P43004: Excitatory amino acid transporter 2

General Information

Protein names	- Excitatory amino acid transporter 2 - Glutamate/aspartate transporter II - Sodium-dependent glutamate/aspartate transporter 2 - Solute carrier family 1 member 2
Gene names	SLC1A2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P43004

4 N-termini

4 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Excitatory amino acid transporter 2 - Isoform 3 of Excitatory amino acid transporter 2

Sequence View

        10         20         30         40         50         60
MASTEGANNM PKQVEVRMHD SHLGSEEPKH RHLGLRLCDK LGKNLLLTLT VFGVILGAVC
        70         80         90        100        110        120
GGLLRLASPI HPDVVMLIAF PGDILMRMLK MLILPLIISS LITGLSGLDA KASGRLGTRA
       130        140        150        160        170        180
MVYYMSTTII AAVLGVILVL AIHPGNPKLK KQLGPGKKND EVSSLDAFLD LIRNLFPENL
       190        200        210        220        230        240
VQACFQQIQT VTKKVLVAPP PDEEANATSA VVSLLNETVT EVPEETKMVI KKGLEFKDGM
       250        260        270        280        290        300
NVLGLIGFFI AFGIAMGKMG DQAKLMVDFF NILNEIVMKL VIMIMWYSPL GIACLICGKI
       310        320        330        340        350        360
IAIKDLEVVA RQLGMYMVTV IIGLIIHGGI FLPLIYFVVT RKNPFSFFAG IFQAWITALG
       370        380        390        400        410        420
TASSAGTLPV TFRCLEENLG IDKRVTRFVL PVGATINMDG TALYEAVAAI FIAQMNGVVL
       430        440        450        460        470        480
DGGQIVTVSL TATLASVGAA SIPSAGLVTM LLILTAVGLP TEDISLLVAV DWLLDRMRTS
       490        500        510        520        530        540
VNVVGDSFGA GIVYHLSKSE LDTIDSQHRV HEDIEMTKTQ SIYDDMKNHR ESNSNQCVYA
       550        560        570
AHNSVIVDEC KVTLAANGKS ADCSVEEEPW KREK         10         20         30         40         50         60
MASTEGANNM PKQVEVRMHD SHLGSEEPKH RHLGLRLCDK LGKNLLLTLT VFGVILGAVC
        70         80         90        100        110        120
GGLLRLASPI HPDVVMLIAF PGDILMRMLK MLILPLIISS LITGLSGLDA KASGRLGTRA
       130        140        150        160        170        180
MVYYMSTTII AAVLGVILVL AIHPGNPKLK KQLGPGKKND EVSSLDAFLD LIRNLFPENL
       190        200        210        220        230        240
VQACFQQIQT VTKKVLVAPP PDEEANATSA VVSLLNETVT EVPEETKMVI KKGLEFKDGM
       250        260        270        280        290        300
NVLGLIGFFI AFGIAMGKMG DQAKLMVDFF NILNEIVMKL VIMIMWYSPL GIACLICGKI
       310        320        330        340        350        360
IAIKDLEVVA RQLGMYMVTV IIGLIIHGGI FLPLIYFVVT RKNPFSFFAG IFQAWITALG
       370        380        390        400        410        420
TASSAGTLPV TFRCLEENLG IDKRVTRFVL PVGATINMDG TALYEAVAAI FIAQMNGVVL
       430        440        450        460        470        480
DGGQIVTVSL TATLASVGAA SIPSAGLVTM LLILTAVGLP TEDISLLVAV DWLLDRMRTS
       490        500        510        520        530        540
VNVVGDSFGA GIVYHLSKSE LDTIDSQHRV HEDIEMTKTQ SIYDDMKNHR ESNSNQCVYA
       550        560        570
AHNSVIVDEC KVTLAANGKS ADCSVEEEPW KREK

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 4 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P43004-1-unknown	MASTEG...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P43004-1-unknown	MASTEG...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt73555
P43004-10-unknown	MPKQVE...	10	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt73554
P43004-10-unknown	MPKQVE...	10	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000379099
P43004-10-unknown	MPKQVE...	10	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000379102
P43004-10-unknown	MPKQVE...	10	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt100558
P43004-479-unknown	TSVNVV...	479	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000435406
P43004-479-unknown	TSVNVV...	479	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt199647
P43004-479-unknown	TSVNVV...	479	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt199646
P43004-506-unknown	SQHRVH...	506	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1833
P43004-506-unknown	SQHRVH...	506	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt153380
P43004-506-unknown	SQHRVH...	506	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt153488

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...PPPDEE	203	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000406133
...PPPDEE	203	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155666
...PPPDEE	203	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155665
...LDTIDS	505	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1833
...LDTIDS	505	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136805
...LDTIDS	505	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136911
...IYDDMK	526	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000436029
...WKREK	574	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...WKREK	574	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt69172

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP3_HUMAN	505	TIDS.\|.SQHR	inferred from experiment	unknown	MEROPS	Trotti D	Boston-Howes W et al.:Caspase-3 cleaves and inactivat... (C14.003)	16567804,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)