P30305: M-phase inducer phosphatase 2

General Information

Protein names	- M-phase inducer phosphatase 2 - 3.1.3.48 - Dual specificity phosphatase Cdc25B
Gene names	CDC25B
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P30305

3 N-termini

1 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 1 of M-phase inducer phosphatase 2 - Isoform 2 of M-phase inducer phosphatase 2 - Isoform 4 of M-phase inducer phosphatase 2

Sequence View

        10         20         30         40         50         60
MEVPQPEPAP GSALSPAGVC GGAQRPGHLP GLLLGSHGLL GSPVRAAASS PVTTLTQTMH
        70         80         90        100        110        120
DLAGLGSETP KSQVGTLLFR SRSRLTHLSL SRRASESSLS SESSESSDAG LCMDSPSPMD
       130        140        150        160        170        180
PHMAEQTFEQ AIQAASRIIR NEQFAIRRFQ SMPVRLLGHS PVLRNITNSQ APDGRRKSEA
       190        200        210        220        230        240
GSGAASSSGE DKENDGFVFK MPWKPTHPSS THALAEWASR REAFAQRPSS APDLMCLSPD
       250        260        270        280        290        300
RKMEVEELSP LALGRFSLTP AEGDTEEDDG FVDILESDLK DDDAVPPGME SLISAPLVKT
       310        320        330        340        350        360
LEKEEEKDLV MYSKCQRLFR SPSMPCSVIR PILKRLERPQ DRDTPVQNKR RRSVTPPEEQ
       370        380        390        400        410        420
QEAEEPKARV LRSKSLCHDE IENLLDSDHR ELIGDYSKAF LLQTVDGKHQ DLKYISPETM
       430        440        450        460        470        480
VALLTGKFSN IVDKFVIVDC RYPYEYEGGH IKTAVNLPLE RDAESFLLKS PIAPCSLDKR
       490        500        510        520        530        540
VILIFHCEFS SERGPRMCRF IRERDRAVND YPSLYYPEMY ILKGGYKEFF PQHPNFCEPQ
       550        560        570        580
DYRPMNHEAF KDELKTFRLK TRSWAGERSR RELCSRLQDQ         10         20         30         40         50         60
MEVPQPEPAP GSALSPAGVC GGAQRPGHLP GLLLGSHGLL GSPVRAAASS PVTTLTQTMH
        70         80         90        100        110        120
DLAGLGSETP KSQVGTLLFR SRSRLTHLSL SRRASESSLS SESSESSDAG LCMDSPSPMD
       130        140        150        160        170        180
PHMAEQTFEQ AIQAASRIIR NEQFAIRRFQ SMPVRLLGHS PVLRNITNSQ APDGRRKSEA
       190        200        210        220        230        240
GSGAASSSGE DKENDGFVFK MPWKPTHPSS THALAEWASR REAFAQRPSS APDLMCLSPD
       250        260        270        280        290        300
RKMEVEELSP LALGRFSLTP AEGDTEEDDG FVDILESDLK DDDAVPPGME SLISAPLVKT
       310        320        330        340        350        360
LEKEEEKDLV MYSKCQRLFR SPSMPCSVIR PILKRLERPQ DRDTPVQNKR RRSVTPPEEQ
       370        380        390        400        410        420
QEAEEPKARV LRSKSLCHDE IENLLDSDHR ELIGDYSKAF LLQTVDGKHQ DLKYISPETM
       430        440        450        460        470        480
VALLTGKFSN IVDKFVIVDC RYPYEYEGGH IKTAVNLPLE RDAESFLLKS PIAPCSLDKR
       490        500        510        520        530        540
VILIFHCEFS SERGPRMCRF IRERDRAVND YPSLYYPEMY ILKGGYKEFF PQHPNFCEPQ
       550        560        570        580
DYRPMNHEAF KDELKTFRLK TRSWAGERSR RELCSRLQDQ         10         20         30         40         50         60
MEVPQPEPAP GSALSPAGVC GGAQRPGHLP GLLLGSHGLL GSPVRAAASS PVTTLTQTMH
        70         80         90        100        110        120
DLAGLGSETP KSQVGTLLFR SRSRLTHLSL SRRASESSLS SESSESSDAG LCMDSPSPMD
       130        140        150        160        170        180
PHMAEQTFEQ AIQAASRIIR NEQFAIRRFQ SMPVRLLGHS PVLRNITNSQ APDGRRKSEA
       190        200        210        220        230        240
GSGAASSSGE DKENDGFVFK MPWKPTHPSS THALAEWASR REAFAQRPSS APDLMCLSPD
       250        260        270        280        290        300
RKMEVEELSP LALGRFSLTP AEGDTEEDDG FVDILESDLK DDDAVPPGME SLISAPLVKT
       310        320        330        340        350        360
LEKEEEKDLV MYSKCQRLFR SPSMPCSVIR PILKRLERPQ DRDTPVQNKR RRSVTPPEEQ
       370        380        390        400        410        420
QEAEEPKARV LRSKSLCHDE IENLLDSDHR ELIGDYSKAF LLQTVDGKHQ DLKYISPETM
       430        440        450        460        470        480
VALLTGKFSN IVDKFVIVDC RYPYEYEGGH IKTAVNLPLE RDAESFLLKS PIAPCSLDKR
       490        500        510        520        530        540
VILIFHCEFS SERGPRMCRF IRERDRAVND YPSLYYPEMY ILKGGYKEFF PQHPNFCEPQ
       550        560        570        580
DYRPMNHEAF KDELKTFRLK TRSWAGERSR RELCSRLQDQ

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

3 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P30305-1-unknown	MEVPQP...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P30305-1-unknown	MEVPQP...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt81455
P30305-1-unknown	MEVPQP...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt81456
P30305-1-unknown	MEVPQP...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt81457
P30305-353-unknown	SVTPPE...	353	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt177101
P30305-353-unknown	SVTPPE...	353	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt177102
P30305-353-unknown	SVTPPE...	353	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt177100
P30305-353-	SVTPPE...	353		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...RLQDQ	580	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...RLQDQ	580	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt77074
...RLQDQ	580	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt77073
...RLQDQ	580	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt77075

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)