P41743: Protein kinase C iota type

General Information

Protein names	- Protein kinase C iota type - 2.7.11.13 - Atypical protein kinase C-lambda/iota - PRKC-lambda/iota - aPKC-lambda/iota - nPKC-iota
Gene names	PRKCI
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P41743

4 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MPTQRDSSTM SHTVAGGGSG DHSHQVRVKA YYRGDIMITH FEPSISFEGL CNEVRDMCSF
        70         80         90        100        110        120
DNEQLFTMKW IDEEGDPCTV SSQLELEEAF RLYELNKDSE LLIHVFPCVP ERPGMPCPGE
       130        140        150        160        170        180
DKSIYRRGAR RWRKLYCANG HTFQAKRFNR RAHCAICTDR IWGLGRQGYK CINCKLLVHK
       190        200        210        220        230        240
KCHKLVTIEC GRHSLPQEPV MPMDQSSMHS DHAQTVIPYN PSSHESLDQV GEEKEAMNTR
       250        260        270        280        290        300
ESGKASSSLG LQDFDLLRVI GRGSYAKVLL VRLKKTDRIY AMKVVKKELV NDDEDIDWVQ
       310        320        330        340        350        360
TEKHVFEQAS NHPFLVGLHS CFQTESRLFF VIEYVNGGDL MFHMQRQRKL PEEHARFYSA
       370        380        390        400        410        420
EISLALNYLH ERGIIYRDLK LDNVLLDSEG HIKLTDYGMC KEGLRPGDTT STFCGTPNYI
       430        440        450        460        470        480
APEILRGEDY GFSVDWWALG VLMFEMMAGR SPFDIVGSSD NPDQNTEDYL FQVILEKQIR
       490        500        510        520        530        540
IPRSLSVKAA SVLKSFLNKD PKERLGCHPQ TGFADIQGHP FFRNVDWDMM EQKQVVPPFK
       550        560        570        580        590
PNISGEFGLD NFDSQFTNEP VQLTPDDDDI VRKIDQSEFE GFEYINPLLM SAEECV

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

4 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P41743-2-unknown	MPTQRD...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P41743-2-Acetylation	PTQRDS...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P41743-7-	SSTMSH...	7			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P41743-7-	SSTMSH...	7			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P41743-589-unknown	LMSAEE...	589		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14122

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...YINPLL	588	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14122
	...AEECV	596	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAM_HUMAN	588	NPLL.\|.LMSA	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)