P43250: G protein-coupled receptor kinase 6

General Information

Protein names	- G protein-coupled receptor kinase 6 - 2.7.11.16 - G protein-coupled receptor kinase GRK6
Gene names	GRK6
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P43250

4 N-termini

1 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform GRK6B of G protein-coupled receptor kinase 6 - Isoform GRK6C of G protein-coupled receptor kinase 6

Sequence View

        10         20         30         40         50         60
MELENIVANT VLLKAREGGG GNRKGKSKKW RQMLQFPHIS QCEELRLSLE RDYHSLCERQ
        70         80         90        100        110        120
PIGRLLFREF CATRPELSRC VAFLDGVAEY EVTPDDKRKA CGRQLTQNFL SHTGPDLIPE
       130        140        150        160        170        180
VPRQLVTNCT QRLEQGPCKD LFQELTRLTH EYLSVAPFAD YLDSIYFNRF LQWKWLERQP
       190        200        210        220        230        240
VTKNTFRQYR VLGKGGFGEV CACQVRATGK MYACKKLEKK RIKKRKGEAM ALNEKQILEK
       250        260        270        280        290        300
VNSRFVVSLA YAYETKDALC LVLTLMNGGD LKFHIYHMGQ AGFPEARAVF YAAEICCGLE
       310        320        330        340        350        360
DLHRERIVYR DLKPENILLD DHGHIRISDL GLAVHVPEGQ TIKGRVGTVG YMAPEVVKNE
       370        380        390        400        410        420
RYTFSPDWWA LGCLLYEMIA GQSPFQQRKK KIKREEVERL VKEVPEEYSE RFSPQARSLC
       430        440        450        460        470        480
SQLLCKDPAE RLGCRGGSAR EVKEHPLFKK LNFKRLGAGM LEPPFKPDPQ AIYCKDVLDI
       490        500        510        520        530        540
EQFSTVKGVE LEPTDQDFYQ KFATGSVPIP WQNEMVETEC FQELNVFGLD GSVPPDLDWK
       550        560        570
GQPPAPPKKG LLQRLFSRQD CCGNCSDSEE ELPTRL         10         20         30         40         50         60
MELENIVANT VLLKAREGGG GNRKGKSKKW RQMLQFPHIS QCEELRLSLE RDYHSLCERQ
        70         80         90        100        110        120
PIGRLLFREF CATRPELSRC VAFLDGVAEY EVTPDDKRKA CGRQLTQNFL SHTGPDLIPE
       130        140        150        160        170        180
VPRQLVTNCT QRLEQGPCKD LFQELTRLTH EYLSVAPFAD YLDSIYFNRF LQWKWLERQP
       190        200        210        220        230        240
VTKNTFRQYR VLGKGGFGEV CACQVRATGK MYACKKLEKK RIKKRKGEAM ALNEKQILEK
       250        260        270        280        290        300
VNSRFVVSLA YAYETKDALC LVLTLMNGGD LKFHIYHMGQ AGFPEARAVF YAAEICCGLE
       310        320        330        340        350        360
DLHRERIVYR DLKPENILLD DHGHIRISDL GLAVHVPEGQ TIKGRVGTVG YMAPEVVKNE
       370        380        390        400        410        420
RYTFSPDWWA LGCLLYEMIA GQSPFQQRKK KIKREEVERL VKEVPEEYSE RFSPQARSLC
       430        440        450        460        470        480
SQLLCKDPAE RLGCRGGSAR EVKEHPLFKK LNFKRLGAGM LEPPFKPDPQ AIYCKDVLDI
       490        500        510        520        530        540
EQFSTVKGVE LEPTDQDFYQ KFATGSVPIP WQNEMVETEC FQELNVFGLD GSVPPDLDWK
       550        560        570
GQPPAPPKKG LLQRLFSRQD CCGNCSDSEE ELPTRL

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P43250-1-unknown	MELENI...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P43250-1-unknown	MELENI...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt76465
P43250-1-unknown	MELENI...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt76466
P43250-1-acetylation	MELENI...	1	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
P43250-1-acetylation	MELENI...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt163274
P43250-1-acetylation	MELENI...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt163275
P43250-86-unknown	GVAEYE...	86		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt176090
P43250-86-unknown	GVAEYE...	86		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt176091
P43250-86-	GVAEYE...	86			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P43250-86-	GVAEYE...	86			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...LPTRL	576	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)