P43026: Growth/differentiation factor 5
| Protein names | - Growth/differentiation factor 5 - GDF-5 - Bone morphogenetic protein 14 - BMP-14 - Cartilage-derived morphogenetic protein 1 - CDMP-1 - Lipopolysaccharide-associated protein 4 - LAP-4 - LPS-associated protein 4 - Radotermin |
|---|---|
| Gene names | GDF5 |
| Organism | Homo sapiens |
| Protease Family | |
| Protease ID | |
| Chromosome location | |
| UniProt ID | P43026 |
4
N-termini
4
C-termini
3
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MRLPKLLTFL LWYLAWLDLE FICTVLGAPD LGQRPQGTRP GLAKAEAKER PPLARNVFRP
70 80 90 100 110 120
GGHSYGGGAT NANARAKGGT GQTGGLTQPK KDEPKKLPPR PGGPEPKPGH PPQTRQATAR
130 140 150 160 170 180
TVTPKGQLPG GKAPPKAGSV PSSFLLKKAR EPGPPREPKE PFRPPPITPH EYMLSLYRTL
190 200 210 220 230 240
SDADRKGGNS SVKLEAGLAN TITSFIDKGQ DDRGPVVRKQ RYVFDISALE KDGLLGAELR
250 260 270 280 290 300
ILRKKPSDTA KPAAPGGGRA AQLKLSSCPS GRQPASLLDV RSVPGLDGSG WEVFDIWKLF
310 320 330 340 350 360
RNFKNSAQLC LELEAWERGR AVDLRGLGFD RAARQVHEKA LFLVFGRTKK RDLFFNEIKA
370 380 390 400 410 420
RSGQDDKTVY EYLFSQRRKR RAPLATRQGK RPSKNLKARC SRKALHVNFK DMGWDDWIIA
430 440 450 460 470 480
PLEYEAFHCE GLCEFPLRSH LEPTNHAVIQ TLMNSMDPES TPPTCCVPTR LSPISILFID
490 500
SANNVVYKQY EDMVVESCGC R
Isoforms
Sequence View
Protein Neighborhood
Domains & Features
4 N-termini - 4 C-termini - 3 Cleavages - 0 Substrates
N-termini
| Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
|---|---|---|---|---|---|---|---|---|---|
| P43026-28-unknown | APDLGQ... | 28 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| P43026-381-unknown | RAPLAT... | 381 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC9766 | |||
| P43026-382-unknown | APLATR... | 382 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| P43026-382-unknown | APLATR... | 382 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC9767 | |||
| P43026-386-unknown | TRQGKR... | 386 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC21415 |
C-termini
| Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| ...QRRKRR | 380 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC9766 | |||
| ...RRKRRA | 381 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC9767 | |||
| ...RAPLAT | 385 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC21415 | |||
| ...SCGCR | 501 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot |
Cleavages
| Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| FURIN_HUMAN | 380 | RKRR.|.RAPL | inferred from experiment | unknown | MEROPS | Mundlos S | Ploger F et al.:Brachydactyly type A2 associate... (S08.071) | 18203755, |
| FURIN_HUMAN | 381 | KRRA.|.APLA | inferred from experiment | unknown | MEROPS | Mundlos S | Ploger F et al.:Brachydactyly type A2 associate... (S08.071) | 18203755, |
| MMP13_HUMAN | 385 | PLAT.|.TRQG | inferred from experiment | unknown | MEROPS | Mundlos S | Ploger F et al.:Brachydactyly type A2 associate... (S08.071) | 18203755, |
Substrates
| Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|