P40939: Trifunctional enzyme subunit alpha, mitochondrial

General Information

Protein names	- Trifunctional enzyme subunit alpha, mitochondrial - 78 kDa gastrin-binding protein - Monolysocardiolipin acyltransferase {ECO:0000305\|PubMed:23152787} - 2.3.1.- {ECO:0000269\|PubMed:23152787} - TP-alpha - Long-chain enoyl-CoA hydratase - 4.2.1.17 {ECO:0000269\|PubMed:1550553, ECO:0000269\|PubMed:8135828, ECO:0000269\|PubMed:8163672, ECO:0000269\|PubMed:8651282} - Long chain 3-hydroxyacyl-CoA dehydrogenase - 1.1.1.211 {ECO:0000269\|PubMed:1550553, ECO:0000269\|PubMed:8135828, ECO:0000269\|PubMed:8163672, ECO:0000269\|PubMed:8651282}
Gene names	HADHA
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P40939

4 N-termini

4 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MVACRAIGIL SRFSAFRILR SRGYICRNFT GSSALLTRTH INYGVKGDVA VVRINSPNSK
        70         80         90        100        110        120
VNTLSKELHS EFSEVMNEIW ASDQIRSAVL ISSKPGCFIA GADINMLAAC KTLQEVTQLS
       130        140        150        160        170        180
QEAQRIVEKL EKSTKPIVAA INGSCLGGGL EVAISCQYRI ATKDRKTVLG TPEVLLGALP
       190        200        210        220        230        240
GAGGTQRLPK MVGVPAALDM MLTGRSIRAD RAKKMGLVDQ LVEPLGPGLK PPEERTIEYL
       250        260        270        280        290        300
EEVAITFAKG LADKKISPKR DKGLVEKLTA YAMTIPFVRQ QVYKKVEEKV RKQTKGLYPA
       310        320        330        340        350        360
PLKIIDVVKT GIEQGSDAGY LCESQKFGEL VMTKESKALM GLYHGQVLCK KNKFGAPQKD
       370        380        390        400        410        420
VKHLAILGAG LMGAGIAQVS VDKGLKTILK DATLTALDRG QQQVFKGLND KVKKKALTSF
       430        440        450        460        470        480
ERDSIFSNLT GQLDYQGFEK ADMVIEAVFE DLSLKHRVLK EVEAVIPDHC IFASNTSALP
       490        500        510        520        530        540
ISEIAAVSKR PEKVIGMHYF SPVDKMQLLE IITTEKTSKD TSASAVAVGL KQGKVIIVVK
       550        560        570        580        590        600
DGPGFYTTRC LAPMMSEVIR ILQEGVDPKK LDSLTTSFGF PVGAATLVDE VGVDVAKHVA
       610        620        630        640        650        660
EDLGKVFGER FGGGNPELLT QMVSKGFLGR KSGKGFYIYQ EGVKRKDLNS DMDSILASLK
       670        680        690        700        710        720
LPPKSEVSSD EDIQFRLVTR FVNEAVMCLQ EGILATPAEG DIGAVFGLGF PPCLGGPFRF
       730        740        750        760
VDLYGAQKIV DRLKKYEAAY GKQFTPCQLL ADHANSPNKK FYQ

Isoforms

- Isoform 2 of Trifunctional enzyme subunit alpha, mitochondrial - Isoform 2 of Trifunctional enzyme subunit alpha, mitochondrial

