TopFIND 4.0

P49769: Presenilin-1

General Information

Protein names
- Presenilin-1
- PS-1
- 3.4.23.-
- Protein S182
- Presenilin-1 NTF subunit
- Presenilin-1 CTF subunit
- Presenilin-1 CTF12
- PS1-CTF12
Gene names Psen1
Organism Mus musculus
Protease Family A22.001
Protease ID A22.001
Chromosome location
UniProt ID P49769

3

N-termini

2

C-termini

0

Cleavages

9

Substrates

Sequence

        10         20         30         40         50         60 
MTEIPAPLSY FQNAQMSEDS HSSSAIRSQN DSQERQQQHD RQRLDNPEPI SNGRPQSNSR 
        70         80         90        100        110        120 
QVVEQDEEED EELTLKYGAK HVIMLFVPVT LCMVVVVATI KSVSFYTRKD GQLIYTPFTE 
       130        140        150        160        170        180 
DTETVGQRAL HSILNAAIMI SVIVIMTILL VVLYKYRCYK VIHAWLIISS LLLLFFFSFI 
       190        200        210        220        230        240 
YLGEVFKTYN VAVDYVTVAL LIWNFGVVGM IAIHWKGPLR LQQAYLIMIS ALMALVFIKY 
       250        260        270        280        290        300 
LPEWTAWLIL AVISVYDLVA VLCPKGPLRM LVETAQERNE TLFPALIYSS TMVWLVNMAE 
       310        320        330        340        350        360 
GDPEAQRRVP KNPKYNTQRA ERETQDSGSG NDDGGFSEEW EAQRDSHLGP HRSTPESRAA 
       370        380        390        400        410        420 
VQELSGSILT SEDPEERGVK LGLGDFIFYS VLVGKASATA SGDWNTTIAC FVAILIGLCL 
       430        440        450        460    
TLLLLAIFKK ALPALPISIT FGLVFYFATD YLVQPFMDQL AFHQFYI

Isoforms

- Isoform 2 of Presenilin-1

Sequence View

        10         20         30         40         50         60 
MTEIPAPLSY FQNAQMSEDS HSSSAIRSQN DSQERQQQHD RQRLDNPEPI SNGRPQSNSR 
        70         80         90        100        110        120 
QVVEQDEEED EELTLKYGAK HVIMLFVPVT LCMVVVVATI KSVSFYTRKD GQLIYTPFTE 
       130        140        150        160        170        180 
DTETVGQRAL HSILNAAIMI SVIVIMTILL VVLYKYRCYK VIHAWLIISS LLLLFFFSFI 
       190        200        210        220        230        240 
YLGEVFKTYN VAVDYVTVAL LIWNFGVVGM IAIHWKGPLR LQQAYLIMIS ALMALVFIKY 
       250        260        270        280        290        300 
LPEWTAWLIL AVISVYDLVA VLCPKGPLRM LVETAQERNE TLFPALIYSS TMVWLVNMAE 
       310        320        330        340        350        360 
GDPEAQRRVP KNPKYNTQRA ERETQDSGSG NDDGGFSEEW EAQRDSHLGP HRSTPESRAA 
       370        380        390        400        410        420 
VQELSGSILT SEDPEERGVK LGLGDFIFYS VLVGKASATA SGDWNTTIAC FVAILIGLCL 
       430        440        450        460    
TLLLLAIFKK ALPALPISIT FGLVFYFATD YLVQPFMDQL AFHQFYI



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Protein Neighborhood

Domains & Features

3 N-termini - 2 C-termini - 0 Cleavages - 9 Substrates

N-termini

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...WLVNMA 298 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    ...HQFYI 467 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates