P30154: Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform

General Information

Protein names	- Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform - PP2A subunit A isoform PR65-beta - PP2A subunit A isoform R1-beta
Gene names	PPP2R1B
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P30154

5 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform - Isoform 3 of Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform - Isoform 4 of Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform - Isoform 5 of Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform

Sequence View

        10         20         30         40         50         60
MAGASELGTG PGAAGGDGDD SLYPIAVLID ELRNEDVQLR LNSIKKLSTI ALALGVERTR
        70         80         90        100        110        120
SELLPFLTDT IYDEDEVLLA LAEQLGNFTG LVGGPDFAHC LLPPLENLAT VEETVVRDKA
       130        140        150        160        170        180
VESLRQISQE HTPVALEAYF VPLVKRLASG DWFTSRTSAC GLFSVCYPRA SNAVKAEIRQ
       190        200        210        220        230        240
QFRSLCSDDT PMVRRAAASK LGEFAKVLEL DSVKSEIVPL FTSLASDEQD SVRLLAVEAC
       250        260        270        280        290        300
VSIAQLLSQD DLETLVMPTL RQAAEDKSWR VRYMVADRFS ELQKAMGPKI TLNDLIPAFQ
       310        320        330        340        350        360
NLLKDCEAEV RAAAAHKVKE LGENLPIEDR ETIIMNQILP YIKELVSDTN QHVKSALASV
       370        380        390        400        410        420
IMGLSTILGK ENTIEHLLPL FLAQLKDECP DVRLNIISNL DCVNEVIGIR QLSQSLLPAI
       430        440        450        460        470        480
VELAEDAKWR VRLAIIEYMP LLAGQLGVEF FDEKLNSLCM AWLVDHVYAI REAATNNLMK
       490        500        510        520        530        540
LVQKFGTEWA QNTIVPKVLV MANDPNYLHR MTTLFCINAL SEACGQEITT KQMLPIVLKM
       550        560        570        580        590        600
AGDQVANVRF NVAKSLQKIG PILDTNALQG EVKPVLQKLG QDEDMDVKYF AQEAISVLAL

A         10         20         30         40         50         60
MAGASELGTG PGAAGGDGDD SLYPIAVLID ELRNEDVQLR LNSIKKLSTI ALALGVERTR
        70         80         90        100        110        120
SELLPFLTDT IYDEDEVLLA LAEQLGNFTG LVGGPDFAHC LLPPLENLAT VEETVVRDKA
       130        140        150        160        170        180
VESLRQISQE HTPVALEAYF VPLVKRLASG DWFTSRTSAC GLFSVCYPRA SNAVKAEIRQ
       190        200        210        220        230        240
QFRSLCSDDT PMVRRAAASK LGEFAKVLEL DSVKSEIVPL FTSLASDEQD SVRLLAVEAC
       250        260        270        280        290        300
VSIAQLLSQD DLETLVMPTL RQAAEDKSWR VRYMVADRFS ELQKAMGPKI TLNDLIPAFQ
       310        320        330        340        350        360
NLLKDCEAEV RAAAAHKVKE LGENLPIEDR ETIIMNQILP YIKELVSDTN QHVKSALASV
       370        380        390        400        410        420
IMGLSTILGK ENTIEHLLPL FLAQLKDECP DVRLNIISNL DCVNEVIGIR QLSQSLLPAI
       430        440        450        460        470        480
VELAEDAKWR VRLAIIEYMP LLAGQLGVEF FDEKLNSLCM AWLVDHVYAI REAATNNLMK
       490        500        510        520        530        540
LVQKFGTEWA QNTIVPKVLV MANDPNYLHR MTTLFCINAL SEACGQEITT KQMLPIVLKM
       550        560        570        580        590        600
AGDQVANVRF NVAKSLQKIG PILDTNALQG EVKPVLQKLG QDEDMDVKYF AQEAISVLAL

