P25685: DnaJ homolog subfamily B member 1

General Information

Protein names	- DnaJ homolog subfamily B member 1 - DnaJ protein homolog 1 - Heat shock 40 kDa protein 1 - HSP40 - Heat shock protein 40 - Human DnaJ protein 1 - hDj-1
Gene names	DNAJB1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P25685

6 N-termini

9 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MGKDYYQTLG LARGASDEEI KRAYRRQALR YHPDKNKEPG AEEKFKEIAE AYDVLSDPRK
        70         80         90        100        110        120
REIFDRYGEE GLKGSGPSGG SGGGANGTSF SYTFHGDPHA MFAEFFGGRN PFDTFFGQRN
       130        140        150        160        170        180
GEEGMDIDDP FSGFPMGMGG FTNVNFGRSR SAQEPARKKQ DPPVTHDLRV SLEEIYSGCT
       190        200        210        220        230        240
KKMKISHKRL NPDGKSIRNE DKILTIEVKK GWKEGTKITF PKEGDQTSNN IPADIVFVLK
       250        260        270        280        290        300
DKPHNIFKRD GSDVIYPARI SLREALCGCT VNVPTLDGRT IPVVFKDVIR PGMRRKVPGE
       310        320        330        340
GLPLPKTPEK RGDLIIEFEV IFPERIPQTS RTVLEQVLPI

Isoforms

- Isoform 2 of DnaJ homolog subfamily B member 1

Sequence View

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Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

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Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

6 N-termini - 9 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P25685-2-	GKDYYQ...	2		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P25685-2-	GKDYYQ...	2		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P25685-2-	GKDYYQ...	2		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P25685-2-	GKDYYQ...	2		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P25685-2-unknown	GKDYYQ...	2	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P25685-2-unknown	GKDYYQ...	2		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P25685-2-unknown	GKDYYQ...	2		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P25685-2-unknown	GKDYYQ...	2		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P25685-101-unknown	MFAEFF...	101	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000444212
P25685-101-unknown	MFAEFF...	101	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000471073
P25685-101-unknown	MFAEFF...	101	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000470063
P25685-101-unknown	MFAEFF...	101	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000470596
P25685-101-unknown	MFAEFF...	101	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000470460
P25685-101-unknown	MFAEFF...	101	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000471798
P25685-101-unknown	MFAEFF...	101	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000472886
P25685-101-unknown	MFAEFF...	101	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000471603
P25685-137-	GMGGFT...	137		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P25685-137-unknown	GMGGFT...	137		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P25685-151-	SAQEPA...	151		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...IYSGCT	179	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000471603
...YSGCTK	180	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000472886
...HKRLNP	191	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000471798
...ILTIEV	207	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000470460
...WKEGTK	216	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000470063
...WKEGTK	216	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000470596
...DQTSNN	229	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000469221
...RTIPVV	283	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000471073
...QVLPI	340		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...QVLPI	340		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...QVLPI	340	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...QVLPI	340		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...QVLPI	340		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)