P27144: Adenylate kinase 4, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03170}

General Information

Protein names	- Adenylate kinase 4, mitochondrial {ECO:0000255\|HAMAP-Rule:MF_03170} - AK 4 {ECO:0000255\|HAMAP-Rule:MF_03170} - 2.7.4.10 {ECO:0000255\|HAMAP-Rule:MF_03170} - 2.7.4.6 {ECO:0000255\|HAMAP-Rule:MF_03170} - Adenylate kinase 3-like {ECO:0000255\|HAMAP-Rule:MF_03170} - GTP:AMP phosphotransferase AK4 {ECO:0000255\|HAMAP-Rule:MF_03170}
Gene names	AK4
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P27144

4 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MASKLLRAVI LGPPGSGKGT VCQRIAQNFG LQHLSSGHFL RENIKASTEV GEMAKQYIEK
        70         80         90        100        110        120
SLLVPDHVIT RLMMSELENR RGQHWLLDGF PRTLGQAEAL DKICEVDLVI SLNIPFETLK
       130        140        150        160        170        180
DRLSRRWIHP PSGRVYNLDF NPPHVHGIDD VTGEPLVQQE DDKPEAVAAR LRQYKDVAKP
       190        200        210        220
VIELYKSRGV LHQFSGTETN KIWPYVYTLF SNKITPIQSK EAY

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

4 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P27144-1-unknown	MASKLL...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P27144-2-acetylation	ASKLLR...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P27144-2-acetylation	ASKLLR...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P27144-53-unknown	MAKQYI...	53		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000448458
P27144-192-unknown	HQFSGT...	192		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7392

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...SRGVLH	191	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7392
	...SKEAY	223	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATS_HUMAN	191	GVLH.\|.HQFS	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)