A         10         20         30         40         50         60
MAGASELGTG PGAAGGDGDD SLYPIAVLID ELRNEDVQLR LNSIKKLSTI ALALGVERTR
        70         80         90        100        110        120
SELLPFLTDT IYDEDEVLLA LAEQLGNFTG LVGGPDFAHC LLPPLENLAT VEETVVRDKA
       130        140        150        160        170        180
VESLRQISQE HTPVALEAYF VPLVKRLASG DWFTSRTSAC GLFSVCYPRA SNAVKAEIRQ
       190        200        210        220        230        240
QFRSLCSDDT PMVRRAAASK LGEFAKVLEL DSVKSEIVPL FTSLASDEQD SVRLLAVEAC
       250        260        270        280        290        300
VSIAQLLSQD DLETLVMPTL RQAAEDKSWR VRYMVADRFS ELQKAMGPKI TLNDLIPAFQ
       310        320        330        340        350        360
NLLKDCEAEV RAAAAHKVKE LGENLPIEDR ETIIMNQILP YIKELVSDTN QHVKSALASV
       370        380        390        400        410        420
IMGLSTILGK ENTIEHLLPL FLAQLKDECP DVRLNIISNL DCVNEVIGIR QLSQSLLPAI
       430        440        450        460        470        480
VELAEDAKWR VRLAIIEYMP LLAGQLGVEF FDEKLNSLCM AWLVDHVYAI REAATNNLMK
       490        500        510        520        530        540
LVQKFGTEWA QNTIVPKVLV MANDPNYLHR MTTLFCINAL SEACGQEITT KQMLPIVLKM
       550        560        570        580        590        600
AGDQVANVRF NVAKSLQKIG PILDTNALQG EVKPVLQKLG QDEDMDVKYF AQEAISVLAL

A         10         20         30         40         50         60
MAGASELGTG PGAAGGDGDD SLYPIAVLID ELRNEDVQLR LNSIKKLSTI ALALGVERTR
        70         80         90        100        110        120
SELLPFLTDT IYDEDEVLLA LAEQLGNFTG LVGGPDFAHC LLPPLENLAT VEETVVRDKA
       130        140        150        160        170        180
VESLRQISQE HTPVALEAYF VPLVKRLASG DWFTSRTSAC GLFSVCYPRA SNAVKAEIRQ
       190        200        210        220        230        240
QFRSLCSDDT PMVRRAAASK LGEFAKVLEL DSVKSEIVPL FTSLASDEQD SVRLLAVEAC
       250        260        270        280        290        300
VSIAQLLSQD DLETLVMPTL RQAAEDKSWR VRYMVADRFS ELQKAMGPKI TLNDLIPAFQ
       310        320        330        340        350        360
NLLKDCEAEV RAAAAHKVKE LGENLPIEDR ETIIMNQILP YIKELVSDTN QHVKSALASV
       370        380        390        400        410        420
IMGLSTILGK ENTIEHLLPL FLAQLKDECP DVRLNIISNL DCVNEVIGIR QLSQSLLPAI
       430        440        450        460        470        480
VELAEDAKWR VRLAIIEYMP LLAGQLGVEF FDEKLNSLCM AWLVDHVYAI REAATNNLMK
       490        500        510        520        530        540
LVQKFGTEWA QNTIVPKVLV MANDPNYLHR MTTLFCINAL SEACGQEITT KQMLPIVLKM
       550        560        570        580        590        600
AGDQVANVRF NVAKSLQKIG PILDTNALQG EVKPVLQKLG QDEDMDVKYF AQEAISVLAL

A

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Directness:

Physiological Relevance:

Evidence Codes:

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Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

5 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P30154-2-unknown	MAGASE...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P30154-1-unknown	MAGASE...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt65741
P30154-1-unknown	MAGASE...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt65742
P30154-1-unknown	MAGASE...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt65743
P30154-1-unknown	MAGASE...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt65744
P30154-2-Acetylation	AGASEL...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P30154-2-Acetylation	AGASEL...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P30154-2-Acetylation	AGASEL...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P30154-2-Acetylation	AGASEL...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110706
P30154-2-Acetylation	AGASEL...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110707
P30154-2-Acetylation	AGASEL...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110708
P30154-2-Acetylation	AGASEL...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110709
P30154-14-acetylation	AGGDGD...	14	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
P30154-14-acetylation	AGGDGD...	14	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt163263
P30154-14-acetylation	AGGDGD...	14	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt163264
P30154-14-acetylation	AGGDGD...	14	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt163265
P30154-14-acetylation	AGGDGD...	14	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt163266
P30154-559-unknown	IGPILD...	559		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14075
P30154-559-unknown	IGPILD...	559		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt152512
P30154-559-unknown	IGPILD...	559		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt153370
P30154-559-unknown	IGPILD...	559		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt153590
P30154-559-unknown	IGPILD...	559		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt154106

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...KSLQKI	558	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14075
...KSLQKI	558	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135923
...KSLQKI	558	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136794
...KSLQKI	558	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt137013
...KSLQKI	558	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt137525
...VLALA	601	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...VLALA	601	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt61362
...VLALA	601	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt61361

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAM_HUMAN	558	LQKI.\|.IGPI	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)