P40306: Proteasome subunit beta type-10

General Information

Protein names	- Proteasome subunit beta type-10 - 3.4.25.1 - Low molecular mass protein 10 - Macropain subunit MECl-1 - Multicatalytic endopeptidase complex subunit MECl-1 - Proteasome MECl-1 - Proteasome subunit beta-2i
Gene names	PSMB10
Organism	Homo sapiens
Protease Family
Protease ID	T01.014
Chromosome location
UniProt ID	P40306

6 N-termini

1 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MLKPALEPRG GFSFENCQRN ASLERVLPGL KVPHARKTGT TIAGLVFQDG VILGADTRAT
        70         80         90        100        110        120
NDSVVADKSC EKIHFIAPKI YCCGAGVAAD AEMTTRMVAS KMELHALSTG REPRVATVTR
       130        140        150        160        170        180
ILRQTLFRYQ GHVGASLIVG GVDLTGPQLY GVHPHGSYSR LPFTALGSGQ DAALAVLEDR
       190        200        210        220        230        240
FQPNMTLEAA QGLLVEAVTA GILGDLGSGG NVDACVITKT GAKLLRTLSS PTEPVKRSGR
       250        260        270
YHFVPGTTAV LTQTVKPLTL ELVEETVQAM EVE

Isoforms

Sequence View

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(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

6 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P40306-1-acetylation	MLKPAL...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P40306-1-acetylation	MLKPAL...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P40306-1-	MLKPAL...	1			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P40306-1-	MLKPAL...	1			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P40306-40-	TTIAGL...	40			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P40306-40-unknown	TTIAGL...	40		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P40306-40-unknown	TTIAGL...	40		inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
P40306-50-	GVILGA...	50			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P40306-121-unknown	ILRQTL...	121		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000463811

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...AMEVE	273	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)