P30876: DNA-directed RNA polymerase II subunit RPB2

General Information

Protein names	- DNA-directed RNA polymerase II subunit RPB2 - 2.7.7.6 - DNA-directed RNA polymerase II 140 kDa polypeptide - DNA-directed RNA polymerase II subunit B - RNA polymerase II subunit 2 - RNA polymerase II subunit B2
Gene names	POLR2B
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P30876

4 N-termini

2 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MYDADEDMQY DEDDDEITPD LWQEACWIVI SSYFDEKGLV RQQLDSFDEF IQMSVQRIVE
        70         80         90        100        110        120
DAPPIDLQAE AQHASGEVEE PPRYLLKFEQ IYLSKPTHWE RDGAPSPMMP NEARLRNLTY
       130        140        150        160        170        180
SAPLYVDITK TVIKEGEEQL QTQHQKTFIG KIPIMLRSTY CLLNGLTDRD LCELNECPLD
       190        200        210        220        230        240
PGGYFIINGS EKVLIAQEKM ATNTVYVFAK KDSKYAYTGE CRSCLENSSR PTSTIWVSML
       250        260        270        280        290        300
ARGGQGAKKS AIGQRIVATL PYIKQEVPII IVFRALGFVS DRDILEHIIY DFEDPEMMEM
       310        320        330        340        350        360
VKPSLDEAFV IQEQNVALNF IGSRGAKPGV TKEKRIKYAK EVLQKEMLPH VGVSDFCETK
       370        380        390        400        410        420
KAYFLGYMVH RLLLAALGRR ELDDRDHYGN KRLDLAGPLL AFLFRGMFKN LLKEVRIYAQ
       430        440        450        460        470        480
KFIDRGKDFN LELAIKTRII SDGLKYSLAT GNWGDQKKAH QARAGVSQVL NRLTFASTLS
       490        500        510        520        530        540
HLRRLNSPIG RDGKLAKPRQ LHNTLWGMVC PAETPEGHAV GLVKNLALMA YISVGSQPSP
       550        560        570        580        590        600
ILEFLEEWSM ENLEEISPAA IADATKIFVN GCWVGIHKDP EQLMNTLRKL RRQMDIIVSE
       610        620        630        640        650        660
VSMIRDIRER EIRIYTDAGR ICRPLLIVEK QKLLLKKRHI DQLKEREYNN YSWQDLVASG
       670        680        690        700        710        720
VVEYIDTLEE ETVMLAMTPD DLQEKEVAYC STYTHCEIHP SMILGVCASI IPFPDHNQSP
       730        740        750        760        770        780
RNTYQSAMGK QAMGVYITNF HVRMDTLAHV LYYPQKPLVT TRSMEYLRFR ELPAGINSIV
       790        800        810        820        830        840
AIASYTGYNQ EDSVIMNRSA VDRGFFRSVF YRSYKEQESK KGFDQEEVFE KPTRETCQGM
       850        860        870        880        890        900
RHAIYDKLDD DGLIAPGVRV SGDDVIIGKT VTLPENEDEL ESTNRRYTKR DCSTFLRTSE
       910        920        930        940        950        960
TGIVDQVMVT LNQEGYKFCK IRVRSVRIPQ IGDKFASRHG QKGTCGIQYR QEDMPFTCEG
       970        980        990       1000       1010       1020
ITPDIIINPH AIPSRMTIGH LIECLQGKVS ANKGEIGDAT PFNDAVNVQK ISNLLSDYGY
      1030       1040       1050       1060       1070       1080
HLRGNEVLYN GFTGRKITSQ IFIGPTYYQR LKHMVDDKIH SRARGPIQIL NRQPMEGRSR
      1090       1100       1110       1120       1130       1140
DGGLRFGEME RDCQIAHGAA QFLRERLFEA SDPYQVHVCN LCGIMAIANT RTHTYECRGC
      1150       1160       1170
RNKTQISLVR MPYACKLLFQ ELMSMSIAPR MMSV

Isoforms

Sequence View

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(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

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Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 2 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P30876-1-unknown	MYDADE...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P30876-8-unknown	MQYDED...	8	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000391452
P30876-8-unknown	MQYDED...	8	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000407728
P30876-784-	SYTGYN...	784		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P30876-870-	TVTLPE...	870		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...EDAPPI	64	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000408638
	...RMMSV	1174	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)