P22695: Cytochrome b-c1 complex subunit 2, mitochondrial

General Information

Protein names	- Cytochrome b-c1 complex subunit 2, mitochondrial - Complex III subunit 2 - Core protein II - Ubiquinol-cytochrome-c reductase complex core protein 2
Gene names	UQCRC2
Organism	Homo sapiens
Protease Family
Protease ID	M16.974
Chromosome location
UniProt ID	P22695

4 N-termini

2 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MKLLTRAGSF SRFYSLKVAP KVKATAAPAG APPQPQDLEF TKLPNGLVIA SLENYSPVSR
        70         80         90        100        110        120
IGLFIKAGSR YEDFSNLGTT HLLRLTSSLT TKGASSFKIT RGIEAVGGKL SVTATRENMA
       130        140        150        160        170        180
YTVECLRGDV DILMEFLLNV TTAPEFRRWE VADLQPQLKI DKAVAFQNPQ THVIENLHAA
       190        200        210        220        230        240
AYRNALANPL YCPDYRIGKV TSEELHYFVQ NHFTSARMAL IGLGVSHPVL KQVAEQFLNM
       250        260        270        280        290        300
RGGLGLSGAK ANYRGGEIRE QNGDSLVHAA FVAESAVAGS AEANAFSVLQ HVLGAGPHVK
       310        320        330        340        350        360
RGSNTTSHLH QAVAKATQQP FDVSAFNASY SDSGLFGIYT ISQATAAGDV IKAAYNQVKT
       370        380        390        400        410        420
IAQGNLSNTD VQAAKNKLKA GYLMSVESSE CFLEEVGSQA LVAGSYMPPS TVLQQIDSVA
       430        440        450
NADIINAAKK FVSGQKSMAA SGNLGHTPFV DEL

Isoforms

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 2 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P22695-15-unknown	SLKVAP...	15	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P22695-15-unknown	SLKVAP...	15		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P22695-15-	SLKVAP...	15		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P22695-15-	SLKVAP...	15		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P22695-15-	SLKVAP...	15		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P22695-15-	SLKVAP...	15		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P22695-22-	VKATAA...	22		Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
P22695-271-	FVAESA...	271		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P22695-271-	FVAESA...	271		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P22695-271-	FVAESA...	271		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P22695-271-	FVAESA...	271		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...VTSEEL	204	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000455088
	...FVDEL	453	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)