P31749: RAC-alpha serine/threonine-protein kinase

General Information

Protein names	- RAC-alpha serine/threonine-protein kinase - 2.7.11.1 - Protein kinase B - PKB - Protein kinase B alpha - PKB alpha - Proto-oncogene c-Akt - RAC-PK-alpha
Gene names	AKT1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P31749

8 N-termini

6 C-termini

3 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSDVAIVKEG WLHKRGEYIK TWRPRYFLLK NDGTFIGYKE RPQDVDQREA PLNNFSVAQC
        70         80         90        100        110        120
QLMKTERPRP NTFIIRCLQW TTVIERTFHV ETPEEREEWT TAIQTVADGL KKQEEEEMDF
       130        140        150        160        170        180
RSGSPSDNSG AEEMEVSLAK PKHRVTMNEF EYLKLLGKGT FGKVILVKEK ATGRYYAMKI
       190        200        210        220        230        240
LKKEVIVAKD EVAHTLTENR VLQNSRHPFL TALKYSFQTH DRLCFVMEYA NGGELFFHLS
       250        260        270        280        290        300
RERVFSEDRA RFYGAEIVSA LDYLHSEKNV VYRDLKLENL MLDKDGHIKI TDFGLCKEGI
       310        320        330        340        350        360
KDGATMKTFC GTPEYLAPEV LEDNDYGRAV DWWGLGVVMY EMMCGRLPFY NQDHEKLFEL
       370        380        390        400        410        420
ILMEEIRFPR TLGPEAKSLL SGLLKKDPKQ RLGGGSEDAK EIMQHRFFAG IVWQHVYEKK
       430        440        450        460        470        480
LSPPFKPQVT SETDTRYFDE EFTAQMITIT PPDQDDSMEC VDSERRPHFP QFSYSASGTA

Isoforms

- Isoform 2 of RAC-alpha serine/threonine-protein kinase

Sequence View

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Protein Neighborhood

Domains & Features

8 N-termini - 6 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P31749-1-unknown	MSDVAI...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P31749-63-unknown	MKTERP...	63	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000443897
P31749-63-unknown	MKTERP...	63	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000451290
P31749-109-unknown	GLKKQE...	109	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1780
P31749-109-	GLKKQE...	109		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P31749-120-unknown	FRSGSP...	120	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1781
P31749-281-unknown	MLDKDG...	281	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000450681
P31749-306-unknown	MKTFCG...	306	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000451470
P31749-463-unknown	SERRPH...	463	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1782

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...TFHVET	91	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000451824
...QTVADG	108	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1780
...EEEMDF	119	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1781
...KVILVK	167	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000451290
...MECVDS	462	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1782
...ASGTA	480	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP3_HUMAN	108	VADG.\|.GLKK	inferred from experiment	unknown	MEROPS	Mercurio AM	Bachelder RE et al.:The cleavage of Akt/protein kin... (C14.003)	11463786,
CASP3_HUMAN	119	EMDF.\|.FRSG	inferred from experiment	unknown	MEROPS	Mercurio AM	Bachelder RE et al.:The cleavage of Akt/protein kin... (C14.003)	11463786,
CASP3_HUMAN	462	CVDS.\|.SERR	inferred from experiment	unknown	MEROPS	Songyang Z	Xu J et al.:The role of Asp-462 in regulati... (C14.003)	12124386,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)