P31695: Neurogenic locus notch homolog protein 4 {ECO:0000250|UniProtKB:Q99466}
| Protein names | - Neurogenic locus notch homolog protein 4 {ECO:0000250|UniProtKB:Q99466} - Notch 4 - Transforming protein Int-3 - Notch 4 extracellular truncation - Notch 4 intracellular domain |
|---|---|
| Gene names | Notch4 |
| Organism | Mus musculus |
| Protease Family | |
| Protease ID | |
| Chromosome location | |
| UniProt ID | P31695 |
4
N-termini
2
C-termini
1
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MQPQLLLLLL LPLNFPVILT RELLCGGSPE PCANGGTCLR LSRGQGICQC APGFLGETCQ
70 80 90 100 110 120
FPDPCRDTQL CKNGGSCQAL LPTPPSSRSP TSPLTPHFSC TCPSGFTGDR CQTHLEELCP
130 140 150 160 170 180
PSFCSNGGHC YVQASGRPQC SCEPGWTGEQ CQLRDFCSAN PCANGGVCLA TYPQIQCRCP
190 200 210 220 230 240
PGFEGHTCER DINECFLEPG PCPQGTSCHN TLGSYQCLCP VGQEGPQCKL RKGACPPGSC
250 260 270 280 290 300
LNGGTCQLVP EGHSTFHLCL CPPGFTGLDC EMNPDDCVRH QCQNGATCLD GLDTYTCLCP
310 320 330 340 350 360
KTWKGWDCSE DIDECEARGP PRCRNGGTCQ NTAGSFHCVC VSGWGGAGCE ENLDDCAAAT
370 380 390 400 410 420
CAPGSTCIDR VGSFSCLCPP GRTGLLCHLE DMCLSQPCHV NAQCSTNPLT GSTLCICQPG
430 440 450 460 470 480
YSGSTCHQDL DECQMAQQGP SPCEHGGSCI NTPGSFNCLC LPGYTGSRCE ADHNECLSQP
490 500 510 520 530 540
CHPGSTCLDL LATFHCLCPP GLEGRLCEVE VNECTSNPCL NQAACHDLLN GFQCLCLPGF
550 560 570 580 590 600
TGARCEKDMD ECSSTPCANG GRCRDQPGAF YCECLPGFEG PHCEKEVDEC LSDPCPVGAS
610 620 630 640 650 660
CLDLPGAFFC LCRPGFTGQL CEVPLCTPNM CQPGQQCQGQ EHRAPCLCPD GSPGCVPAED
670 680 690 700 710 720
NCPCHHGHCQ RSLCVCDEGW TGPECETELG GCISTPCAHG GTCHPQPSGY NCTCPAGYMG
730 740 750 760 770 780
LTCSEEVTAC HSGPCLNGGS CSIRPEGYSC TCLPSHTGRH CQTAVDHCVS ASCLNGGTCV
790 800 810 820 830 840
NKPGTFFCLC ATGFQGLHCE EKTNPSCADS PCRNKATCQD TPRGARCLCS PGYTGSSCQT
850 860 870 880 890 900
LIDLCARKPC PHTARCLQSG PSFQCLCLQG WTGALCDFPL SCQKAAMSQG IEISGLCQNG
910 920 930 940 950 960
GLCIDTGSSY FCRCPPGFQG KLCQDNVNPC EPNPCHHGST CVPQPSGYVC QCAPGYEGQN
970 980 990 1000 1010 1020
CSKVLDACQS QPCHNHGTCT SRPGGFHCAC PPGFVGLRCE GDVDECLDRP CHPSGTAACH
1030 1040 1050 1060 1070 1080
SLANAFYCQC LPGHTGQRCE VEMDLCQSQP CSNGGSCEIT TGPPPGFTCH CPKGFEGPTC
1090 1100 1110 1120 1130 1140
SHKALSCGIH HCHNGGLCLP SPKPGSPPLC ACLSGFGGPD CLTPPAPPGC GPPSPCLHNG
1150 1160 1170 1180 1190 1200
TCTETPGLGN PGFQCTCPPD SPGPRCQRPG ASGCEGRGGD GTCDAGCSGP GGDWDGGDCS
1210 1220 1230 1240 1250 1260
LGVPDPWKGC PPHSQCWLLF RDGRCHPQCD SEECLFDGYD CEIPLTCIPA YDQYCRDHFH
1270 1280 1290 1300 1310 1320
NGHCEKGCNN AECGWDGGDC RPEGEDSEGR PSLALLVVLR PPALDQQLLA LARVLSLTLR
1330 1340 1350 1360 1370 1380
VGLWVRKDSE GRNMVFPYPG TRAKEELSGA RDSSSWERQA PPTQPLGKET ESLGAGFVVV
1390 1400 1410 1420 1430 1440
MGVDLSRCGP EHPASRCPWD SGLLLRFLAA MAAVGALEPL LPGPLLAAHP QAGTRPSANQ
1450 1460 1470 1480 1490 1500
LPWPILCSPV VGVLLLALGA LLVLQLIRRR RREHGALWLP PGFIRRPQTQ QAPHRRRPPL
1510 1520 1530 1540 1550 1560
GEDNIGLKAL KPEAEVDEDG VAMCSGPEEG EAEETASASR CQLWPLNSGC GELPQAAMLT
1570 1580 1590 1600 1610 1620
PPQECESEVL DVDTCGPDGV TPLMSAVFCG GVQSTTGASP QRLGLGNLEP WEPLLDRGAC
1630 1640 1650 1660 1670 1680
PQAHTVGTGE TPLHLAARFS RPTAARRLLE AGANPNQPDR AGRTPLHTAV AADAREVCQL
1690 1700 1710 1720 1730 1740
LLASRQTTVD ARTEDGTTPL MLAARLAVED LVEELIAARA DVGARDKRGK TALHWAAAVN
1750 1760 1770 1780 1790 1800
NARAARSLLQ AGADKDAQDS REQTPLFLAA REGAVEVAQL LLELGAARGL RDQAGLAPGD
1810 1820 1830 1840 1850 1860
VARQRSHWDL LTLLEGAGPT TQEARAHART TPGGGAAPRC RTLSAGARPR GGGACLQART
1870 1880 1890 1900 1910 1920
WSVDLGARGG KVYARCRSRS GSCGGPTTRG RRFSAGSRGR RGARASQDDW PRDWVALEAC
1930 1940 1950 1960
GSACSAPIPP PSLTPSPERG SPQVAWGLPV HQEIPLNSVV RNLN
Isoforms
Sequence View
Protein Neighborhood
Domains & Features
4 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates
N-termini
| Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
|---|---|---|---|---|---|---|---|---|---|
| P31695-21-unknown | RELLCG... | 21 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| P31695-1411-unknown | MAAVGA... | 1411 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| P31695-1428-unknown | AHPQAG... | 1428 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| P31695-1463-unknown | VLQLIR... | 1463 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC34788 | |||
| P31695-1463-unknown | VLQLIR... | 1463 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot |
C-termini
| Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| ...LGALLV | 1462 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC34788 | |||
| ...VRNLN | 1964 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot |
Cleavages
| Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| PSN1_MOUSE | 1462 | ALLV.|.VLQL | inferred from experiment | unknown | MEROPS | Kopan R | Saxena MT et al.:Murine notch homologs (N1-4) un... (A22.001) | 11518718, |
Substrates
| Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|