P36544: Neuronal acetylcholine receptor subunit alpha-7

General Information

Protein names	- Neuronal acetylcholine receptor subunit alpha-7
Gene names	CHRNA7
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P36544

3 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Neuronal acetylcholine receptor subunit alpha-7 - Isoform 3 of Neuronal acetylcholine receptor subunit alpha-7 - Isoform 3 of Neuronal acetylcholine receptor subunit alpha-7

Sequence View

        10         20         30         40         50         60
MRCSPGGVWL ALAASLLHVS LQGEFQRKLY KELVKNYNPL ERPVANDSQP LTVYFSLSLL
        70         80         90        100        110        120
QIMDVDEKNQ VLTTNIWLQM SWTDHYLQWN VSEYPGVKTV RFPDGQIWKP DILLYNSADE
       130        140        150        160        170        180
RFDATFHTNV LVNSSGHCQY LPPGIFKSSC YIDVRWFPFD VQHCKLKFGS WSYGGWSLDL
       190        200        210        220        230        240
QMQEADISGY IPNGEWDLVG IPGKRSERFY ECCKEPYPDV TFTVTMRRRT LYYGLNLLIP
       250        260        270        280        290        300
CVLISALALL VFLLPADSGE KISLGITVLL SLTVFMLLVA EIMPATSDSV PLIAQYFAST
       310        320        330        340        350        360
MIIVGLSVVV TVIVLQYHHH DPDGGKMPKW TRVILLNWCA WFLRMKRPGE DKVRPACQHK
       370        380        390        400        410        420
QRRCSLASVE MSAVAPPPAS NGNLLYIGFR GLDGVHCVPT PDSGVVCGRM ACSPTHDEHL
       430        440        450        460        470        480
LHGGQPPEGD PDLAKILEEV RYIANRFRCQ DESEAVCSEW KFAACVVDRL CLMAFSVFTI
       490        500
ICTIGILMSA PNFVEAVSKD FA         10         20         30         40         50         60
MRCSPGGVWL ALAASLLHVS LQGEFQRKLY KELVKNYNPL ERPVANDSQP LTVYFSLSLL
        70         80         90        100        110        120
QIMDVDEKNQ VLTTNIWLQM SWTDHYLQWN VSEYPGVKTV RFPDGQIWKP DILLYNSADE
       130        140        150        160        170        180
RFDATFHTNV LVNSSGHCQY LPPGIFKSSC YIDVRWFPFD VQHCKLKFGS WSYGGWSLDL
       190        200        210        220        230        240
QMQEADISGY IPNGEWDLVG IPGKRSERFY ECCKEPYPDV TFTVTMRRRT LYYGLNLLIP
       250        260        270        280        290        300
CVLISALALL VFLLPADSGE KISLGITVLL SLTVFMLLVA EIMPATSDSV PLIAQYFAST
       310        320        330        340        350        360
MIIVGLSVVV TVIVLQYHHH DPDGGKMPKW TRVILLNWCA WFLRMKRPGE DKVRPACQHK
       370        380        390        400        410        420
QRRCSLASVE MSAVAPPPAS NGNLLYIGFR GLDGVHCVPT PDSGVVCGRM ACSPTHDEHL
       430        440        450        460        470        480
LHGGQPPEGD PDLAKILEEV RYIANRFRCQ DESEAVCSEW KFAACVVDRL CLMAFSVFTI
       490        500
ICTIGILMSA PNFVEAVSKD FA         10         20         30         40         50         60
MRCSPGGVWL ALAASLLHVS LQGEFQRKLY KELVKNYNPL ERPVANDSQP LTVYFSLSLL
        70         80         90        100        110        120
QIMDVDEKNQ VLTTNIWLQM SWTDHYLQWN VSEYPGVKTV RFPDGQIWKP DILLYNSADE
       130        140        150        160        170        180
RFDATFHTNV LVNSSGHCQY LPPGIFKSSC YIDVRWFPFD VQHCKLKFGS WSYGGWSLDL
       190        200        210        220        230        240
QMQEADISGY IPNGEWDLVG IPGKRSERFY ECCKEPYPDV TFTVTMRRRT LYYGLNLLIP
       250        260        270        280        290        300
CVLISALALL VFLLPADSGE KISLGITVLL SLTVFMLLVA EIMPATSDSV PLIAQYFAST
       310        320        330        340        350        360
MIIVGLSVVV TVIVLQYHHH DPDGGKMPKW TRVILLNWCA WFLRMKRPGE DKVRPACQHK
       370        380        390        400        410        420
QRRCSLASVE MSAVAPPPAS NGNLLYIGFR GLDGVHCVPT PDSGVVCGRM ACSPTHDEHL
       430        440        450        460        470        480
LHGGQPPEGD PDLAKILEEV RYIANRFRCQ DESEAVCSEW KFAACVVDRL CLMAFSVFTI
       490        500
ICTIGILMSA PNFVEAVSKD FA

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

3 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P36544-23-unknown	GEFQRK...	23	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P36544-23-unknown	GEFQRK...	23	inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)
P36544-23-unknown	GEFQRK...	23	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt113235
P36544-48-unknown	SQPLTV...	48	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11473
P36544-48-unknown	SQPLTV...	48	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt141137
P36544-182-unknown	MQEADI...	182	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt66151
P36544-182-unknown	MQEADI...	182	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt101718

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...PVANDS	47	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11473
...PVANDS	47	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt124293
...SKDFA	502	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...SKDFA	502	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt61769
...SKDFA	502	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt61768

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	47	ANDS.\|.SQPL	inferred from experiment	unknown	MEROPS	Rogers SW	Gahring L et al.:Granzyme B proteolysis of a neu... (S01.010)	11160179,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)