P25787: Proteasome subunit alpha type-2

General Information

Protein names	- Proteasome subunit alpha type-2 - 3.4.25.1 {ECO:0000269\|PubMed:27176742} - Macropain subunit C3 - Multicatalytic endopeptidase complex subunit C3 - Proteasome component C3
Gene names	PSMA2
Organism	Homo sapiens
Protease Family
Protease ID	T01.972
Chromosome location
UniProt ID	P25787

7 N-termini

3 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAERGYSFSL TTFSPSGKLV QIEYALAAVA GGAPSVGIKA ANGVVLATEK KQKSILYDER
        70         80         90        100        110        120
SVHKVEPITK HIGLVYSGMG PDYRVLVHRA RKLAQQYYLV YQEPIPTAQL VQRVASVMQE
       130        140        150        160        170        180
YTQSGGVRPF GVSLLICGWN EGRPYLFQSD PSGAYFAWKA TAMGKNYVNG KTFLEKRYNE
       190        200        210        220        230
DLELEDAIHT AILTLKESFE GQMTEDNIEV GICNEAGFRR LTPTEVKDYL AAIA

Isoforms

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

7 N-termini - 3 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P25787-2-unknown	MAERGY...	1		inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
P25787-2-unknown	MAERGY...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P25787-2-Acetylation	AERGYS...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P25787-2-Acetylation	AERGYS...	2	acetylation-	inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
P25787-28-	AVAGGA...	28			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P25787-43-	GVVLAT...	43			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P25787-73-	GLVYSG...	73			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
P25787-73-	GLVYSG...	73			Subtiligase Based Positive Selection		Wells	apopotic_Jurkat_FasL	23264352
P25787-73-unknown	GLVYSG...	73			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P25787-79-unknown	MGPDYR...	79		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000440009

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...FLEKRY	177	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000440009
...LAAIA	234	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...LAAIA	234		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...LAAIA	234		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...LAAIA	234		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...LAAIA	234		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)