TopFIND 4.0

P29973: cGMP-gated cation channel alpha-1

General Information

Protein names
- cGMP-gated cation channel alpha-1
- Cyclic nucleotide-gated cation channel 1
- Cyclic nucleotide-gated channel alpha-1
- CNG channel alpha-1
- CNG-1
- CNG1
- Cyclic nucleotide-gated channel, photoreceptor
- Rod photoreceptor cGMP-gated channel subunit alpha
Gene names CNGA1
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID P29973

2

N-termini

2

C-termini

1

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MKLSMKNNII NTQQSFVTMP NVIVPDIEKE IRRMENGACS SFSEDDDSAS TSEESENENP 
        70         80         90        100        110        120 
HARGSFSYKS LRKGGPSQRE QYLPGAIALF NVNNSSNKDQ EPEEKKKKKK EKKSKSDDKN 
       130        140        150        160        170        180 
ENKNDPEKKK KKKDKEKKKK EEKSKDKKEE EKKEVVVIDP SGNTYYNWLF CITLPVMYNW 
       190        200        210        220        230        240 
TMVIARACFD ELQSDYLEYW LILDYVSDIV YLIDMFVRTR TGYLEQGLLV KEELKLINKY 
       250        260        270        280        290        300 
KSNLQFKLDV LSLIPTDLLY FKLGWNYPEI RLNRLLRFSR MFEFFQRTET RTNYPNIFRI 
       310        320        330        340        350        360 
SNLVMYIVII IHWNACVFYS ISKAIGFGND TWVYPDINDP EFGRLARKYV YSLYWSTLTL 
       370        380        390        400        410        420 
TTIGETPPPV RDSEYVFVVV DFLIGVLIFA TIVGNIGSMI SNMNAARAEF QARIDAIKQY 
       430        440        450        460        470        480 
MHFRNVSKDM EKRVIKWFDY LWTNKKTVDE KEVLKYLPDK LRAEIAINVH LDTLKKVRIF 
       490        500        510        520        530        540 
ADCEAGLLVE LVLKLQPQVY SPGDYICKKG DIGREMYIIK EGKLAVVADD GVTQFVVLSD 
       550        560        570        580        590        600 
GSYFGEISIL NIKGSKAGNR RTANIKSIGY SDLFCLSKDD LMEALTEYPD AKTMLEEKGK 
       610        620        630        640        650        660 
QILMKDGLLD LNIANAGSDP KDLEEKVTRM EGSVDLLQTR FARILAEYES MQQKLKQRLT 
       670        680        690    
KVEKFLKPLI DTEFSSIEGP GAESGPIDST 

Isoforms

- Isoform 2 of cGMP-gated cation channel alpha-1

Sequence View

        10         20         30         40         50         60 
MKLSMKNNII NTQQSFVTMP NVIVPDIEKE IRRMENGACS SFSEDDDSAS TSEESENENP 
        70         80         90        100        110        120 
HARGSFSYKS LRKGGPSQRE QYLPGAIALF NVNNSSNKDQ EPEEKKKKKK EKKSKSDDKN 
       130        140        150        160        170        180 
ENKNDPEKKK KKKDKEKKKK EEKSKDKKEE EKKEVVVIDP SGNTYYNWLF CITLPVMYNW 
       190        200        210        220        230        240 
TMVIARACFD ELQSDYLEYW LILDYVSDIV YLIDMFVRTR TGYLEQGLLV KEELKLINKY 
       250        260        270        280        290        300 
KSNLQFKLDV LSLIPTDLLY FKLGWNYPEI RLNRLLRFSR MFEFFQRTET RTNYPNIFRI 
       310        320        330        340        350        360 
SNLVMYIVII IHWNACVFYS ISKAIGFGND TWVYPDINDP EFGRLARKYV YSLYWSTLTL 
       370        380        390        400        410        420 
TTIGETPPPV RDSEYVFVVV DFLIGVLIFA TIVGNIGSMI SNMNAARAEF QARIDAIKQY 
       430        440        450        460        470        480 
MHFRNVSKDM EKRVIKWFDY LWTNKKTVDE KEVLKYLPDK LRAEIAINVH LDTLKKVRIF 
       490        500        510        520        530        540 
ADCEAGLLVE LVLKLQPQVY SPGDYICKKG DIGREMYIIK EGKLAVVADD GVTQFVVLSD 
       550        560        570        580        590        600 
GSYFGEISIL NIKGSKAGNR RTANIKSIGY SDLFCLSKDD LMEALTEYPD AKTMLEEKGK 
       610        620        630        640        650        660 
QILMKDGLLD LNIANAGSDP KDLEEKVTRM EGSVDLLQTR FARILAEYES MQQKLKQRLT 
       670        680        690    
KVEKFLKPLI DTEFSSIEGP GAESGPIDST 



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Protein Neighborhood

Domains & Features

2 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

C-termini

Cleavages

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)