P30085: UMP-CMP kinase {ECO:0000255|HAMAP-Rule:MF_03172}

General Information

Protein names	- UMP-CMP kinase {ECO:0000255\|HAMAP-Rule:MF_03172} - 2.7.4.14 {ECO:0000255\|HAMAP-Rule:MF_03172} - Deoxycytidylate kinase {ECO:0000255\|HAMAP-Rule:MF_03172} - CK {ECO:0000255\|HAMAP-Rule:MF_03172} - dCMP kinase {ECO:0000255\|HAMAP-Rule:MF_03172} - Nucleoside-diphosphate kinase {ECO:0000255\|HAMAP-Rule:MF_03172} - 2.7.4.6 {ECO:0000255\|HAMAP-Rule:MF_03172} - Uridine monophosphate/cytidine monophosphate kinase {ECO:0000255\|HAMAP-Rule:MF_03172} - UMP/CMP kinase {ECO:0000255\|HAMAP-Rule:MF_03172} - UMP/CMPK {ECO:0000255\|HAMAP-Rule:MF_03172}
Gene names	CMPK1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P30085

2 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of UMP-CMP kinase - Isoform 3 of UMP-CMP kinase

Sequence View

        10         20         30         40         50         60
MKPLVVFVLG GPGAGKGTQC ARIVEKYGYT HLSAGELLRD ERKNPDSQYG ELIEKYIKEG
        70         80         90        100        110        120
KIVPVEITIS LLKREMDQTM AANAQKNKFL IDGFPRNQDN LQGWNKTMDG KADVSFVLFF
       130        140        150        160        170        180
DCNNEICIER CLERGKSSGR SDDNRESLEK RIQTYLQSTK PIIDLYEEMG KVKKIDASKS
       190
VDEVFDEVVQ IFDKEG         10         20         30         40         50         60
MKPLVVFVLG GPGAGKGTQC ARIVEKYGYT HLSAGELLRD ERKNPDSQYG ELIEKYIKEG
        70         80         90        100        110        120
KIVPVEITIS LLKREMDQTM AANAQKNKFL IDGFPRNQDN LQGWNKTMDG KADVSFVLFF
       130        140        150        160        170        180
DCNNEICIER CLERGKSSGR SDDNRESLEK RIQTYLQSTK PIIDLYEEMG KVKKIDASKS
       190
VDEVFDEVVQ IFDKEG

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Physiological Relevance:

Evidence Codes:

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Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

2 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P30085-1-unknown	MKPLVV...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P30085-1-unknown	MKPLVV...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt78844
P30085-1-unknown	MKPLVV...	1		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P30085-1-unknown	MKPLVV...	1		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P30085-159-unknown	TKPIID...	159	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17564
P30085-159-unknown	TKPIID...	159	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt142948

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...TYLQST	158	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17564
...TYLQST	158	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126158
...FDKEG	196	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...FDKEG	196	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt74462

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1A_HUMAN	158	LQST.\|.TKPI	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)