P35499: Sodium channel protein type 4 subunit alpha
Protein names | - Sodium channel protein type 4 subunit alpha - SkM1 {ECO:0000303|PubMed:1315496} - Sodium channel protein skeletal muscle subunit alpha - Sodium channel protein type IV subunit alpha - Voltage-gated sodium channel subunit alpha Nav1.4 |
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Gene names | SCN4A |
Organism | Homo sapiens |
Protease Family | |
Protease ID | |
Chromosome location | |
UniProt ID | P35499 |
3
N-termini
3
C-termini
2
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MARPSLCTLV PLGPECLRPF TRESLAAIEQ RAVEEEARLQ RNKQMEIEEP ERKPRSDLEA
70 80 90 100 110 120
GKNLPMIYGD PPPEVIGIPL EDLDPYYSNK KTFIVLNKGK AIFRFSATPA LYLLSPFSVV
130 140 150 160 170 180
RRGAIKVLIH ALFSMFIMIT ILTNCVFMTM SDPPPWSKNV EYTFTGIYTF ESLIKILARG
190 200 210 220 230 240
FCVDDFTFLR DPWNWLDFSV IMMAYLTEFV DLGNISALRT FRVLRALKTI TVIPGLKTIV
250 260 270 280 290 300
GALIQSVKKL SDVMILTVFC LSVFALVGLQ LFMGNLRQKC VRWPPPFNDT NTTWYSNDTW
310 320 330 340 350 360
YGNDTWYGNE MWYGNDSWYA NDTWNSHASW ATNDTFDWDA YISDEGNFYF LEGSNDALLC
370 380 390 400 410 420
GNSSDAGHCP EGYECIKTGR NPNYGYTSYD TFSWAFLALF RLMTQDYWEN LFQLTLRAAG
430 440 450 460 470 480
KTYMIFFVVI IFLGSFYLIN LILAVVAMAY AEQNEATLAE DKEKEEEFQQ MLEKFKKHQE
490 500 510 520 530 540
ELEKAKAAQA LEGGEADGDP AHGKDCNGSL DTSQGEKGAP RQSSSGDSGI SDAMEELEEA
550 560 570 580 590 600
HQKCPPWWYK CAHKVLIWNC CAPWLKFKNI IHLIVMDPFV DLGITICIVL NTLFMAMEHY
610 620 630 640 650 660
PMTEHFDNVL TVGNLVFTGI FTAEMVLKLI AMDPYEYFQQ GWNIFDSIIV TLSLVELGLA
670 680 690 700 710 720
NVQGLSVLRS FRLLRVFKLA KSWPTLNMLI KIIGNSVGAL GNLTLVLAII VFIFAVVGMQ
730 740 750 760 770 780
LFGKSYKECV CKIALDCNLP RWHMHDFFHS FLIVFRILCG EWIETMWDCM EVAGQAMCLT
790 800 810 820 830 840
VFLMVMVIGN LVVLNLFLAL LLSSFSADSL AASDEDGEMN NLQIAIGRIK LGIGFAKAFL
850 860 870 880 890 900
LGLLHGKILS PKDIMLSLGE ADGAGEAGEA GETAPEDEKK EPPEEDLKKD NHILNHMGLA
910 920 930 940 950 960
DGPPSSLELD HLNFINNPYL TIQVPIASEE SDLEMPTEEE TDTFSEPEDS KKPPQPLYDG
970 980 990 1000 1010 1020
NSSVCSTADY KPPEEDPEEQ AEENPEGEQP EECFTEACVQ RWPCLYVDIS QGRGKKWWTL
1030 1040 1050 1060 1070 1080
RRACFKIVEH NWFETFIVFM ILLSSGALAF EDIYIEQRRV IRTILEYADK VFTYIFIMEM
1090 1100 1110 1120 1130 1140
LLKWVAYGFK VYFTNAWCWL DFLIVDVSII SLVANWLGYS ELGPIKSLRT LRALRPLRAL
1150 1160 1170 1180 1190 1200
SRFEGMRVVV NALLGAIPSI MNVLLVCLIF WLIFSIMGVN LFAGKFYYCI NTTTSERFDI
1210 1220 1230 1240 1250 1260
SEVNNKSECE SLMHTGQVRW LNVKVNYDNV GLGYLSLLQV ATFKGWMDIM YAAVDSREKE
1270 1280 1290 1300 1310 1320
EQPQYEVNLY MYLYFVIFII FGSFFTLNLF IGVIIDNFNQ QKKKLGGKDI FMTEEQKKYY
1330 1340 1350 1360 1370 1380
NAMKKLGSKK PQKPIPRPQN KIQGMVYDLV TKQAFDITIM ILICLNMVTM MVETDNQSQL
1390 1400 1410 1420 1430 1440
KVDILYNINM IFIIIFTGEC VLKMLALRQY YFTVGWNIFD FVVVILSIVG LALSDLIQKY
1450 1460 1470 1480 1490 1500
FVSPTLFRVI RLARIGRVLR LIRGAKGIRT LLFALMMSLP ALFNIGLLLF LVMFIYSIFG
1510 1520 1530 1540 1550 1560
MSNFAYVKKE SGIDDMFNFE TFGNSIICLF EITTSAGWDG LLNPILNSGP PDCDPNLENP
1570 1580 1590 1600 1610 1620
GTSVKGDCGN PSIGICFFCS YIIISFLIVV NMYIAIILEN FNVATEESSE PLGEDDFEMF
1630 1640 1650 1660 1670 1680
YETWEKFDPD ATQFIAYSRL SDFVDTLQEP LRIAKPNKIK LITLDLPMVP GDKIHCLDIL
1690 1700 1710 1720 1730 1740
FALTKEVLGD SGEMDALKQT MEEKFMAANP SKVSYEPITT TLKRKHEEVC AIKIQRAYRR
1750 1760 1770 1780 1790 1800
HLLQRSMKQA SYMYRHSHDG SGDDAPEKEG LLANTMSKMY GHENGNSSSP SPEEKGEAGD
1810 1820 1830
AGPTMGLMPI SPSDTAWPPA PPPGQTVRPG VKESLV
Isoforms
Sequence View
Protein Neighborhood
Domains & Features
3 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
P35499-1-unknown | MARPSL... | 1 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
P35499-290-unknown | TNTTWY... | 290 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC11458 | |||
P35499-335-unknown | TFDWDA... | 335 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC11459 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...PPFNDT | 289 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC11458 | |||
...WATNDT | 334 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC11459 | |||
...KESLV | 1836 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot |
Cleavages
Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
GRAB_HUMAN | 289 | FNDT.|.TNTT | inferred from experiment | unknown | MEROPS | Rogers SW | Gahring L et al.:Granzyme B proteolysis of a neu... (S01.010) | 11160179, |
GRAB_HUMAN | 334 | TNDT.|.TFDW | inferred from experiment | unknown | MEROPS | Rogers SW | Gahring L et al.:Granzyme B proteolysis of a neu... (S01.010) | 11160179, |
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
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