P42695: Condensin-2 complex subunit D3

General Information

Protein names	- Condensin-2 complex subunit D3 - Non-SMC condensin II complex subunit D3 - hCAP-D3
Gene names	NCAPD3
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P42695

5 N-termini

6 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MVALRGLGSG LQPWCPLDLR LEWVDTVWEL DFTETEPLDP SIEAEIIETG LAAFTKLYES
        70         80         90        100        110        120
LLPFATGEHG SMESIWTFFI ENNVSHSTLV ALFYHFVQIV HKKNVSVQYR EYGLHAAGLY
       130        140        150        160        170        180
FLLLEVPGSV ANQVFHPVMF DKCIQTLKKS WPQESNLNRK RKKEQPKSSQ ANPGRHRKRG
       190        200        210        220        230        240
KPPRREDIEM DEIIEEQEDE NICFSARDLS QIRNAIFHLL KNFLRLLPKF SLKEKPQCVQ
       250        260        270        280        290        300
NCIEVFVSLT NFEPVLHECH VTQARALNQA KYIPELAYYG LYLLCSPIHG EGDKVISCVF
       310        320        330        340        350        360
HQMLSVILML EVGEGSHRAP LAVTSQVINC RNQAVQFISA LVDELKESIF PVVRILLQHI
       370        380        390        400        410        420
CAKVVDKSEY RTFAAQSLVQ LLSKLPCGEY AMFIAWLYKY SRSSKIPHRV FTLDVVLALL
       430        440        450        460        470        480
ELPEREVDNT LSLEHQKFLK HKFLVQEIMF DRCLDKAPTV RSKALSSFAH CLELTVTSAS
       490        500        510        520        530        540
ESILELLINS PTFSVIESHP GTLLRNSSAF SYQRQTSNRS EPSGEINIDS SGETVGSGER
       550        560        570        580        590        600
CVMAMLRRRI RDEKTNVRKS ALQVLVSILK HCDVSGMKED LWILQDQCRD PAVSVRKQAL
       610        620        630        640        650        660
QSLTELLMAQ PRCVQIQKAW LRGVVPVVMD CESTVQEKAL EFLDQLLLQN IRHHSHFHSG
       670        680        690        700        710        720
DDSQVLAWAL LTLLTTESQE LSRYLNKAFH IWSKKEKFSP TFINNVISHT GTEHSAPAWM
       730        740        750        760        770        780
LLSKIAGSSP RLDYSRIIQS WEKISSQQNP NSNTLGHILC VIGHIAKHLP KSTRDKVTDA
       790        800        810        820        830        840
VKCKLNGFQW SLEVISSAVD ALQRLCRASA ETPAEEQELL TQVCGDVLST CEHRLSNIVL
       850        860        870        880        890        900
KENGTGNMDE DLLVKYIFTL GDIAQLCPAR VEKRIFLLIQ SVLASSADAD HSPSSQGSSE
       910        920        930        940        950        960
APASQPPPQV RGSVMPSVIR AHAIITLGKL CLQHEDLAKK SIPALVRELE VCEDVAVRNN
       970        980        990       1000       1010       1020
VIIVMCDLCI RYTIMVDKYI PNISMCLKDS DPFIRKQTLI LLTNLLQEEF VKWKGSLFFR
      1030       1040       1050       1060       1070       1080
FVSTLIDSHP DIASFGEFCL AHLLLKRNPV MFFQHFIECI FHFNNYEKHE KYNKFPQSER
      1090       1100       1110       1120       1130       1140
EKRLFSLKGK SNKERRMKIY KFLLEHFTDE QRFNITSKIC LSILACFADG ILPLDLDASE
      1150       1160       1170       1180       1190       1200
LLSDTFEVLS SKEIKLLAMR SKPDKDLLME EDDMALANVV MQEAQKKLIS QVQKRNFIEN
      1210       1220       1230       1240       1250       1260
IIPIIISLKT VLEKNKIPAL RELMHYLREV MQDYRDELKD FFAVDKQLAS ELEYDMKKYQ
      1270       1280       1290       1300       1310       1320
EQLVQEQELA KHADVAGTAG GAEVAPVAQV ALCLETVPVP AGQENPAMSP AVSQPCTPRA
      1330       1340       1350       1360       1370       1380
SAGHVAVSSP TPETGPLQRL LPKARPMSLS TIAILNSVKK AVESKSRHRS RSLGVLPFTL
      1390       1400       1410       1420       1430       1440
NSGSPEKTCS QVSSYSLEQE SNGEIEHVTK RAISTPEKSI SDVTFGAGVS YIGTPRTPSS
      1450       1460       1470       1480       1490
AKEKIEGRSQ GNDILCLSLP DKPPPQPQQW NVRSPARNKD TPACSRRSLR KTPLKTAN

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

5 N-termini - 6 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P42695-1-unknown	MVALRG...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P42695-520-unknown	SEPSGE...	520	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10077
P42695-530-	SSGETV...	530		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P42695-965-unknown	MCDLCI...	965	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000435173
P42695-1396-unknown	SLEQES...	1396		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...DFTETE	35	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000431436
...QTSNRS	519	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10077
...MHYLRE	1228	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000435173
...APVAQV	1289	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000432532
...LKTAN	1498		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...LKTAN	1498	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...LKTAN	1498		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAA_HUMAN	519	SNRS.\|.SEPS	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)