P38936: Cyclin-dependent kinase inhibitor 1

General Information

Protein names	- Cyclin-dependent kinase inhibitor 1 - CDK-interacting protein 1 - Melanoma differentiation-associated protein 6 - MDA-6 - p21
Gene names	CDKN1A
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P38936

6 N-termini

5 C-termini

4 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSEPAGDVRQ NPCGSKACRR LFGPVDSEQL SRDCDALMAG CIQEARERWN FDFVTETPLE
        70         80         90        100        110        120
GDFAWERVRG LGLPKLYLPT GPRRGRDELG GGRRPGTSPA LLQGTAEEDH VDLSLSCTLV
       130        140        150        160
PRSGEQAEGS PGGPGDSQGR KRRQTSMTDF YHSKRRLIFS KRKP

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

6 N-termini - 5 C-termini - 4 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P38936-2-unknown	MSEPAG...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P38936-2-Acetylation	SEPAGD...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P38936-2-Acetylation	SEPAGD...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P38936-2-Acetylation	SEPAGD...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P38936-63-unknown	FAWERV...	63		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11482
P38936-81-unknown	GPRRGR...	81		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC27791
P38936-113-unknown	LSLSCT...	113		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1817
P38936-150-unknown	FYHSKR...	150		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1818

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...PLEGDF	62	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11482
...LYLPTG	80	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27791
...EDHVDL	112	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1817
...TSMTDF	149	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1818
...SKRKP	164	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	62	EGDF.\|.FAWE	inferred from experiment	unknown	MEROPS	Preston GA	Pendergraft WF 3rd et al.:Proteinase 3 sidesteps caspases... (S01.010)	14675038,
PRTN3_HUMAN	80	LPTG.\|.GPRR	inferred from experiment	unknown	MEROPS	Preston GA	Pendergraft WF 3rd et al.:Proteinase 3 sidesteps caspases... (S01.010)	14675038,
CASP3_HUMAN	112	HVDL.\|.LSLS	inferred from experiment	unknown	MEROPS	Lee SK	Park JA et al.:Caspase 3 specifically cleaves ... (C14.003)	9799125,
CASP3_HUMAN	149	MTDF.\|.FYHS	inferred from experiment	unknown	MEROPS	Lee SK	Park JA et al.:Caspase 3 specifically cleaves ... (C14.003)	9799125,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)