P43403: Tyrosine-protein kinase ZAP-70

General Information

Protein names	- Tyrosine-protein kinase ZAP-70 - 2.7.10.2 - 70 kDa zeta-chain associated protein - Syk-related tyrosine kinase
Gene names	ZAP70
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P43403

6 N-termini

1 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Tyrosine-protein kinase ZAP-70 - Isoform 3 of Tyrosine-protein kinase ZAP-70

Sequence View

        10         20         30         40         50         60
MPDPAAHLPF FYGSISRAEA EEHLKLAGMA DGLFLLRQCL RSLGGYVLSL VHDVRFHHFP
        70         80         90        100        110        120
IERQLNGTYA IAGGKAHCGP AELCEFYSRD PDGLPCNLRK PCNRPSGLEP QPGVFDCLRD
       130        140        150        160        170        180
AMVRDYVRQT WKLEGEALEQ AIISQAPQVE KLIATTAHER MPWYHSSLTR EEAERKLYSG
       190        200        210        220        230        240
AQTDGKFLLR PRKEQGTYAL SLIYGKTVYH YLISQDKAGK YCIPEGTKFD TLWQLVEYLK
       250        260        270        280        290        300
LKADGLIYCL KEACPNSSAS NASGAAAPTL PAHPSTLTHP QRRIDTLNSD GYTPEPARIT
       310        320        330        340        350        360
SPDKPRPMPM DTSVYESPYS DPEELKDKKL FLKRDNLLIA DIELGCGNFG SVRQGVYRMR
       370        380        390        400        410        420
KKQIDVAIKV LKQGTEKADT EEMMREAQIM HQLDNPYIVR LIGVCQAEAL MLVMEMAGGG
       430        440        450        460        470        480
PLHKFLVGKR EEIPVSNVAE LLHQVSMGMK YLEEKNFVHR DLAARNVLLV NRHYAKISDF
       490        500        510        520        530        540
GLSKALGADD SYYTARSAGK WPLKWYAPEC INFRKFSSRS DVWSYGVTMW EALSYGQKPY
       550        560        570        580        590        600
KKMKGPEVMA FIEQGKRMEC PPECPPELYA LMSDCWIYKW EDRPDFLTVE QRMRACYYSL
       610
ASKVEGPPGS TQKAEAACA         10         20         30         40         50         60
MPDPAAHLPF FYGSISRAEA EEHLKLAGMA DGLFLLRQCL RSLGGYVLSL VHDVRFHHFP
        70         80         90        100        110        120
IERQLNGTYA IAGGKAHCGP AELCEFYSRD PDGLPCNLRK PCNRPSGLEP QPGVFDCLRD
       130        140        150        160        170        180
AMVRDYVRQT WKLEGEALEQ AIISQAPQVE KLIATTAHER MPWYHSSLTR EEAERKLYSG
       190        200        210        220        230        240
AQTDGKFLLR PRKEQGTYAL SLIYGKTVYH YLISQDKAGK YCIPEGTKFD TLWQLVEYLK
       250        260        270        280        290        300
LKADGLIYCL KEACPNSSAS NASGAAAPTL PAHPSTLTHP QRRIDTLNSD GYTPEPARIT
       310        320        330        340        350        360
SPDKPRPMPM DTSVYESPYS DPEELKDKKL FLKRDNLLIA DIELGCGNFG SVRQGVYRMR
       370        380        390        400        410        420
KKQIDVAIKV LKQGTEKADT EEMMREAQIM HQLDNPYIVR LIGVCQAEAL MLVMEMAGGG
       430        440        450        460        470        480
PLHKFLVGKR EEIPVSNVAE LLHQVSMGMK YLEEKNFVHR DLAARNVLLV NRHYAKISDF
       490        500        510        520        530        540
GLSKALGADD SYYTARSAGK WPLKWYAPEC INFRKFSSRS DVWSYGVTMW EALSYGQKPY
       550        560        570        580        590        600
KKMKGPEVMA FIEQGKRMEC PPECPPELYA LMSDCWIYKW EDRPDFLTVE QRMRACYYSL
       610
ASKVEGPPGS TQKAEAACA

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

6 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P43403-1-unknown	MPDPAA...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P43403-262-unknown	ASGAAA...	262	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt172786
P43403-262-	ASGAAA...	262		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P43403-291-unknown	GYTPEP...	291	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt171754
P43403-291-	GYTPEP...	291		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P43403-308-unknown	MPMDTS...	308	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt94944
P43403-308-unknown	MPMDTS...	308	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt108384

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...EAACA	619	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...EAACA	619	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt90562
...EAACA	619	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt90563

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)