P21580: Tumor necrosis factor alpha-induced protein 3

General Information

Protein names	- Tumor necrosis factor alpha-induced protein 3 - TNF alpha-induced protein 3 - 2.3.2.- - 3.4.19.12 {ECO:0000269\|PubMed:14748687, ECO:0000269\|PubMed:17961127, ECO:0000269\|PubMed:18164316, ECO:0000269\|PubMed:23827681, ECO:0000269\|PubMed:27732584} - OTU domain-containing protein 7C - Putative DNA-binding protein A20 - Zinc finger protein A20 - A20p50 - A20p37
Gene names	TNFAIP3
Organism	Homo sapiens
Protease Family
Protease ID	C64.003
Chromosome location
UniProt ID	P21580

3 N-termini

5 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAEQVLPQAL YLSNMRKAVK IRERTPEDIF KPTNGIIHHF KTMHRYTLEM FRTCQFCPQF
        70         80         90        100        110        120
REIIHKALID RNIQATLESQ KKLNWCREVR KLVALKTNGD GNCLMHATSQ YMWGVQDTDL
       130        140        150        160        170        180
VLRKALFSTL KETDTRNFKF RWQLESLKSQ EFVETGLCYD TRNWNDEWDN LIKMASTDTP
       190        200        210        220        230        240
MARSGLQYNS LEEIHIFVLC NILRRPIIVI SDKMLRSLES GSNFAPLKVG GIYLPLHWPA
       250        260        270        280        290        300
QECYRYPIVL GYDSHHFVPL VTLKDSGPEI RAVPLVNRDR GRFEDLKVHF LTDPENEMKE
       310        320        330        340        350        360
KLLKEYLMVI EIPVQGWDHG TTHLINAAKL DEANLPKEIN LVDDYFELVQ HEYKKWQENS
       370        380        390        400        410        420
EQGRREGHAQ NPMEPSVPQL SLMDVKCETP NCPFFMSVNT QPLCHECSER RQKNQNKLPK
       430        440        450        460        470        480
LNSKPGPEGL PGMALGASRG EAYEPLAWNP EESTGGPHSA PPTAPSPFLF SETTAMKCRS
       490        500        510        520        530        540
PGCPFTLNVQ HNGFCERCHN ARQLHASHAP DHTRHLDPGK CQACLQDVTR TFNGICSTCF
       550        560        570        580        590        600
KRTTAEASSS LSTSLPPSCH QRSKSDPSRL VRSPSPHSCH RAGNDAPAGC LSQAARTPGD
       610        620        630        640        650        660
RTGTSKCRKA GCVYFGTPEN KGFCTLCFIE YRENKHFAAA SGKVSPTASR FQNTIPCLGR
       670        680        690        700        710        720
ECGTLGSTMF EGYCQKCFIE AQNQRFHEAK RTEEQLRSSQ RRDVPRTTQS TSRPKCARAS
       730        740        750        760        770        780
CKNILACRSE ELCMECQHPN QRMGPGAHRG EPAPEDPPKQ RCRAPACDHF GNAKCNGYCN
       790
ECFQFKQMYG

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

3 N-termini - 5 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P21580-2-unknown	MAEQVL...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P21580-2-Acetylation	AEQVLP...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P21580-2-Acetylation	AEQVLP...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P21580-2-Acetylation	AEQVLP...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P21580-440-unknown	GEAYEP...	440		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P21580-440-unknown	GEAYEP...	440		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC16778

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...IRERTP	25	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000393577
...ALKTNG	98	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000409845
...CYDTRN	162	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000401562
...LGASRG	439	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...LGASRG	439	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16778
...KQMYG	790	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MALT1_HUMAN	439	ASRG.\|.GEAY	inferred from experiment	unknown	MEROPS	Beyaert R	Coornaert B et al.:T cell antigen receptor stimula... (C14.026)	18223652,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)