TopFIND 4.0

P43681: Neuronal acetylcholine receptor subunit alpha-4

General Information

Protein names
- Neuronal acetylcholine receptor subunit alpha-4
Gene names CHRNA4
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID P43681

2

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MELGGPGAPR LLPPLLLLLG TGLLRASSHV ETRAHAEERL LKKLFSGYNK WSRPVANISD 
        70         80         90        100        110        120 
VVLVRFGLSI AQLIDVDEKN QMMTTNVWVK QEWHDYKLRW DPADYENVTS IRIPSELIWR 
       130        140        150        160        170        180 
PDIVLYNNAD GDFAVTHLTK AHLFHDGRVQ WTPPAIYKSS CSIDVTFFPF DQQNCTMKFG 
       190        200        210        220        230        240 
SWTYDKAKID LVNMHSRVDQ LDFWESGEWV IVDAVGTYNT RKYECCAEIY PDITYAFVIR 
       250        260        270        280        290        300 
RLPLFYTINL IIPCLLISCL TVLVFYLPSE CGEKITLCIS VLLSLTVFLL LITEIIPSTS 
       310        320        330        340        350        360 
LVIPLIGEYL LFTMIFVTLS IVITVFVLNV HHRSPRTHTM PTWVRRVFLD IVPRLLLMKR 
       370        380        390        400        410        420 
PSVVKDNCRR LIESMHKMAS APRFWPEPEG EPPATSGTQS LHPPSPSFCV PLDVPAEPGP 
       430        440        450        460        470        480 
SCKSPSDQLP PQQPLEAEKA SPHPSPGPCR PPHGTQAPGL AKARSLSVQH MSSPGEAVEG 
       490        500        510        520        530        540 
GVRCRSRSIQ YCVPRDDAAP EADGQAAGAL ASRNTHSAEL PPPDQPSPCK CTCKKEPSSV 
       550        560        570        580        590        600 
SPSATVKTRS TKAPPPHLPL SPALTRAVEG VQYIADHLKA EDTDFSVKED WKYVAMVIDR 
       610        620    
IFLWMFIIVC LLGTVGLFLP PWLAGMI

Isoforms

- Isoform 2 of Neuronal acetylcholine receptor subunit alpha-4

Sequence View

        10         20         30         40         50         60 
MELGGPGAPR LLPPLLLLLG TGLLRASSHV ETRAHAEERL LKKLFSGYNK WSRPVANISD 
        70         80         90        100        110        120 
VVLVRFGLSI AQLIDVDEKN QMMTTNVWVK QEWHDYKLRW DPADYENVTS IRIPSELIWR 
       130        140        150        160        170        180 
PDIVLYNNAD GDFAVTHLTK AHLFHDGRVQ WTPPAIYKSS CSIDVTFFPF DQQNCTMKFG 
       190        200        210        220        230        240 
SWTYDKAKID LVNMHSRVDQ LDFWESGEWV IVDAVGTYNT RKYECCAEIY PDITYAFVIR 
       250        260        270        280        290        300 
RLPLFYTINL IIPCLLISCL TVLVFYLPSE CGEKITLCIS VLLSLTVFLL LITEIIPSTS 
       310        320        330        340        350        360 
LVIPLIGEYL LFTMIFVTLS IVITVFVLNV HHRSPRTHTM PTWVRRVFLD IVPRLLLMKR 
       370        380        390        400        410        420 
PSVVKDNCRR LIESMHKMAS APRFWPEPEG EPPATSGTQS LHPPSPSFCV PLDVPAEPGP 
       430        440        450        460        470        480 
SCKSPSDQLP PQQPLEAEKA SPHPSPGPCR PPHGTQAPGL AKARSLSVQH MSSPGEAVEG 
       490        500        510        520        530        540 
GVRCRSRSIQ YCVPRDDAAP EADGQAAGAL ASRNTHSAEL PPPDQPSPCK CTCKKEPSSV 
       550        560        570        580        590        600 
SPSATVKTRS TKAPPPHLPL SPALTRAVEG VQYIADHLKA EDTDFSVKED WKYVAMVIDR 
       610        620    
IFLWMFIIVC LLGTVGLFLP PWLAGMI



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Evidence Codes:


Methodology:


Perturbation of System:


Biological System:


Protease Assignment Confidence:


Evidence Names:


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Lab:



Protein Neighborhood

Domains & Features

2 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    P43681-29-unknown HVETRA... 29 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    P43681-361-acetylation PSVVKD... 361 acetylation- N-TAILS Overall Laboratory Lange_Huesgen_et_al-RBC
    P43681-361-acetylation PSVVKD... 361 acetylation- inferred from isoform by sequence similarity unknown TopFIND inferred from TNt182718

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...LAGMI 627 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    ...LAGMI 627 inferred from isoform by sequence similarity unknown TopFIND inferred from TCt61765

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)