P36969: Phospholipid hydroperoxide glutathione peroxidase

General Information

Protein names	- Phospholipid hydroperoxide glutathione peroxidase - PHGPx - 1.11.1.12 - Glutathione peroxidase 4 {ECO:0000303\|PubMed:9705830} - GPx-4 {ECO:0000303\|PubMed:9705830} - GSHPx-4 {ECO:0000303\|PubMed:9705830}
Gene names	GPX4
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P36969

4 N-termini

2 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform Cytoplasmic of Phospholipid hydroperoxide glutathione peroxidase, mitochondrial - Isoform Cytoplasmic of Phospholipid hydroperoxide glutathione peroxidase

Sequence View

        10         20         30         40         50         60
MSLGRLCRLL KPALLCGALA APGLAGTMCA SRDDWRCARS MHEFSAKDID GHMVNLDKYR
        70         80         90        100        110        120
GFVCIVTNVA SQUGKTEVNY TQLVDLHARY AECGLRILAF PCNQFGKQEP GSNEEIKEFA
       130        140        150        160        170        180
AGYNVKFDMF SKICVNGDDA HPLWKWMKIQ PKGKGILGNA IKWNFTKFLI DKNGCVVKRY
       190
GPMEEPLVIE KDLPHYF         10         20         30         40         50         60
MSLGRLCRLL KPALLCGALA APGLAGTMCA SRDDWRCARS MHEFSAKDID GHMVNLDKYR
        70         80         90        100        110        120
GFVCIVTNVA SQUGKTEVNY TQLVDLHARY AECGLRILAF PCNQFGKQEP GSNEEIKEFA
       130        140        150        160        170        180
AGYNVKFDMF SKICVNGDDA HPLWKWMKIQ PKGKGILGNA IKWNFTKFLI DKNGCVVKRY
       190
GPMEEPLVIE KDLPHYF

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Evidence Codes:

Methodology:

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Protease Assignment Confidence:

Evidence Names:

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Protein Neighborhood

Domains & Features

4 N-termini - 2 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P36969-0-unknown	FMSLGR...	0	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P36969-28-unknown	MCASRD...	28	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt76380
P36969-74-	GKTEVN...	74		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P36969-74-unknown	GKTEVN...	74	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt171890

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...LPHYF	197	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...LPHYF	197	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt71998
...LPHYF	197		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...LPHYF	197		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...LPHYF	197		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...LPHYF	197		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)