P30566: Adenylosuccinate lyase {ECO:0000303|PubMed:8404037}

General Information

Protein names	- Adenylosuccinate lyase {ECO:0000303\|PubMed:8404037} - ADSL {ECO:0000303\|PubMed:8404037} - ASL - 4.3.2.2 {ECO:0000269\|PubMed:16973378, ECO:0000269\|PubMed:22812634} - Adenylosuccinase {ECO:0000303\|PubMed:9266401} - ASase
Gene names	ADSL
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P30566

5 N-termini

1 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAAGGDHGSP DSYRSPLASR YASPEMCFVF SDRYKFRTWR QLWLWLAEAE QTLGLPITDE
        70         80         90        100        110        120
QIQEMKSNLE NIDFKMAAEE EKRLRHDVMA HVHTFGHCCP KAAGIIHLGA TSCYVGDNTD
       130        140        150        160        170        180
LIILRNALDL LLPKLARVIS RLADFAKERA SLPTLGFTHF QPAQLTTVGK RCCLWIQDLC
       190        200        210        220        230        240
MDLQNLKRVR DDLRFRGVKG TTGTQASFLQ LFEGDDHKVE QLDKMVTEKA GFKRAFIITG
       250        260        270        280        290        300
QTYTRKVDIE VLSVLASLGA SVHKICTDIR LLANLKEMEE PFEKQQIGSS AMPYKRNPMR
       310        320        330        340        350        360
SERCCSLARH LMTLVMDPLQ TASVQWFERT LDDSANRRIC LAEAFLTADT ILNTLQNISE
       370        380        390        400        410        420
GLVVYPKVIE RRIRQELPFM ATENIIMAMV KAGGSRQDCH EKIRVLSQQA ASVVKQEGGD
       430        440        450        460        470        480
NDLIERIQVD AYFSPIHSQL DHLLDPSSFT GRASQQVQRF LEEEVYPLLK PYESVMKVKA

ELCL

Isoforms

- Isoform 2 of Adenylosuccinate lyase

Sequence View

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Physiological Relevance:

Evidence Codes:

Methodology:

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Biological System:

Protease Assignment Confidence:

Evidence Names:

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Lab:

Protein Neighborhood

Domains & Features

5 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P30566-2-unknown	MAAGGD...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P30566-1-unknown	MAAGGD...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt86674
P30566-2-Acetylation	AAGGDH...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P30566-2-Acetylation	AAGGDH...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P30566-2-Acetylation	AAGGDH...	2	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P30566-2-Acetylation	AAGGDH...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110432
P30566-3-acetylation	AGGDHG...	3	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P30566-3-acetylation	AGGDHG...	3	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt182629
P30566-405-acetylation	VLSQQA...	405	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...AELCL	484	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
	...AELCL	484	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt82292

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)