P23921: Ribonucleoside-diphosphate reductase large subunit

General Information

Protein names	- Ribonucleoside-diphosphate reductase large subunit - 1.17.4.1 - Ribonucleoside-diphosphate reductase subunit M1 - Ribonucleotide reductase large subunit
Gene names	RRM1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P23921

5 N-termini

3 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MHVIKRDGRQ ERVMFDKITS RIQKLCYGLN MDFVDPAQIT MKVIQGLYSG VTTVELDTLA
        70         80         90        100        110        120
AETAATLTTK HPDYAILAAR IAVSNLHKET KKVFSDVMED LYNYINPHNG KHSPMVAKST
       130        140        150        160        170        180
LDIVLANKDR LNSAIIYDRD FSYNYFGFKT LERSYLLKIN GKVAERPQHM LMRVSVGIHK
       190        200        210        220        230        240
EDIDAAIETY NLLSERWFTH ASPTLFNAGT NRPQLSSCFL LSMKDDSIEG IYDTLKQCAL
       250        260        270        280        290        300
ISKSAGGIGV AVSCIRATGS YIAGTNGNSN GLVPMLRVYN NTARYVDQGG NKRPGAFAIY
       310        320        330        340        350        360
LEPWHLDIFE FLDLKKNTGK EEQRARDLFF ALWIPDLFMK RVETNQDWSL MCPNECPGLD
       370        380        390        400        410        420
EVWGEEFEKL YASYEKQGRV RKVVKAQQLW YAIIESQTET GTPYMLYKDS CNRKSNQQNL
       430        440        450        460        470        480
GTIKCSNLCT EIVEYTSKDE VAVCNLASLA LNMYVTSEHT YDFKKLAEVT KVVVRNLNKI
       490        500        510        520        530        540
IDINYYPVPE ACLSNKRHRP IGIGVQGLAD AFILMRYPFE SAEAQLLNKQ IFETIYYGAL
       550        560        570        580        590        600
EASCDLAKEQ GPYETYEGSP VSKGILQYDM WNVTPTDLWD WKVLKEKIAK YGIRNSLLIA
       610        620        630        640        650        660
PMPTASTAQI LGNNESIEPY TSNIYTRRVL SGEFQIVNPH LLKDLTERGL WHEEMKNQII
       670        680        690        700        710        720
ACNGSIQSIP EIPDDLKQLY KTVWEISQKT VLKMAAERGA FIDQSQSLNI HIAEPNYGKL
       730        740        750        760        770        780
TSMHFYGWKQ GLKTGMYYLR TRPAANPIQF TLNKEKLKDK EKVSKEEEEK ERNTAAMVCS
       790
LENRDECLMC GS

Isoforms

Sequence View

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Physiological Relevance:

Evidence Codes:

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Evidence Names:

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Protein Neighborhood

Domains & Features

5 N-termini - 3 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P23921-1-unknown	MHVIKR...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P23921-98-unknown	MEDLYN...	98	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000390539
P23921-223-unknown	MKDDSI...	223	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000431464
P23921-339-unknown	MKRVET...	339	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000442148
P23921-635-unknown	QIVNPH...	635	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17525

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...LSGEFQ	634	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17525
...LMCGS	792		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...LMCGS	792		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...LMCGS	792	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...LMCGS	792		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...LMCGS	792		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1A_HUMAN	634	GEFQ.\|.QIVN	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)