Sequence View

        10         20         30         40         50         60
MVACRAIGIL SRFSAFRILR SRGYICRNFT GSSALLTRTH INYGVKGDVA VVRINSPNSK
        70         80         90        100        110        120
VNTLSKELHS EFSEVMNEIW ASDQIRSAVL ISSKPGCFIA GADINMLAAC KTLQEVTQLS
       130        140        150        160        170        180
QEAQRIVEKL EKSTKPIVAA INGSCLGGGL EVAISCQYRI ATKDRKTVLG TPEVLLGALP
       190        200        210        220        230        240
GAGGTQRLPK MVGVPAALDM MLTGRSIRAD RAKKMGLVDQ LVEPLGPGLK PPEERTIEYL
       250        260        270        280        290        300
EEVAITFAKG LADKKISPKR DKGLVEKLTA YAMTIPFVRQ QVYKKVEEKV RKQTKGLYPA
       310        320        330        340        350        360
PLKIIDVVKT GIEQGSDAGY LCESQKFGEL VMTKESKALM GLYHGQVLCK KNKFGAPQKD
       370        380        390        400        410        420
VKHLAILGAG LMGAGIAQVS VDKGLKTILK DATLTALDRG QQQVFKGLND KVKKKALTSF
       430        440        450        460        470        480
ERDSIFSNLT GQLDYQGFEK ADMVIEAVFE DLSLKHRVLK EVEAVIPDHC IFASNTSALP
       490        500        510        520        530        540
ISEIAAVSKR PEKVIGMHYF SPVDKMQLLE IITTEKTSKD TSASAVAVGL KQGKVIIVVK
       550        560        570        580        590        600
DGPGFYTTRC LAPMMSEVIR ILQEGVDPKK LDSLTTSFGF PVGAATLVDE VGVDVAKHVA
       610        620        630        640        650        660
EDLGKVFGER FGGGNPELLT QMVSKGFLGR KSGKGFYIYQ EGVKRKDLNS DMDSILASLK
       670        680        690        700        710        720
LPPKSEVSSD EDIQFRLVTR FVNEAVMCLQ EGILATPAEG DIGAVFGLGF PPCLGGPFRF
       730        740        750        760
VDLYGAQKIV DRLKKYEAAY GKQFTPCQLL ADHANSPNKK FYQ         10         20         30         40         50         60
MVACRAIGIL SRFSAFRILR SRGYICRNFT GSSALLTRTH INYGVKGDVA VVRINSPNSK
        70         80         90        100        110        120
VNTLSKELHS EFSEVMNEIW ASDQIRSAVL ISSKPGCFIA GADINMLAAC KTLQEVTQLS
       130        140        150        160        170        180
QEAQRIVEKL EKSTKPIVAA INGSCLGGGL EVAISCQYRI ATKDRKTVLG TPEVLLGALP
       190        200        210        220        230        240
GAGGTQRLPK MVGVPAALDM MLTGRSIRAD RAKKMGLVDQ LVEPLGPGLK PPEERTIEYL
       250        260        270        280        290        300
EEVAITFAKG LADKKISPKR DKGLVEKLTA YAMTIPFVRQ QVYKKVEEKV RKQTKGLYPA
       310        320        330        340        350        360
PLKIIDVVKT GIEQGSDAGY LCESQKFGEL VMTKESKALM GLYHGQVLCK KNKFGAPQKD
       370        380        390        400        410        420
VKHLAILGAG LMGAGIAQVS VDKGLKTILK DATLTALDRG QQQVFKGLND KVKKKALTSF
       430        440        450        460        470        480
ERDSIFSNLT GQLDYQGFEK ADMVIEAVFE DLSLKHRVLK EVEAVIPDHC IFASNTSALP
       490        500        510        520        530        540
ISEIAAVSKR PEKVIGMHYF SPVDKMQLLE IITTEKTSKD TSASAVAVGL KQGKVIIVVK
       550        560        570        580        590        600
DGPGFYTTRC LAPMMSEVIR ILQEGVDPKK LDSLTTSFGF PVGAATLVDE VGVDVAKHVA
       610        620        630        640        650        660
EDLGKVFGER FGGGNPELLT QMVSKGFLGR KSGKGFYIYQ EGVKRKDLNS DMDSILASLK
       670        680        690        700        710        720
LPPKSEVSSD EDIQFRLVTR FVNEAVMCLQ EGILATPAEG DIGAVFGLGF PPCLGGPFRF
       730        740        750        760
VDLYGAQKIV DRLKKYEAAY GKQFTPCQLL ADHANSPNKK FYQ

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P40939-37-unknown	TRTHIN...	37	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P40939-469-unknown	HCIFAS...	469	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11501
P40939-515-unknown	EKTSKD...	515	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000438039
P40939-595-unknown	VAKHVA...	595	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11502

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...AVIPDH	468	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11501
...EVGVDV	594	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11502
...DRLKKY	735	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000438039
...KKFYQ	763	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	468	IPDH.\|.HCIF	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAB_HUMAN	594	GVDV.\|.VAKH	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,

TopFIND

P40939: Trifunctional enzyme subunit alpha, mitochondrial

General Information

4

N-termini

4

C-termini

2

Cleavages

0

Substrates

Sequence

Isoforms

Filter Information:

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

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Protease Assignment Confidence:

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Protein Neighborhood

Domains & Features

4 N-termini - 4 C-termini - 2 Cleavages - 0 Substrates

N-termini

C-termini

Cleavages

Substrates