       1240       1250       1260
KLEEPYLGKF LNTAKDRNRW EEPDQQLYNV EATSYALLAL LLLKDFDSVP PVVRWLNEQR
      1270       1280       1290       1300       1310       1320
YYGGGYGSTQ ATFMVFQALA QYQTDVPDHK DLNMDVSFHL PSRSSATTFR LLWENGNLLR
      1330       1340       1350       1360       1370       1380
SEETKQNEAF SLTAKGKGRG TLSVVAVYHA KLKSKVTCKK FDLRVSIRPA PETAKKPEEA
      1390       1400       1410       1420       1430       1440
KNTMFLEICT KYLGDVDATM SILDISMMTG FAPDTKDLEL LASGVDRYIS KYEMNKAFSN
      1450       1460       1470       1480       1490       1500
KNTLIIYLEK ISHTEEDCLT FKVHQYFNVG LIQPGSVKVY SYYNLEESCT RFYHPEKDDG
      1510       1520       1530       1540       1550       1560
MLSKLCHSEM CRCAEENCFM QQSQEKINLN VRLDKACEPG VDYVYKTELT NIELLDDFDE
      1570       1580       1590       1600       1610       1620
YTMTIQQVIK SGSDEVQAGQ QRKFISHIKC RNALKLQKGK KYLMWGLSSD LWGEKPNTSY
      1630       1640       1650       1660
IIGKDTWVEH WPEAEECQDQ KYQKQCEELG AFTESMVVYG CPN

Isoforms

- Isoform Short of Complement C3

Sequence View

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

26 N-termini - 8 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Evidence name	Publications (PMID)
P01027-24-unmodified	GIPMYS...	24			unknown		Kleifeldt O. et al.: N-terminome analysis of bronchoalveolar lavage fluids collected from...	20208520
P01027-25-unknown	IPMYSI...	25		inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P01027-25-unmodified	IPMYSI...	25			unknown		Kleifeldt O. et al.: N-terminome analysis of bronchoalveolar lavage fluids collected from...	20208520
P01027-68-Pyrrolidone carboxylic acid	QVLTSE...	68	pyrrolidone carboxylic acid-		unknown		Kleifeldt O. et al.: N-terminome analysis of bronchoalveolar lavage fluids collected from...	20208520
P01027-71-unmodified	TSEKTV...	71			unknown		Kleifeldt O. et al.: N-terminome analysis of bronchoalveolar lavage fluids collected from...	20208520
P01027-75-unmodified	TVLTGA...	75			unknown		Kleifeldt O. et al.: N-terminome analysis of bronchoalveolar lavage fluids collected from...	20208520
P01027-138-unmodified	TIYTPG...	138			unknown		Kleifeldt O. et al.: N-terminome analysis of bronchoalveolar lavage fluids collected from...	20208520
P01027-163-unmodified	TVVILI...	163			unknown		Kleifeldt O. et al.: N-terminome analysis of bronchoalveolar lavage fluids collected from...	20208520
P01027-337-unmodified	SDMVEA...	337			unknown		Kleifeldt O. et al.: N-terminome analysis of bronchoalveolar lavage fluids collected from...	20208520
P01027-452-unmodified	SNNYLH...	452			unknown		Kleifeldt O. et al.: N-terminome analysis of bronchoalveolar lavage fluids collected from...	20208520
P01027-671-unknown	SVQLME...	671		inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P01027-679-unmodified	MDKAGQ...	679			unknown		Kleifeldt O. et al.: N-terminome analysis of bronchoalveolar lavage fluids collected from...	20208520
P01027-749-unknown	SELEED...	749		inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)
P01027-749-unknown	SELEED...	749		inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P01027-749-unknown	SELEED...	749		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31573
P01027-749-unmodified	SELEED...	749			unknown		Kleifeldt O. et al.: N-terminome analysis of bronchoalveolar lavage fluids collected from...	20208520
P01027-751-unmodified	LEEDII...	751			unknown		Kleifeldt O. et al.: N-terminome analysis of bronchoalveolar lavage fluids collected from...	20208520
P01027-955-unknown	GGVQKV...	955		inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P01027-960-unmodified	VDVPAA...	960			unknown		Kleifeldt O. et al.: N-terminome analysis of bronchoalveolar lavage fluids collected from...	20208520
P01027-961-unmodified	DVPAAD...	961			unknown		Kleifeldt O. et al.: N-terminome analysis of bronchoalveolar lavage fluids collected from...	20208520
P01027-1002-unknown	HLIVTP...	1002		inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P01027-1043-Pyrrolidone carboxylic acid	QEALEL...	1043	pyrrolidone carboxylic acid-		unknown		Kleifeldt O. et al.: N-terminome analysis of bronchoalveolar lavage fluids collected from...	20208520
P01027-1129-unknown	MIGGFR...	1129		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt71270
P01027-1304-unknown	SSATTF...	1304		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31500
P01027-1304-unknown	SSATTF...	1304		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt145720
P01027-1321-unknown	SEETKQ...	1321		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31502
P01027-1321-unknown	SEETKQ...	1321		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt116485
P01027-1321-unknown	SEETKQ...	1321		inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P01027-1321-unmodified	SEETKQ...	1321			unknown		Kleifeldt O. et al.: N-terminome analysis of bronchoalveolar lavage fluids collected from...	20208520
P01027-1409-unknown	TGFAPD...	1409		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt161097
P01027-1409-unmodified	TGFAPD...	1409			unknown		Kleifeldt O. et al.: N-terminome analysis of bronchoalveolar lavage fluids collected from...	20208520

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...TKPAAR	666	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...VLGLAR	747	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...LGLARS	748	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...LGLARS	748	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31573
...EKLGQG	954	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...GERLKH	1001	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...HLPSRS	1303	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...HLPSRS	1303	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31500
...HLPSRS	1303	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt93727
...GNLLRS	1320	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31502
...GNLLRS	1320	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129634
...YGCPN	1663	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...YGCPN	1663	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt66888

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Evidence name
CO2_MOUSE	748	LARS.\|.SELE	inferred from experiment	unknown	MEROPS	Merops CO2_MOUSE -> CO3_MOUSE @748
CFAI_MOUSE	1303	PSRS.\|.SSAT	inferred from experiment	unknown	MEROPS	Merops CFAI_MOUSE -> CO3_MOUSE @1303
CFAI_MOUSE	1320	LLRS.\|.SEET	inferred from experiment	unknown	MEROPS	Merops CFAI_MOUSE -> CO3_MOUSE @1320

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)